Role of the kinins in vasodilatation of skeletal muscle of the dog

Me, Webster; Ns, Skinner; Wj, Powell

doi:10.1152/ajplegacy.1967.212.3.553

Cited by 14 publications

(5 citation statements)

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“…Carboxypeptidase B, an enzyme capable of abolishing or reducing the vasodilator effects of kinins in vivo (Erdos, Wohler & Levine, 1963;Webster et al 1967) Hg.ml.-100 g-1 min-'). Panel A of this figure shows the changes in vascular resistance induced by bradykinin (left) and by three levels of nerve stimulation (right).…”

Section: Resultsmentioning

confidence: 99%

“…Carboxypeptidase B, chorda tympani nerve stimulation and salivary gland blood flow. Carboxypeptidase B, an enzyme capable of abolishing or reducing the vasodilator effects of kinins in vivo (Erdos, Wohler & Levine, 1963;Webster et al 1967) was used to evaluate the role of kinins in producing the hyperaemia of chorda tympani nerve stimulation. It was reasoned that this enzyme should reduce or abolish the hyperaemia of chorda stimulation if the kinins are responsible for this vasodilatation.…”

Section: Resultsmentioning

confidence: 99%

“…Since previous studies have shown that carboxypeptidase B (Webster et al 1967) and dextrans of comparable molecular weight (Arturson & Kjellmer, 1964) appear in lymph after systemic administration, it is reasonable to assume that carboxypeptidase B enters the interstitial fluid of salivary glands where inactivation of endogenously released kinin could occur. The concentration of carboxypeptidase B in interstitial fluid was not determined and, consequently, no statement can be made relative to the amount of bradykinin that could be destroyed.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to the rapid excretion or metabolism of this enzyme by the kidney (Webster et al 1967), one half of the initial concentration was injected every 20 min so that relatively constant blood levels were maintained. The average blood level (80-170 ,g/ml.…”

Section: Methodsmentioning

confidence: 99%

“…Carboxypeptidase B was prepared from hog pancreas as described previously (Webster, Skinner & Powell, 1967) and an amount of solution equivalent to 10-20 mg of pure carboxypeptidase B was injected intravenously (femoral vein). Owing to the rapid excretion or metabolism of this enzyme by the kidney (Webster et al 1967), one half of the initial concentration was injected every 20 min so that relatively constant blood levels were maintained. The average blood level (80-170 ,g/ml.…”

Section: Introductionmentioning

confidence: 99%

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Kinins, beta‐adrenergic receptors and functional vasodilatation in the submaxillary gland of the cat

Skinner¹,

Webster²

1968

The Journal of Physiology

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SUMMARY1. The close arterial infusion of bradykinin into the submaxillary gland of the cat produced a pronounced hyperaemia that could be blocked by simultaneous perfusion of the gland with blood containing carboxypeptidase B. Carboxypeptidase B, however, failed to reduce the vasodilatation of chorda tympani nerve stimulation suggesting that the kinins are not involved in the regulation of submaxillary gland blood flow.2. Isoproterenol injections produced pronounced salivary gland vasodilatation. Beta-adrenergic blocking drugs reduced or abolished the hyperaemia of isoproterenol and reduced that of chorda tympani nerve stimulation. The combination of beta-blocking drugs and atropine could abolish or reduce further this nerve induced hyperaemia.3. The above results suggest that stimulation of cholinergic and betaadrenergic receptors could account for the chorda tympani induced hyperaemia. Conclusive proof of this possibility remains to be determined.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%