2011
DOI: 10.1515/rns.2011.034
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Role of transcription factors in neurogenesis after cerebral ischemia

Abstract: Studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after cerebral ischemia. And this perspective on neurogenesis adds to the conceptual framework for strategies for the repair of ischemia-induced brain injury, that is, if the effect of ischemia-induced neurogenesis is enhanced, then the recovery of brain function after stroke can be promoted. Neurogenesis is a multistep process that requires the proliferation of neural stem/progenitor cells, migration and that new … Show more

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Cited by 24 publications
(13 citation statements)
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“…Furthermore, we found that genes involved in cell differentiation, including RELN, BMP4, NODAL and NTRK3, and tissue remodeling and wound repair are dysregulated in adults. Though the literature on adult neurogenesis and cell differentiation is sparse, recent studies propose that the brain activates these mechanisms in response to injury in the neocortex [66], [67]. In the context of brain overgrowth, these data suggest the hypothesis that reactive reorganization of functional genetic networks and processes may occur in the adult autistic brain.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, we found that genes involved in cell differentiation, including RELN, BMP4, NODAL and NTRK3, and tissue remodeling and wound repair are dysregulated in adults. Though the literature on adult neurogenesis and cell differentiation is sparse, recent studies propose that the brain activates these mechanisms in response to injury in the neocortex [66], [67]. In the context of brain overgrowth, these data suggest the hypothesis that reactive reorganization of functional genetic networks and processes may occur in the adult autistic brain.…”
Section: Discussionmentioning
confidence: 99%
“…10 We also found that not only could tLLLT reduce the number of neurons undergoing degeneration (via Fluoro-Jade staining), suggesting neuroprotection, but that tLLLT could also increase bromodeoxyuridine (BrdU) positive cells in the vicinity of the brain lesion, 12 suggesting that the neurological improvement may be partly explained by the process of neurogenesis. 16 Lately, adult neurogenesis has become a major topic of investigation in multiple classes of brain disease, including trauma [17][18] degenerative diseases, 19 and psychiatric disorders. 20 Many studies have suggested 21 that the areas of the mammalian brain that are particularly specialized to produce proliferating neuroprogenitor cells are the subgranular layer of the dentate gyrus (DG) in the hippocampus, 22 and the subventricular zone of the lateral ventricle.…”
Section: Introductionmentioning
confidence: 99%
“…Defects or impairments in embryonic and neonatal neurogenesis contribute significantly to a large range of neuropsychiatric diseases including intellectual disability (mental retardation), autism spectrum disorders, childhood-onset schizophrenia, epilepsy, pediatric bipolar disorder, attention-deficit hyperactivity disorder, as well as genetic or neurodevelopmental disorders such as Fragile X syndrome, Rett syndrome, Down syndrome, Hirschsprung’s disease (Heanue and Pachnis, 2007; Vaillend et al, 2008; Ma et al, 2009; Schäfer et al, 2009; Kishi and Macklis, 2010; Callan and Zarnescu, 2011). Adult neurogenesis is a relatively new concept and abnormal adult neurogenesis plays an important role in the pathogenesis of many cognitive/mood dysfunction in adult such as depression (Hanson et al, 2011), schizophrenia (Inta et al, 2011), epilepsy (Andres-Mach et al, 2011), stroke (Zhang et al, 2011), HIV-associated neurocognitive disorders (Okamoto et al, 2007; Kaul, 2008) and neurodegenerative diseases including Alzheimer’s disease (Mu and Gage, 2011), Parkinson’s disease (van den Berge et al, 2011), multiple sclerosis (Huehnchen et al, 2011; Tepavčević et al, 2011), and others (Winner et al, 2011; Curtis et al, 2012). …”
Section: Introductionmentioning
confidence: 99%
“…Several signaling pathways such as Wnt/β-catenin, Notch, sonic hedgehog (Shh) as well as transcriptional factors such as Sox2, Pax6, Mash1, TLX, Hes1/5, NeuroD, Tbr2, etc. in neurogenesis have been identified (Ma et al, 2009; Hodge and Hevner, 2011), but little is known about the signaling of nuclear factor κB (NFκB) during neurogenesis (Schölzke and Schwaninger, 2007; Widera et al, 2008; Kaltschmidt and Kaltschmidt, 2009; Gutierrez and Davies, 2011; Zhang et al, 2011). Recently, inflammatory mediators including cytokines, chemokines, growth factors, adhesion molecules, are receiving increased attentions in the field of embryonic and adult neurogenesis because inflammatory and immune responses are known to play critical roles in various diseases and injuries of the nervous system (Das and Basu, 2008; Taupin, 2008; Widera et al, 2008; Whitney et al, 2009; Teng and Tang, 2010).…”
Section: Introductionmentioning
confidence: 99%