“…Defects or impairments in embryonic and neonatal neurogenesis contribute significantly to a large range of neuropsychiatric diseases including intellectual disability (mental retardation), autism spectrum disorders, childhood-onset schizophrenia, epilepsy, pediatric bipolar disorder, attention-deficit hyperactivity disorder, as well as genetic or neurodevelopmental disorders such as Fragile X syndrome, Rett syndrome, Down syndrome, Hirschsprung’s disease (Heanue and Pachnis, 2007; Vaillend et al, 2008; Ma et al, 2009; Schäfer et al, 2009; Kishi and Macklis, 2010; Callan and Zarnescu, 2011). Adult neurogenesis is a relatively new concept and abnormal adult neurogenesis plays an important role in the pathogenesis of many cognitive/mood dysfunction in adult such as depression (Hanson et al, 2011), schizophrenia (Inta et al, 2011), epilepsy (Andres-Mach et al, 2011), stroke (Zhang et al, 2011), HIV-associated neurocognitive disorders (Okamoto et al, 2007; Kaul, 2008) and neurodegenerative diseases including Alzheimer’s disease (Mu and Gage, 2011), Parkinson’s disease (van den Berge et al, 2011), multiple sclerosis (Huehnchen et al, 2011; Tepavčević et al, 2011), and others (Winner et al, 2011; Curtis et al, 2012). …”