Role of topical Sucralfate in healing of burn wounds

Koshariya, Mahim; Shitole, Abhishek; Agarwal, Vishnu; Dave, S.

doi:10.18203/2349-2902.isj20183409

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Sucralfate is better than SDD in the formation of cell granulation (6-17 days vs 14-22 days), reepithelialization (11-22 days vs. 15-30 days), and wound healing (50-75% vs 35-50%). Sucralfate is also more minimal in the incidence of secondary infections, and also reduces pain (Koshariya et al, 2018). In this study respondents claimed to use ondansentron which is considered to have the same function as sucralfate, so this needs to be straightened out.…”

Section: Local Materials Used As a Topical Medication For Burnsmentioning

confidence: 90%

“…The ideal topical burn agent must be stable in a wide range of temperatures, pH and not easily inactivated by blood, pus, or fluid; does not cause scarring and does not stay long in the tissue; open technique so it is easy to monitor injuries; not cytotoxic; easy to apply and easy to dispose of; does not cause anaerobic infection; and not irritating (Koshariya et al, 2018).…”

Section: Local Materials Used As a Topical Medication For Burnsmentioning

confidence: 99%

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Topical Agents Used by Housewives as First Aid Burns in Sleman District Yogyakarta Indonesia

Nofiyanto

Nirmalasari

2020

JKRY

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Burns are the most potential type of injury experienced by housewives. The use of topical agents for first aid burns that are inappropriate or not standardized can worsen the condition. This purpose of this study was to determine the used of topical first aid agents for burns to housewives. This was a descriptive observational study, included 84 respondents were selected using simple random sampling technique with the criteria of housewives who are still actively doing activities in the kitchen, as well as other household activities. Questionnaire was used to collecting the data. The data was analysis descriptively. The average age of respondents was 43.63 years (SD 11.46), most burns occurred while cooking 61 (73.5%), the most common cause was exposure to hot oil 54 (64.3%), the highest frequency was less than 5 times a year 50 (60.2%), most suffered injuries in the hand area of 49 (59%), with the most injuries being 1-3 cm 42 (50.6%), the wound condition was mostly 58 (69.9%), and recovered well, with little trace of 65 (78.3%). The most risky household activity is cooking 69 (82.1%). Nearly all 82 respondents (97.6%) practiced the use of topical agents for burns, with the most use being toothpaste 34 (41.5%), while the herbs commonly used were Aloe vera, as many as 19 (23.2% ). There is still the practice of using topical agents for burns that have not been standardize /not quite right on housewives in the Sleman district.

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Section: Local Materials Used As a Topical Medication For Burnsmentioning

confidence: 90%

Section: Local Materials Used As a Topical Medication For Burnsmentioning

confidence: 99%

Topical Agents Used by Housewives as First Aid Burns in Sleman District Yogyakarta Indonesia

Nofiyanto

Nirmalasari

2020

JKRY

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“…Hospital Bhopal [33] divided 50 patients deep burn injury into group one (sucralfate) and group two [a-sucralfate; b-silver sulfadiazine (SSD)]. The demographics, history, physical, and systemic examinations of the patients were recorded.…”

Section: Department Of General Surgery Hamidiamentioning

confidence: 99%

A Systematic Review: Topical Sucralfate for Burn Wound

Lumintang

Adnyana

Riasa

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Topical sucralfate has been used for burn and non-burn skin and mucosal lesion with remarkable results. The healing rate of mucosa is faster than skin lesion. AIM: A current systematic review was conducted to objectively evaluate wound healing benefits of topical sucralfate for burn wound and to show on which degree of burn wound it works compare with another topical agents of burn wound therapy. METHODS: Databases were searched for relevant studies: Google Scholar, PUBMED, and ProQuest. Data sources were searched using MeSH terms: “topical sucralfate” and “burn wound” for all publications up to December 2018. All English papers were included. Only studies performed in humans were included in this study. A total of 2437 publications were found, of which 3 studies met the inclusion criteria and were relevant to be used in this systematic review. The primary outcome was burn wound healing. DATA EXTRACTION: Data from retrieved studies were reviewed and tabulated according to year of publication, study design, human or animal studies, characteristics of the population, and outcomes. DATA SYNTHESIS: A total of 2 randomized controlled trials (RCTs) and 1 observational comparative study were found. All trials are on second degree burn wound patients. Jadad score was used to assess the methodological quality of the RCTs. One RCT and one comparative study demonstrated favorable outcomes with the use of topical sucralfate. There is one publication with no significant differences. CONCLUSIONS: This systematic review shows a noticeably beneficial effect of topical sucralfate for burn wound. It is better than other topical agent in wound healing rate, decreased infection rate and enhancement of epithelialization also granulation with no local or systemic adverse reactions. However, multicenter RCT with larger sample size are needed to make recommendation for burn wound treatment.

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“…Sucralfate is a sucrose sulphate and aluminium hydroxide complex that has been widely used to protect and cure gastric mucosa in acid peptic disease. 20 , 21 Sucralfate serves as a mechanical barrier by binding epidermal growth more quickly, causing it to accumulate at wound sites and stimulating epithelial cell proliferation. 22 It also promotes angiogenesis, which aids wound healing by increasing tissue granulation.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: A systematic review, meta‐analysis, and meta‐regression of randomised clinical trials

Rudiman

Hanafi

Evan

et al. 2022

International Wound Journal

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Pain and wound after haemorrhoidectomy constantly bothered the patient's convenience. Recurrently, topical sucralfate is used to treat excoriations and burns. It is considered to enhance epidermal growth and tissue granulation, thus, alleviating patients' problems. This study evaluated topical sucralfate's feasibility, safety, and superiority after haemorrhoidectomy. We searched randomised controlled trial (RCT) studies in PubMed, Google Scholar, Europe PMC, and ClinicalTrials.gov until March 29th, 2022. We investigated the influence of topical sucralfate on pain score postoperatively (24 hours, 7 days, and 14 days), pethidine usage, diclofenac usage, and wound healing rate compared to placebo. This study was conducted following the PRISMA guidelines. This study sorted the final six studies with 439 patients underwent haemorrhoidectomy. Topical sucralfate demonstrated significant outcomes on VAS 24 hours post-operative [Std. Mean Difference À1.00 (95% CI À1.70, À0.31), P = .005], VAS 7 days post-operative [Std. Mean Difference À2.29 (95% CI À3.34, À1.25), P < .0001], VAS 14 days post-operative [Std. Mean Difference À1.88 (95% CI À2.74, À1.01), P < .0001], pethidine usage within 24 hours post-operative [Std. Mean Difference À0.62 (95% CI À0.96, À0.27), P = .0004], diclofenac usage 7 days post-operative [Std. Mean Difference À1.76 (95% CI À2.61, À0.92), P < .0001], diclofenac usage 14 days post-operative [Std. Mean Difference À1.64 (95% CI À2.38, À0.91), P < .0001], and wound healing rate at 28-day post-operative [RR 1.45 (95% CI 1.25-1.68), P < .00001]. Topical sucralfate alleviated pain, improved wound healing, and minimised the usage of pethidine and diclofenac compared to placebo.

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Role of topical Sucralfate in healing of burn wounds

Cited by 6 publications

References 11 publications

Topical Agents Used by Housewives as First Aid Burns in Sleman District Yogyakarta Indonesia

Topical Agents Used by Housewives as First Aid Burns in Sleman District Yogyakarta Indonesia

A Systematic Review: Topical Sucralfate for Burn Wound

The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: A systematic review, meta‐analysis, and meta‐regression of randomised clinical trials

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