Role of the gluten-free diet on neurological-EEG findings and sleep disordered breathing in children with celiac disease

Parisi, Pasquale; Pietropaoli, Nicoletta; Ferretti, Alessandro; Nenna, Raffaella; Mastrogiorgio, Gerarda; Pozzo, Marco; Principessa, Luigi; Bonamico, Margherita; Villa, Maria Pia

doi:10.1016/j.seizure.2014.09.016

Cited by 38 publications

(55 citation statements)

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“…This broader view of the disease seen as an inflammatory disease is supported by clinical observations of extra-intestinal manifestations such as dermatological, hepatic, osteological, endocrine and neurological signs (57) . The most severe neurological symptoms are dementia, amnesia, ataxia, acalculia, epilepsy, chronic neuropathies, confusion, personality changes (58) , cognitive deficits (59) , multifocal encephalopathy, neuromyelitis optica, muscular hypotonia, delayed motor development (60) and headaches (61,62) , some of which could improve with GFD treatment (61,63) . Due to high levels of antigliadin antibodies, CD is seen as the common cause of neurological syndromes, particularly cerebellar ataxia, whose origin remains unknown.…”

Section: Neurological Complications and Cognitive Impairment In Coelimentioning

confidence: 99%

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The progression of coeliac disease: its neurological and psychiatric implications

et al. 2016

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The aim of the paper is to show the various neurological and psychiatric symptoms in coeliac disease (CD). CD is a T cell-mediated, tissuespecific autoimmune disease which affects genetically susceptible individuals after dietary exposure to proline-and glutamine-rich proteins contained in certain cereal grains. Genetics, environmental factors and different immune systems, together with the presence of auto-antigens, are taken into account when identifying the pathogenesis of CD. CD pathogenesis is related to immune dysregulation, which involves the gastrointestinal system, and the extra-intestinal systems such as the nervous system, whose neurological symptoms are evidenced in CD patients. A gluten-free diet (GFD) could avoid cerebellar ataxia, epilepsy, neuropathies, migraine and mild cognitive impairment. Furthermore, untreated CD patients have more symptoms and psychiatric co-morbidities than those treated with a GFD. Common psychiatric symptoms in untreated CD adult patients include depression, apathy, anxiety, and irritability and schizophrenia is also common in untreated CD. Several studies show improvement in psychiatric symptoms after the start of a GFD. The present review discusses the state of the art regarding neurological and psychiatric complications in CD and highlights the evidence supporting a role for GFD in reducing neurological and psychiatric complications.

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Section: Neurological Complications and Cognitive Impairment In Coelimentioning

confidence: 99%

“…A recent study evaluated the role of a GFD on neurological symptoms, EEG characteristics and sleep breathing disorders (SBD) in children with CD (61) . The authors enrolled nineteen children with a new biopsy CD diagnosis.…”

Section: Neurological Complications and Cognitive Impairment In Coelimentioning

confidence: 99%

The progression of coeliac disease: its neurological and psychiatric implications

et al. 2016

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“…Use of antiepileptic drugs together with gluten-free diet may decrease frequency of epileptic attacks 4,5,16 . On the other hand, it was reported that EEG abnormalities improved in a child only with gluten-free diet after 6 months 15 . We found that EEG abnormalities improved in 3 of 4 patients with gluten-free diet and use of antiepileptic drugs.…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, there may be EEG abnormalities in absence of convulsions in CD 2 . It was reported that 48% of children with CD might have abnormal EEG findings 15 . We found this rate as 7.7% in our study, however we did not observe convulsions in any of our patients.…”

Section: Discussionmentioning

confidence: 99%

Neurological findings spectrum in Celiac disease

et al. 2016

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We aimed to provide early diagnosis by determining possible Celiac disease related subclinical or symptomatic neurological abnormalities in children in order to decrease risk of mortality and morbidity.Children with Celiac disease were assessed with neurological examination, neurophysiological tests and neuroimaging.A total of 65 patients were included in the study. The neurological examination was abnormal in 4 patients. There were EEG abnormalities in 5 patients, VEP was abnormal in 7 patients, BAER was abnormal in 1 patient, ENMG was abnormal in 8 patients, and there were abnormal findings on neuroimaging in 2 patients.The Celiac disease related neurological complications that manifest in adulthood usually lay their foundations in childhood. Therefore, it must be kept in mind that subclinical neurological abnormalities may be related to Celiac disease, and Celiac disease may be the underlying cause in the patients with overt neurological abnormalities in childhood.

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“…При повторном обсле-довании через 6 мес. соблюдения строгой безглютеновой диеты изменения на ЭЭГ исчезли у 77,1% пациентов [19]. Аналогичная работа была проведена турецкими авторами.…”

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Efficacy of Gluten-Free Diet in Patients With Neurological Diseases and Psychiatric Disorders: Myth or Reality?

Дмитриева¹,

Захарова²

2018

Med. sov.

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Вопрос о том, каким образом употребление глютена может быть связано с различными нарушениями здоровья человека, включая неврологические заболевания, продолжает активно обсуждаться в научных и общественных кругах. Особый интерес представляет перспектива использования безглютеновой диеты в комплексной терапии таких заболеваний, как аутизм, шизофрения, а также пограничных неврологических расстройств, включая синдром хронической усталости, раз-личные когнитивные нарушения, депрессию и т.д. В статье представлен обзор результатов исследований в отношении эффективности безглютеновой диеты при различных неврологических заболеваниях и психиатрических расстройствах, а также рассмотрены потенциальные механизмы нейротропного действия глютена.Ключевые слова: глютен, целиакия, неврологические заболевания, аутизм, шизофрения, безглютеновая диета. Yu.A. DMITRIEVA, PhD in medicine, I.N. ZAKHAROVA, MD, Prof. Russian Medical Academy of Continuing Postgraduate Education of the Ministry of Health of Russia, Moscow EFFICACY OF GLUTEN-FREE DIET IN PATIENTS WITH NEUROLOGICAL DISEASES AND PSYCHIATRIC DISORDERS: MYTH OR REALITY?How eating gluten may be associated with various disorders of human health including neurological diseases remains a topic of discussion in the academic and civil circles. Application of gluten-free diet is of particular interest for the complex management of diseases such as autism, schizophrenia, and borderline neurological disorders including chronic fatigue syndrome, various cognitive impairments, depression, etc. The article presents a review of the studies of efficacy of gluten-free diet in patients with various neurological diseases and psychiatric disorders; the potential mechanisms of the neurotropic action of gluten are also examined.

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Role of the gluten-free diet on neurological-EEG findings and sleep disordered breathing in children with celiac disease

Abstract: According to our preliminary data, in the presence of unexplained EEG abnormalities and/or other neurological disorders/SDB an atypical or silent CD should also be taken into account.

Cited by 38 publications

References 14 publications

The progression of coeliac disease: its neurological and psychiatric implications

The progression of coeliac disease: its neurological and psychiatric implications

Neurological findings spectrum in Celiac disease

Efficacy of Gluten-Free Diet in Patients With Neurological Diseases and Psychiatric Disorders: Myth or Reality?

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