Role of Toll-Like Receptor Gene Polymorphisms in Patients with Type 2 Diabetes and Diabetic Foot Ulcer

Al-karawi, Furqan Naeem; AL-Hasnawi, Abeer Thaher Naji; Al-Kashwan, Thekra A.

doi:10.5958/0976-5506.2019.01466.9

Cited by 1 publication

(2 citation statements)

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“…The results revealed that theThr399Ile polymorphisms were not associated with a diabetic foot ulcer in type 2 Iraqi diabetic patients (Al-Karawi et al, 2019). Asp299Gly (rs4986790) and Thr399Ile (rs4986791) SNPs affect the TLR4 mediated effector functions in a variety of ways like reducing the binding efficiency of TLR4 with its endogenous and exogenous ligands (Singh et al, 2013), or reduce the extracellular accumulation causing inadequate TLR4 signaling in response to microbial infection (Prohinar et al, 2010).…”

Section: Toll-like Receptor Gene (Thr399ile Polymorphism)mentioning

confidence: 99%

“…Furthermore, it might reduce the extracellular buildup of functional TLR4 thereby causing poor TLR4 signaling in response to microbial infection (Singh et al, 2013). The effect of TLR 4 polymorphism was studied in a case-control study included 120 Iraqi patients by Al-karawi et al (2019) that assessed whether Thr399Ile polymorphism in TLR-4genes is related to DFU in a sample of Iraqi patients having type 2 diabetes mellitus (T2DM).…”

Section: Toll-like Receptor Gene (Thr399ile Polymorphism)mentioning

confidence: 99%

See 1 more Smart Citation

Genetic polymorphisms associated with diabetic foot ulcer: A review article

Mohammed¹,

Jasim²

2020

Asian J Pharm Pharmacol

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Recently, microRNAs (miRNAs) which are non-coding small RNAs that negatively control gene expressions displayed an important role in the regulation of gene expression in various cells of the skin, including stem cells, immune cells, and keratinocytes (Xu et al., 2014). Moreover, several miRNAs were shown to be differentially expressed in diabetic skins and their expression levels varied during the wound healing process (Madhyastha et al., 2012). For instance, miRNA-126 depletion causes defective endothelial cell proliferation, migration, and angiogenesis contributed by elevated levels of miRNA-503 which is specially grown in diabetes resulting in impaired wound healing via persistent

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Section: Toll-like Receptor Gene (Thr399ile Polymorphism)mentioning

confidence: 99%

Section: Toll-like Receptor Gene (Thr399ile Polymorphism)mentioning

confidence: 99%