Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy

Abdallah, Emad; Emile, Sameh Hany; Elfeki, Hossam; Fikry, Mohamed; Abdelshafy, Mahmoud; Elshobaky, Ayman; Elgendy, Hesham; Thabet, Waleed; Youssef, Mohamed A.; Elghadban, Hosam; Lotfy, Ahmed

doi:10.1007/s00595-016-1446-x

Cited by 47 publications

(20 citation statements)

References 28 publications

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“…In our current study, UDCA was significantly decreased in both cholecystolithiasis and non-neoplastic polyps, suggesting that it may have a protective effect on the gallbladder. These results are consistent with previous reports showing that UDCA can prevent gallstones [ 18 , 19 ]. Notably, UDCA is positively correlated with age, but negatively correlated with white blood cell count and Neutrophil percentage.…”

Section: Discussionsupporting

confidence: 94%

Changes in plasma bile acids are associated with gallbladder stones and polyps

Yin-ping

Zhu

et al. 2020

BMC Gastroenterol

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Background The development of gallbladder disease (GBD) is related to bile acid (BA) metabolism, and the rate of BA circulation increases the risk of biliary cancer. However, it is unclear whether patterns of circulating bile acids (BAs) change in patients with benign GBDs such as gallbladder stones and polyps. Herein, we compared and characterised plasma BA profiles in patients with cholecystolithiasis and non-neoplastic polyps with healthy controls, and explored relationships between plasma BA profiles, demographics, and laboratory test indices. Methods A total of 330 subjects (13 healthy controls, 292 cholecystolithiasis and 25 non-neoplastic polyps) were recruited and plasma BA profiles including 14 metabolites from patients with pathologically confirmed cholecystolithiasis and non-neoplastic polyps were compared with controls. BAs were quantitated by liquid chromatography and mass spectrometry, and statistical and regression analyses of demographics and laboratory test indices were performed. Results Females displayed a higher burden of GBD than males (63.36% cholecystolithiasis, 60% non-neoplastic polyps). Cholecystolithiasis and non-neoplastic polyps were associated with increased plasma total secondary BAs, while levels of primary BAs were lower than in healthy controls. Plasma ursodeoxycholic acid (UDCA), tauroursodeoxycholic acid (TUDCA), glycyurdeoxycholic acid (GUDCA), taurochenodeoxycholic acid (TCDCA) and glycochenodeoxycholic acid (GCDCA) were decreased significantly in GBDs, and ursodeoxycholic acid (UDCA) was negatively correlated with white blood cell count and neutrophil percentage. Conclusions Secondary BA levels were higher in patients with cholecystolithiasis and non-neoplastic polyps. White blood cell count and percentage of neutrophil in peripheral blood were negatively correlated with UDCA, indicating an anti-inflammation effect of UDCA.

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Section: Discussionsupporting

confidence: 94%

Changes in plasma bile acids are associated with gallbladder stones and polyps

Yin-ping

Zhu

et al. 2020

BMC Gastroenterol

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“…Diante do exposto, são propostas medidas de rastreamento e prevenção para formação de cálculos biliares e suas complicações. Quanto ao rastreamento, recomenda-se um exame de ultrassom nas primeiras seis semanas como exame de rotina após cirurgia bariátrica para detecção de cálculos biliares (ABDALLAH E, et al, 2017). Tem ganhado destaque como fator protetor para formação de cálculos biliares o uso do ácido ursodeoxicólico ou UDCA, reduzindo assim o risco de se desenvolver complicações de origem biliar (MACHADO FHF, et al, 2019).…”

Section: Revisão Bibliográficaunclassified

Complicações decorrentes de cirurgia bariátrica em adultos jovens

Amaral

Correa²,

Souza

et al. 2021

Acervo Científico

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Objetivo: Analisar na literatura científica sobre as complicações decorrentes de cirurgia bariátrica (CB) em adultos jovens. Revisão bibliográfica: A realização de CB vem crescendo, assim, também as suas complicações pós-cirúrgicas que ocorrem com mais frequência. A CB tem se mostrado o tratamento mais eficaz para obesidade. Dentre eles, pode-se destacar a perda de peso, a redução de comorbidades, e o aumento na expectativa de vida. Porém, como toda operação, a cirurgia bariátrica apresenta riscos e deve ser acompanhada por médicos durante o pré e o pós-operatório, deve-se considerar os riscos de complicações, como vazamento anastomótico, sangramento, abscesso abdominal, obstrução intestinal, dilatação gástrica aguda e ‘’complicações médicas’’ como tromboembolismo, complicação cardiovascular ou pulmonar. Considerações finais: Pacientes submetidos à CB possuem maior risco de desenvolver carências nutritivas pela restrição ao consumir diferentes nutrientes, assim, tendo uma grande importância na vigilância nutricional após a cirurgia. Logo, as indicações cirúrgicas para o tratamento de obesidade, são discutíveis e precisam ser pautadas de acordo com a necessidade que se enquadra no perfil de cada caso.

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“…One of the most studied medications to prevent cholelithiasis formation is UDCA, a secondary bile acid that increases cholesterol solubility in hepatic bile [29]. Several randomized trials have shown that UDCA decreases bile lithogenicity, concluding that UCDA can effectively prevent cholelithiasis and the risk of cholecystectomy after bariatric procedures [30][31][32][33].…”

Section: Routine Postoperative Administration Of Ursodeoxycholic Acidmentioning

confidence: 99%

Systematic review of management of gallbladder disease in patients undergoing minimally invasive bariatric surgery

Leyva‐Alvizo

Arredondo-Saldaña

Leal-Isla-Flores

et al. 2020

Surgery for Obesity and Related Diseases

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Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy

Abstract: The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisposed patients to postoperative CL.

Cited by 47 publications

References 28 publications

Changes in plasma bile acids are associated with gallbladder stones and polyps

Changes in plasma bile acids are associated with gallbladder stones and polyps

Complicações decorrentes de cirurgia bariátrica em adultos jovens

Systematic review of management of gallbladder disease in patients undergoing minimally invasive bariatric surgery

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