Role of tissue growth factors in aqueous humor homeostasis

Welge–Lüßen, Ulrich; May, Christian Albrecht; Neubauer, A. S.; Priglinger, Siegfried

doi:10.1097/00055735-200104000-00003

Cited by 52 publications

(33 citation statements)

References 31 publications

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“…It is important for the maintenance of both physiological function and metabolic homeostasis of anterior chamber structures including the corneal endothelium, trabecular meshwork, iris, and lens. 2 Previous studies have described alterations in the cytokine and chemokine compositions of the aqueous humor in various ocular diseases, such as uveitis, 3 branch retinal vein occlusion, 4 and age-related macular degeneration. 5 Increased levels of tumor necrosis factor (TNF)-a, 6 transforming growth factor (TGF)-b2, 7 interleukin (IL)-6, 8 IL-8, 8,9 serum amyloid A (SAA), 10 and vascular endothelial growth factor (VEGF) 11 have also been reported in glaucomatous aqueous humor.…”

Section: Resultsmentioning

confidence: 99%

Inflammation-Related Cytokines of Aqueous Humor in Acute Primary Angle-Closure Eyes

Huang¹,

Chen²,

Gao³

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To measure levels of various inflammation-related cytokines in the aqueous humor of patients with acute primary angle-closure (APAC) and senile cataract.METHODS. Aqueous humor samples were prospectively collected from 23 eyes (12 eyes with current APAC and 11 eyes with previous APAC) of 23 APAC patients and 15 eyes of 15 cataract patients. The levels of 15 inflammation-related cytokines in the aqueous humor of APAC and cataract subjects were measured by using the multiplex bead immunoassay technique. Data on patient demographics and preoperative intraocular pressure (IOP) were also collected for correlation analysis.

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Section: Resultsmentioning

confidence: 99%

Inflammation-Related Cytokines of Aqueous Humor in Acute Primary Angle-Closure Eyes

Huang¹,

Chen²,

Gao³

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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“…8,9 Growth factors such as PDGF, FGF, and TGF-b are important for the growth of fibroblasts and blood vessels. 7 When macrophages encounter large foreign bodies, they may fuse to form a large multinucleated cell called the FBGC, the primary cellular mediators of the foreign body response.…”

Section: Discussionmentioning

confidence: 99%

Foreign Body Reaction in Glaucoma Drainage Implant Surgery

Jung

Lee

Kim

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the histopathology of the foreign body reaction (FBR) and the effect of aqueous humor on it in glaucoma drainage implant surgery. METHODS.A glaucoma drainage device was implanted into 20 New Zealand white rabbits. We monitored the histopathology of blebs at microscopic levels from 3 days to 8 weeks postoperatively. Hematoxylin and eosin staining, Masson's trichrome staining, anti-actin and a-smooth muscle immunofluorescence staining, and antiproliferating cell nuclear antigen immunohistochemistry were performed. To observe effects of aqueous humor on FBR, we designed two implant models. One group received a plate with a tube placed in the anterior chamber (experimental group), whereas the other received the plate cut from the tube (control group).RESULTS. Foreign body giant cells were found along the inner border of blebs, and the innermost layer of blebs demonstrated a densely packed collagenous stratum in both groups. The number of foreign body giant cells was suppressed in the experimental group compared with the control group (P < 0.001). Fibroblast division was more active in the experimental group than that in the control group. Masson's trichrome staining demonstrated that the innermost avascular collagenous layer was much thicker in the experimental group than that in the control group (P ¼ 0.021). The extent of a-SMA staining was greater in the experimental group than that in the control group.CONCLUSIONS. In the aqueous humor environment, wound healing around a glaucoma drainage implant revealed a unique FBR with the relatively small number of foreign body giant cells and reinforced fibrotic encapsulation.

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“…22,23 There has been increasing interest in the role of proteins, including transforming growth factor beta (TGFb) and connective tissue growth factor (CTGF), in AqH homeostasis leading to raised IOP and glaucoma. 24, 25 Junglas et al 26 have used a transgenic mouse model to show that CTGF expressed in the AqH elevates IOP, which is associated with TM actin cytoskeleton modification. CTGF is a matricellular protein in that it interacts with and is induced by TGFb and it is through CTGF that TGFb mediates some of the downstream effects on proliferation, migration, and ECM production.…”

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confidence: 99%