Role of Thyroid Hormone and Oxidant Stress in Cardiovascular Diseases

Khan, M. Kaleemullah; S, Mukherjee; Bank, Sarbashri; Maiti, Smarajit

doi:10.2174/1871530320666200917114501

Cited by 2 publications

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“…In short, thyroid function was affected not only in COVID-19 patients but also in non-COVID-19 patients during the disease outbreak and citywide lockdown, which was related to stress. Thyroid hormone was increasing in risk factors [ 16 ]. The rise of FT4 in Takotsubo syndrome suggested a stress-dependent endocrine response [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic

Dong

Wang

et al. 2022

International Journal of Endocrinology

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Purpose. This study aimed to determine whether and how stress-induced thyroid hormone changes occur during the COVID-19 pandemic in the northern area of Tianjin. Methods. This study comprised two groups of study subjects in Tianjin: before (2019) and during (2020) the COVID-19 outbreak. Subjects were included if they had FT3, FT4, and TSH concentrations and thyroid TPOAb or TgAb information available. People who were pregnant, were lactating, or had mental illness were excluded. We used propensity score matching to form a cohort in which patients had similar baseline characteristics, and their anxiety level was measured by the Hamilton Anxiety Rating Scale (HAMA). Results. Among the 1395 eligible people, 224 in Group A and 224 in Group B had similar propensity scores and were included in the analyses. The detection rate of abnormal thyroid function was decreased in pandemic Group B (69.2% vs. 93.3%, χ2 = 42.725, p < 0.01 ), especially for hypothyroidism (14.29% vs. 35.71%, χ2 = 27.429, p < 0.01 ) and isolated thyroid-related antibodies (25.89% vs. 38.39%, χ2 = 8.023, p < 0.01 ). The level of FT4 (z = −2.821, p < 0.01 ) and HAMA score (7.63 ± 2.07 vs. 5.40 ± 1.65, t = 16.873, p < 0.01 ) went up in Group B; however, TSH (z = −5.238, p < 0.01 ), FT3 (z = −3.089, p = 0.002 ), TgAb (z = −11.814, p < 0.01 ), and TPOAb (z = −9.299, p < 0.01 ) were lower, and HAMA was positive with FT3 (r = 0.208, p < 0.01 ) and FT4 (r = 0.247, p < 0.01 ). Conclusion. People in the northern area of Tianjin during the COVID-19 outbreak were at an increased risk of higher FT4, lower FT3, and lower TSH. The HAMA scores increased in emergency situations and were positively correlated with the levels of FT3 and FT4.

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Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic

Dong

Wang

et al. 2022

International Journal of Endocrinology

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Antioxidant effects of the synthetic thyronamine analogue in experimental cerebral ischemia

Filimonov,

Eresko,

Raksha

et al. 2024

MES

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The oxidative stress associated with ischemic stroke is a major factor damaging the nervous tissue. Thyroid hormones have a significant effect on the body’s redox status, however, the impact of their derivatives, thyronamines, considered as potential neuroprotectors, on the characteristics of lipid peroxidation (LP) is not clearly understood. The study was aimed to assess the impact of the Т0АМ thyronamine synthetic analogue on the main LP indicators in the model of acute cerebral ischemia. Permanent ligation of the right common carotid artery was performed to simulate acute cerebral ischemia in white rats. The animals were divided into two groups: the control group receiving no treatment and the experimental group, to which the Т0АМ thyronamine synthetic analogue was intraperitoneally administrated (75 mg/kg of the rat’s body weight). After 24 h the rat was decapitated, and the cerebral cortex tissue was extracted for biochemical analysis. The following LP indicators were determined by spectrophotometry: malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx). When administering the Т0АМ thyronamine synthetic analogue, a significant (2-fold) decrease in MDA levels was observed in the ischemic hemisphere (р = 0.022), along with the 2.49-fold increase in the GPx activity in the brain tissue (р = 0.004) of the intact hemisphere and the 2.65-fold increase in its activity (р = 0.021) in the ischemic hemisphere, as well as the 1.23-fold increase in SOD activity in the ischemic hemisphere (р = 0.042). The Т0АМ thyronamine synthetic analogue has a great potential in terms of activation of the antioxidant protection mechanisms in the cerebral cortex of white laboratory rats under conditions of acute hemispheric ischemia.

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Role of Thyroid Hormone and Oxidant Stress in Cardiovascular Diseases

Cited by 2 publications

References 0 publications

Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic

Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic

Antioxidant effects of the synthetic thyronamine analogue in experimental cerebral ischemia

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