Role of the Innate and Adaptive Immune System in the Pathogenesis of PD

Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's Disease

“…The immune system, especially the central immune system, has recently been recognized as a significant feature of PD pathophysiology. Chronic neuroinflammation, Lewy body inclusions, and loss of dopaminergic neurons in the substantia nigra parts compacta of the midbrain characterize PD pathology (38). Microglial activation and increased expression of inflammatory genes make up the in vivo evidence for neuroinflammation in PD patients.…”