Role of Ultrasound and Other Advanced Imaging in the Diagnosis and Management of Gout

Thiele, Ralf

doi:10.1007/s11926-010-0156-4

Cited by 86 publications

(49 citation statements)

References 34 publications

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“…17 Imaging techniques for diagnosis and assessment of treatment response include conventional radiography, ultrasound, computed tomography, and magnetic resonance imaging (MRI). 18 Similar to what is seen in rheumatoid arthritis, advanced imaging techniques (eg, MRI and ultrasound) appear to be more sensitive for destructive arthropathy. 18 However, there is concern regarding the risk of nephrogenic systemic fibrosis in patients with reduced renal function after exposure to a gadolinium-based contrast agent.…”

Section: Diagnosis and Clinical Featuresmentioning

confidence: 90%

“…18 Similar to what is seen in rheumatoid arthritis, advanced imaging techniques (eg, MRI and ultrasound) appear to be more sensitive for destructive arthropathy. 18 However, there is concern regarding the risk of nephrogenic systemic fibrosis in patients with reduced renal function after exposure to a gadolinium-based contrast agent. 19 The differential diagnosis for gouty arthritis includes pseudogout, septic arthritis, psoriatic arthritis, nodal osteoarthritis, and reactive arthritis.…”

Section: Diagnosis and Clinical Featuresmentioning

confidence: 90%

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Gouty arthritis: Understanding the disease state and management options in primary care

Sunkureddi

2011

Adv Therapy

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Acute gouty arthritis is an inflammatory response triggered by the release of monosodium urate crystal deposits into the joint space. The disease is associated with debilitating clinical symptoms and functional impairments as well as adverse economic and quality-of-life burdens. Because gouty arthritis is typically diagnosed and managed in the primary care setting, clinicians require a thorough knowledge of the presenting clinical features, risk factors, differential diagnoses, and treatment options for appropriate management. Although generally effective, the use of currently available therapies to control gouty arthritis is challenging because many medications used to treat comorbidities can exacerbate gouty arthritis and because current agents are associated with a number of adverse events, contraindications, or both. Based on an understanding of the underlying inflammatory pathogenesis of gouty arthritis, several new agents are being developed that may provide improved efficacy.

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Section: Diagnosis and Clinical Featuresmentioning

confidence: 90%

Section: Diagnosis and Clinical Featuresmentioning

confidence: 90%

Gouty arthritis: Understanding the disease state and management options in primary care

Sunkureddi

2011

Adv Therapy

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“…36 On ultrasonography (USG), MSU crystals may appear within the synovial fluid as a 'snow storm appearance' or deposit on superficial articular cartilage as the 'double contour sign'. 37 Collection of MSU crystals within tophi can also be identified by USG. Ultrasound features of MSU crystal deposition have high specificity and high positive predictive value.…”

Section: Diagnosismentioning

confidence: 99%

Gout: an Asia‐Pacific update

Paul

James

2017

Int J of Rheum Dis

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Even though, Hippocrates recognized gout as an affection of older men and a product of high living long back in 5th century BC, this painful condition promises to accompany humanity to the 21st century. The incidence is progressively rising and females are also affected in the modern era. There are also regional and ethnic variations in the incidence, the genetics of which is being studied. The recommended best therapy for the acute attacks and long term prophylaxis has improved remarkably in the recent years. However, patients are often treated inadequately and risk factors for their disease are not well explored in daily practice. Although well designed long term studies of current and newer treatment are welcomed, educating doctors especially the primary care physicians who manage majority of gout cases, in optimizing the currently available management options would improve the present care.Key words: disease aetiology and pathogenesis -human, gout, metabolic and crystal arthropathies drug treatment, metabolic and crystal arthropathies epidemiology, metabolic and crystal arthropathies inflammasome.

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“…Advanced imaging modalities including magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), and dual energy CT have important applications in gout and can capture information about the composite, vascular nature of many tophaceous deposits [70][71][72].…”

Section: Mets Hyperuricemia and Nephropathymentioning

confidence: 99%

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study

et al. 2017

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Background Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as nonalcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat). Materials We included 60 male rats and equally divided them to 6 groups of 10 animals in each group: the experimental groups were firstly assigned as controls and high caloric diet (HCD)-fed groups, and each group further was subdivided to remain untreated, Fenugreek bionanocomposite (BNC)-treated, and Orlistat-treated. Normal control rats (groups 1, 2, 3) were fed by a standard chow, while the others (groups 4, 5, 6) were fed with HCD ad libitum during 98 days. From days 77 to 98, groups 2 and 5 were treated with BNC based on Fenugreek (150 mg/kg body weight, orally) and groups 3 and 6 were treated with antiobesogenic drug Orlistat (10 mg/kg body weight, orally). Food and water consumptions were measured daily and body weights were measured once a week. On day 99, blood was collected; the creatinine, urea, and uric acid were estimated in serum according to the standard protocols. Levels of low and middle molecules (MMs) were measured; the quantity of oligopeptides was estimated by Bradford method. We performed the liver and kidney ultrasonography in rats.Results We revealed an increase in the levels of endogenous intoxication syndrome markers (MM and oligopeptides) in all animals with experimental obesity. Ultrasound data showed injury of the liver and kidneys in obese rats. We observed significant decreasing of MM levels after Orlistat treatment vs controls (p < 0.05). However, this effect was more pronounced in Fenugreek BNC-treated group vs both Orlistattreated and controls (p < 0.05). Orlistat treatment evoked rising of serum creatinine and oligopeptides in control animals

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Role of Ultrasound and Other Advanced Imaging in the Diagnosis and Management of Gout

Cited by 86 publications

References 34 publications

Gouty arthritis: Understanding the disease state and management options in primary care

Gouty arthritis: Understanding the disease state and management options in primary care

Gout: an Asia‐Pacific update

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study

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