Role of vancomycin in the treatment of bacteraemia and meningitis caused by Elizabethkingia meningoseptica

Jean, Shio Shin; Hsieh, Tai Chin; Ning, Yong Zhong; Hsueh, Po-Ren

doi:10.1016/j.ijantimicag.2017.06.021

Cited by 44 publications

(40 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…aureus (MRSA) and Clostridum difficile [ 108 , 109 ]. Gram-negative organisms are normally intrinsically refractory to the action of vancomycin and exhibit MICs > 64 mg/l [ 21 ], except Elizabethkingia , which have been reported to exhibit vancomycin MICs as low as 1 mg/l [ 16 – 19 , 78 , 110 ]. Vancomycin has been used singly or in combination therapies to treat Elizabethkingia infections with mixed success (reviewed in [ 110 ]).…”

Section: Resultsmentioning

confidence: 99%

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens

et al. 2018

View full text Add to dashboard Cite

We report the isolation and characterization of two Elizabethkingia anophelis strains (OSUVM-1 and OSUVM-2) isolated from sources associated with horses in Oklahoma. Both strains appeared susceptible to fluoroquinolones and demonstrated high MICs to all cell wall active antimicrobials including vancomycin, along with aminoglycosides, fusidic acid, chloramphenicol, and tetracycline. Typical of the Elizabethkingia, both draft genomes contained multiple copies of β-lactamase genes as well as genes predicted to function in antimicrobial efflux. Phylogenetic analysis of the draft genomes revealed that OSUVM-1 and OSUVM-2 differ by only 6 SNPs and are in a clade with 3 strains of Elizabethkingia anophelis that were responsible for human infections. These findings therefore raise the possibility that Elizabethkingia might have the potential to move between humans and animals in a manner similar to known zoonotic pathogens.

show abstract

Section: Resultsmentioning

confidence: 99%

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens

et al. 2018

View full text Add to dashboard Cite

show abstract

“…45 Interestingly, clinical cure was noted in patients with Elizabethkingia infection despite high MIC of vancomycin against Elizabethkingia (≥16 mg/L). 23,46 Given the above conflicting data and scant information in literature, it may be necessary to establish the criteria for determining the in vitro antimicrobial susceptibility against Elizabethkingia.…”

Section: Discussionmentioning

confidence: 99%

<p>Molecular Characteristics and Antimicrobial Susceptibility Profiles of <em>Elizabethkingia</em> Clinical Isolates in Shanghai, China</p>

Wang¹,

Zhang²,

Li³

et al. 2020

IDR

View full text Add to dashboard Cite

Purpose: To investigate molecular characteristics and antimicrobial susceptibility profiles of clinical isolates of Elizabethkingia in Shanghai, China. Methods: Elizabethkingia isolates were collected in a university-affiliated hospital in 2012-2015 and 2017-2018. They were re-identified to species level by 16S rRNA gene and species-specific gene sequencing. Antimicrobial susceptibility testing, screening for metallo-beta-lactamase production, identification of antimicrobial resistance genes and pulsed-field gel electrophoresis (PFGE) were performed. Results: Among 52 Elizabethkingia isolates, E. anophelis was the most prevalent species (67.3%), followed by E. meningoseptica (26.9%). High carriage rates of bla CME , bla BlaB and bla GOB genes were consistent with the poor in vitro activity of most β-lactams including carbapenems. Nevertheless, β-lactamase inhibitors increased susceptibility rates significantly for cefoperazone and piperacillin. Susceptibility rates for minocycline, tigecycline, rifampin and levofloxacin were 100%, 78.8%, 76.9% and 71.2%, respectively. Ser83Ile or Ser83Arg substitution in the DNA gyrase A unit was associated with resistance to fluoroquinolones. MIC 50 /MIC 90 values of vancomycin and linezolid were 16/16 mg/L and 16/32 mg/L, respectively. Molecular typing showed twenty-one different types of PFGE and more than one indistinguishable isolates were observed in each of the eight subtypes. Conclusion: Tetracyclines, tigecycline, β-lactam/β-lactamase inhibitor combinations, rifampin and fluoroquinolones demonstrated high rates of in vitro activity against clinical isolates of Elizabethkingia. Both genetic diversity and clonality were observed from this health-care facility. Our report provides potential alternative treatment options for Elizabethkingia infections.

