Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation

Cabrerizo, S.; Cruz, J. P. De La; López-Villodres, Juan Antonio; Muñoz‐Marín, J.; Guerrero, A.; Reyes, José Julio; Labajos, M; Correa, José Antonio González

doi:10.1016/j.jnutbio.2013.08.007

Cited by 43 publications

(48 citation statements)

References 38 publications

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“…More recent studies and reviews, for example, by Oliveras-Lopez et al (2014), Garcia-Martinez et al (2014a, 2014b, Estruch et al (2013), Sofi et al (2010) and Fung et al (2009) fit the same general picture presented by Keys (1970) and Martinez-Gonzales et al (2002) and López-Miranda et al (2010) or Lipworth et al (1997). The phenolic compounds, naturally present in EVOO-s are deemed to be of central importance for these beneficial cardiovascular, according to Estruch et al (2013), Fung et al (2009), Valls et al (2015), antiatherogenic/antiinflammatory, Scoditti et al (2014), Lu et al (2013), Cabrerizo et al (2013), anticancer, Hashim et al (2008), Lamy et al (2014), Hashim et al (2014), antioxidant and antimicrobial effects Cicerale et al (2012), Karaosmanoglu et al (2010), Paiva-Martins et al (2013), Giordano et al (2014).…”

Section: Introductionmentioning

confidence: 60%

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

et al. 2015

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SUMMARY:Within the framework of an incentive to provide labeled extra virgin olive oils as a food supplement in pharmacies, the phenolic profile analysis of extra virgin olive oils obtained from Croatian olive cultivars has been reported. With the aim of increasing the consumption of EVOO-s in northern Croatia, the varieties Bjelica, Buža and Italian Leccino have been studied involving two different agroclimatic locations, over two harvest years differing significantly in the amount of rainfall. The Croatian cultivars Plominka, Žižolera, Oblica and Lastovka, were also examined. Correlation tests and the insight from PCA reveal that the cultivars are highly individualized in character with regard to relationships among phenolic compounds. Some elements of an innovative labeling aimed to better present the authenticity, quality, excellence and uniqueness of the EVOO-s were suggested. KEYWORDS: Autochthonous Croatian olive varieties; Extra virgin olive oil; Labeling; Phenolic compounds RESUMEN:Aceites de oliva virgen extra etiquetados como suplemento alimenticio; compuestos fenólicos en aceites de aceitunas autóctonas croatas. En el marco de los incentivos que se han considerado para proporcionar el etiquetado de aceites de oliva virgen extra como suplemento alimenticio en farmacias, se reporta el análisis del perfil fenólico de aceites de oliva vírgenes extra obtenidos a partir de variedades croatas. Para ampliar el consumo de AOVE-s en el norte de Croacia, se han estudiado las variedades Bjelica, Buža y Leccino italiana procedentes de dos lugares agroclimáticos diferentes que difieren significativamente en la cantidad de lluvia y obtenidos en dos cosechas. Tambien fueron examinados los cultivares croatas Plominka, Žižolera, Oblica y Lastovka. Los test de correlación y los resultados de PCA revelan que las variedades están altamente individualizados en su carácter en lo que respecta a las relaciones entre los compuestos fenólicos. Se sugirieron algunos elementos innovadores para un etiquetado dirigido a presentar mejor la autenticidad, la calidad, la excelencia y la singularidad de los AOVE-s. PALABRAS CLAVE: Aceite de oliva virgen extra; Compuestos fenólicos; Etiquetado; Variedades de aceitunas autóctonas croatasCitation/Cómo citar este artículo: Jakobušić Brala C, Benčić Ð, Šindrak Z, Barbarić M and Uršić S. 2015. Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives. Grasas Aceites 66 (4): e099. doi: http://dx

