Role of Traditional Chinese Medicine in Bone Regeneration and Osteoporosis

Abstract

According to World Health Organization (WHO), osteoporosis is a systematic bone disability marked by reduced bone mass and microarchitectural degeneration of osseous cells, which leads to increased bones feebleness and fractures vulnerability. It is a polygenetic, physiological bone deformity that frequently leads to osteoporotic fractures and raises the risk of fractures in minimal trauma. Additionally, the molecular changes that cause osteoporosis are linked to decreased fracture repair and delayed bone regeneration. Bones have the ability to regenerate as part of the healing mechanism after an accident or trauma, including musculoskeletal growth and ongoing remodeling throughout adulthood. The principal treatment approaches for bone loss illnesses, such as osteoporosis, are hormone replacement therapy (HRT) and bisphosphonates. In this review, we searched literature regarding the Traditional Chinese medicines (TCM) in osteoporosis and bone regeneration. The literature results are summarized in this review for osteoporosis and bone regeneration. Traditional Chinese medicines (TCM) have grown in popularity as a result of its success in curing ailments while causing minimal adverse effects. Natural Chinese medicine has already been utilized to cure various types of orthopedic illnesses, notably osteoporosis, bone fractures and rheumatism with great success. TCM is a discipline of conventional remedy that encompasses herbal medication, massage (tui na), acupuncture, food, and exercise (qigong) therapy. It is based on more than 2,500 years of Chinese healthcare profession. This article serves as a comprehensive review summarizing the osteoporosis, bone regeneration and the traditional Chinese medicines used since ancient times for the management of osteoporosis and bone regeneration.

Osteogenesis promotion by injectable methacryloylated gelatin containing psoralen and its bacteriostatic properties

“…In recent years statins and herbal preparations have played a positive role in the oral cavity, but studies have confirmed that the administration of high doses (27 mg/kg) of atorvastatin prevented alveolar bone loss, but low doses (below 3 mg/kg) of atorvastatin increased bone resorption [25]. Chinese medicine has unique advantages in bone regeneration, and numerous studies have confirmed [26,27] that Chinese medicine can promote bone regeneration through multiple mechanisms or targets. Chinese herbal medicine avoids the drug resistance associated with antibiotics and chemically synthesised drugs, has less toxic side effects [28], and is suitable for the longterm treatment of periodontal disease.…”

PDGF-loaded microneedles promote tendon healing through p38/cyclin D1 pathway mediated angiogenesis

“…Alphafold v2.0 ( https://alphafold.ebi.ac.uk/ ) was adopted to build structure of PDGFR as an artificial intelligence prediction tool as conduct in previous studies [ 23 ]. The amino acid sequences of PDGFR were obtained from the UniProt-KB database ( http://www.uniprot.org/ ).…”

PLGA/BGP/Nef Porous Composite Restrains Osteoclasts by Inhibiting the NF-κB Pathway, Enhances IGF-1-mediated Osteogenic Differentiation and Promotes Bone Regeneration

“…In recent years, many compounds derived from natural plants have shown multiple biological properties, including antioxidant, anti-in ammatory and anticancer effects. Some of these compounds have also been shown to exert potent anti-osteoclasts and osteogenesis effects [11]. There are many traditional Chinese medicines that have effects on bone repair.…”