show abstract

“…2,4 Es sensible a las nuevas quinolonas (garenoxacina, gatifloxacina y levofloxacina) y también, pero en menor medida, a rifampicina, trimetoprima/sulfametoxazol y vancomicina. 4,13,14 No obstante, el punto de corte para la susceptibilidad antimicrobiana, según el Clinical and Laboratory Standards Institute, no fue establecido aún. 13 De esta manera, se desconoce la relación entre susceptibilidad in vitro y la respuesta clínica al tratamiento.…”

Section: Discussionunclassified

Neumonía bullosa secundaria a Elizabethkingia meningoseptica, su evolución clínica y radiológica

et al. 2019

View full text Add to dashboard Cite

Presentación de casos clínicos RESUMENElizabethkingia meningoseptica es un patógeno oportunista, con una elevada mortalidad y una incidencia en aumento en las terapias intensivas. Se presenta a una paciente de 4 años con antecedente de atresia de vías biliares y trasplante hepático a los 11 meses de vida, que se internó por infección respiratoria aguda baja con hipoxemia. Durante la internación, sufrió un empeoramiento clínico con requerimiento de asistencia respiratoria mecánica. Por fiebre e hipoxemia persistente, se realizó un minilavado broncoalveolar, con cultivo positivo para Elizabethkingia meningoseptica. Recibió vancomicina, trimetoprima/sulfametoxazol y ciprofloxacina durante 14 días, con buena respuesta. Una tomografía de tórax evidenció la presencia de hipoperfusión en mosaico, imágenes quísticas y bronquiectasias bilaterales. Durante los siguientes 2 años, presentó una buena evolución clínica, con escasas intercurrencias respiratorias, síntomas intercrisis aislados y buena tolerancia al ejercicio. En las imágenes de control, se evidenció la resolución de la mayoría de las lesiones iniciales a los 20 meses de su seguimiento. ABSTRACTElizabethkingia meningoseptica is an opportunistic pathogen with a high mortality and an increasing incidence in the intensive care units. We present a 4-year-old patient with a history of atresia of the biliary tract and a liver transplant at 11 months of age, who was admitted for acute respiratory infection with hypoxemia. During the hospitalization, she required mechanical ventilation. Neumonía bullosa secundaria a Elizabethkingia meningoseptica, su evolución clínica y radiológicaBullous pneumonia secondary to Elizabethkingia meningoseptica, its clinical and radiological evolution Due to persistent fever and hypoxemia, mini bronchoalveolar lavage was performed with a positive culture for Elizabethkingia meningoseptica. She received vancomycin, trimethoprim/sulfamethoxazole and ciprofloxacin for 14 days with a good response. A chest tomography showed the presence of mosaic hypoperfusion, cystic images, and bilateral bronchiectasis. During the following 2 years, she presented good clinical progress, with scarce respiratory infections, isolated symptoms and good tolerance to exercise. The resolution of the majority of the initial lesions was evidenced at 20 months of follow-up.

show abstract

Role of vancomycin in the treatment of bacteraemia and meningitis caused by Elizabethkingia meningoseptica

Cited by 44 publications

References 43 publications

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens

The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens

<p>Molecular Characteristics and Antimicrobial Susceptibility Profiles of <em>Elizabethkingia</em> Clinical Isolates in Shanghai, China</p>

Neumonía bullosa secundaria a Elizabethkingia meningoseptica, su evolución clínica y radiológica

Contact Info

Product

Resources

About