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Section: Introductionmentioning

confidence: 60%

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

et al. 2015

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“…Oleuropein hydrolysis takes places during olive maturation, as well as during olive oil storage [9,10]. This phenolic bioactive compound has been proved to be endowed with several pharmaceutical properties such as antioxidant, anti-inflammatory, antithrombotic, antidiabetic and hypolipidemic effects [11][12][13][14]. In the current study, we explored, for the first time, the therapeutic efficacy of HT in rats with myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, it has been demonstrated that HT improved the cardiac disturbances enhanced by doxorubicin by significantly reducing the percentage of altered mitochondria also enhancing the mitochondrial electron transport chain and antioxidant defense system [18]. Several previous studies have demonstrated that the myocardium injury induced by isoproterenol in experimental rats is strongly associated with deterioration of hemodynamic and LV contractile function [14][15][16][17]. While, HT pre-and co-treatment showed significant improvement in systolic and diastolic arterial pressure (SAP and DAP, respectively) and subsequent increase in mean arterial pressure (MAP), a marker of after load.…”

Section: St-segment (Mv)mentioning

confidence: 99%

Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat

Mnafgui

Hajji²,

Derbali³

et al. 2015

Cardiovasc Toxicol

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The present study aimed to investigate the cardioprotective effect of hydroxytyrosol (HT) against isoproterenol-induced myocardial infarction in rats. Male rats were randomly divided into four groups, control, isoproterenol (Isop) and pretreated animals with HT in two different doses (2 and 5 mg/kg) orally for 7 days and intoxicated with isoproterenol (Isop + HT1) and (Isop + HT2) groups. Myocardial infarction in rats was induced subcutaneously by isoproterenol (100 mg/kg, s.c.) at an interval of 24 h on 6th and 7th day. On 8th day, electrocardiographic (ECG) pattern, gravimetric and biochemical parameters were assessed. Isoproterenol exhibited changes in ECG pattern, including significant ST-segment elevation and increase in the serum troponin-T level by 317 % as compared to control rats. Moreover, cardiac injury markers (creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase) underwent a notable rise in serum of infarcted animals. Else, a disturbance in lipids profile and significant increase in lipase and angiotensin-converting enzyme (ACE) activities and heart weight ratio were observed in isoproterenol group. However, pre- and co-treatment with HT (2 and 5 mg/kg) improved the myocardium injury, restored the hemodynamic function and inhibited the ACE activity that prevent cardiac hypertrophy and remodeling. Overall, these findings demonstrated that HT exerted a potent cardioprotective effect against isoproterenol-induced myocardial infarction.

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“…The major metabolites of ECH and ACT in plasma in vivo were hydroxytyrosol sulfate conjugation (>56%) and 3-hydroxyphenylpropionic acid sulfate conjugation (>21%), which may be responsible for certain bioactivity. It was reported that HT and 3-hydroxyphenylpropionic acid possesses similar activity against protein glycation , and antioxidant (Gómez-Ruiz et al, 2007;Jemai et al, 2009) and neuroprotective effects (Cabrerizo et al, 2013;Wang et al, 2015), leading to speculatinon that they are important active components by oral administration in vivo. However, whether or not sulfate HT and 3-hydroxyphenylpropionic acid with hydroxy structure display pharmacological activity will need further investigation.…”

Section: Glucuronide Metabolitesmentioning

confidence: 99%

Systematic characterization of the metabolites of echinacoside and acteoside from Cistanche tubulosa in rat plasma, bile, urine and feces based on UPLC‐ESI‐Q‐TOF‐MS

Cui

Pan

Bai

et al. 2016

Biomedical Chromatography

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Echinacoside (ECH) and acteoside (ACT), as the most and major active components of Cistanche tubulosa, were reported to possess cardioactive, neuroprotective and hepatocyte protective effects, as well as antibacterial, antioxidative effects. Recently, more studies have focused on their pharmacological activities. However, their metabolic profiles in vivo have not been sufficiently investigated. This study proposes an approach for rapidly identifying the complicated and unpredictable metabolites of ECH and ACT in rat plasma, bile, urine and feces, and systematically and comprehensively revealing their major metabolic pathways, based on powerful ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Plasma, bile, urine and feces were collected from rats after a single 200 mg/kg oral dose. A total of 49 metabolites were detected in rat biological samples. Through analyzing metabolites in bile samples, it was found that ECH and ACT were subjected to a marked hepatic first-pass effect in liver. Copyright © 2016 John Wiley & Sons, Ltd.

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Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation

Cited by 43 publications

References 38 publications

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat

Systematic characterization of the metabolites of echinacoside and acteoside from Cistanche tubulosa in rat plasma, bile, urine and feces based on UPLC‐ESI‐Q‐TOF‐MS

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