Role of the mesoamygdaloid dopamine projection in emotional learning

Phillips, G. D.; Salussolia, Emily; Hitchcott, Paul Kenneth

doi:10.1007/s00213-010-1813-z

Cited by 11 publications

(8 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NBW females showed a higher DA concentration at the hippocampus than their male littermates. The release of DA, acting on many brain regions including hippocampus and amygdala, mainly influences reward‐related behavior (Packard and White, 1991; Phillips et al, 2010). Hence, the higher levels of DA found in the female NBW piglets of the current study may give more data supporting a better survival and developmental traits of the female sex, as previously found in other studies (Aiken and Ozanne 2013; Moritz et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

Vázquez-Gómez¹,

Valent²,

García-Contreras³

et al. 2016

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

The current study aimed to determine, using a swine model of intrauterine growth restriction (IUGR), whether short- and long-term neurological deficiencies and interactive dysfunctions of Low Birth-Weight (LBW) offspring might be related to altered pattern of neurotransmitters. Hence, we compared the quantities of different neurotransmitters (catecholamines and indoleamines), which were determined by HPLC, at brain structures related to the limbic system (hippocampus and amygdala) in 14 LBW and 10 Normal Body-Weight (NBW) newborn piglets. The results showed, firstly, significant effects of sex on the NBW newborns, with females having higher dopamine (DA) concentrations than males. The IUGR processes affected DA metabolism, with LBW piglets having lower concentrations of noradrenaline at the hippocampus and higher concentrations of the DA metabolites, homovanillic acid (HVA), at both the hippocampus and the amygdala than NBW neonates. The effects of IUGR were modulated by sex; there were no significant differences between LBW and NBW females, but LBW males had higher HVA concentration at the amygdala and higher concentration of 5-hydroxyindoleacetic acid, the serotonin metabolite, at the hippocampus than NBW males. In conclusion, the present study shows that IUGR is mainly related to changes, modulated by sex, in the concentrations of catecholamine neurotransmitters, which are related to adaptation to physical activity and to essential cognitive functions such as learning, memory, reward-motivated behavior and stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

Vázquez-Gómez¹,

Valent²,

García-Contreras³

et al. 2016

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…DA influences reward-related behavior by acting on many brain regions including the prefrontal cortex (Hitchcott et al, 2007), rhinal cortex (Liu et al, 2004), hippocampus (Packard and White, 1991; Grecksch and Matties, 1981) and amygdala (Phillips et al, 2010). The effects of DA are likely to differ widely between these regions due to variations in the density of DA innervation, DA transporters, metabolic enzymes, autoreceptors, receptors, and receptor coupling to intracellular signaling pathways (Neve et al, 2004; Bentivoglio and Morelli, 2005; Frank and Fossella, 2010).…”

Section: Dopamine In Reward: Recent Advancesmentioning

confidence: 99%

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

Bromberg-Martin

Matsumoto

Hikosaka

2010

Neuron

1,971

1,629

View full text Add to dashboard Cite

SUMMARY Midbrain dopamine neurons are well known for their strong responses to rewards and their critical role in positive motivation. It has become increasingly clear, however, that dopamine neurons also transmit signals related to salient but non-rewarding experiences such as aversive and alerting events. Here we review recent advances in understanding the reward and non-reward functions of dopamine. Based on this data, we propose that dopamine neurons come in multiple types that are connected with distinct brain networks and have distinct roles in motivational control. Some dopamine neurons encode motivational value, supporting brain networks for seeking, evaluation, and value learning. Others encode motivational salience, supporting brain networks for orienting, cognition, and general motivation. Both types of dopamine neurons are augmented by an alerting signal involved in rapid detection of potentially important sensory cues. We hypothesize that these dopaminergic pathways for value, salience, and alerting cooperate to support adaptive behavior.

show abstract

“…DA in the prefrontal cortex appears to affect working memory and impulsivity (Goldman-Rakic, 1990; Dagher and Robbins, 2009; Cools and D’Esposito, 2011; Dalley et al, 2011) while in the amygdala it may be critical for the modulation of emotional learning (Lamont and Kokkinidis, 1998; Rosenkranz and Grace, 2002; Fadok et al, 2010; Phillips et al, 2010; Tye et al, 2010). Taken together, the effects of manipulation of the DA system clearly depend upon which DAergic projection is affected.…”

Section: Dopamine and Behaviormentioning

confidence: 99%

Establishing causality for dopamine in neural function and behavior with optogenetics

Steinberg

Janak

2013

Brain Research

View full text Add to dashboard Cite

Dopamine (DA) is known to play essential roles in neural function and behavior. Accordingly, DA neurons have been the focus of intense experimental investigation that has led to many important advances in our understanding of how DA influences these processes. However, it is becoming increasingly appreciated that delineating the precise contributions of DA neurons to cellular, circuit, and systems-level phenomena will require more sophisticated control over their patterns of activity than conventional techniques can provide. Specifically, the roles played by DA neurons are likely to depend on their afferent and efferent connectivity, the timing and length of their neural activation, and the nature of the behavior under investigation. Recently developed optogenetic tools hold great promise for disentangling these complex issues. Here we discuss the use of light-sensitive microbial opsins in the context of outstanding questions in DA research. A major technical advance offered by these proteins is the ability to bidirectionally modulate DA neuron activity in in vitro and in vivo preparations on a time scale that more closely approximates those of neural, perceptual and behavioral events. In addition, continued advances in rodent genetics and viral-mediated gene delivery have contributed to the ability to selectively target DA neurons or their individual afferent and efferent connections. Further, these tools are suitable for use in experimental subjects engaged in complex behaviors. After reviewing the strengths and limitations of optogenetic methodologies, we conclude by describing early efforts in the application of this valuable new approach that demonstrate its potential to improve our understanding of the neural and behavioral functions of DA.

show abstract

Role of the mesoamygdaloid dopamine projection in emotional learning

Abstract: Manipulations of amygdala dopamine impact the earliest stage of learning in which emotional reactions may be most prevalent.

Cited by 11 publications

References 55 publications

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

Sex and intrauterine growth restriction modify brain neurotransmitters profile of newborn piglets

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

Establishing causality for dopamine in neural function and behavior with optogenetics

Contact Info

Product

Resources

About