Role of Vascular Endothelial Growth Factor in Clinically Localized Prostate Cancer Treated with Radiation Therapy

Erkal, Eda Yirmibeşoğlu; Bora, Hüseyin; Tepeoğlu, Merıh; Akmansu, Müge

doi:10.5152/balkanmedj.2014.13055

Cited by 3 publications

(1 citation statement)

References 28 publications

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“… 18 Meanwhile, an increased proliferation of cancer cells may result from the promotion or maintenance of cancer vascular system via up-regulated radiation-induced VEGF. 19 , 20 This may contribute to radiation resistance in many ways, including improved interstitial fluid pressure, or vascular permeability, increased oxygen consumption, and hypoxic microenvironment. There is also evidence to support that HIF-1α can enhance the sensitivity of radiation.…”

Section: Hypoxia-inducing Factor 1-alpha and Radiosensitivity Of Nasomentioning

confidence: 99%

Combining antiangiogenic therapy and radiation in nasopharyngeal carcinoma

Chen

2015

SMJ

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Radiation therapy is the primary treatment in nasopharyngeal carcinoma (NPC), and the effect of radiation therapy is strongly related to the oxygen content of cancer cells. That means, it is imperative to balance the interactions between radiotherapy and anti-angiogenesis therapy when giving combination therapy to improve clinical outcomes. The complicated mechanisms between antiangiogenic agents and radiation involve many interactions between the cancer cells, vasculature, and cancer stroma. The proliferation and metastasis of cancer depends on angiogenesis, while rapid growth of cancers will cause hypoxia, which contributes to radioresistance. Antiangiogenic agents can modulate the cancer blood flow and oxygenation through target cancer vasculature, leading to increased radiosensitivity. This study discusses the mechanisms of the synergistic effect of the antiangiogenic therapy with radiation therapy in metastatic NPC, and reviews the data supporting this strategy as a promising treatment for metastatic NPC.

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Section: Hypoxia-inducing Factor 1-alpha and Radiosensitivity Of Nasomentioning

confidence: 99%

Combining antiangiogenic therapy and radiation in nasopharyngeal carcinoma

Chen

2015

SMJ

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Adipokines and Prostate Cancer

Thompson

Reece

2017

Energy Balance and Cancer

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Biomarkers for Evaluation of Prostate Cancer Prognosis

Esfahani¹,

Ataei²,

Panjehpour³

2015

Asian Pacific Journal of Cancer Prevention

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Prostate cancer, with a lifetime prevalence of one in six men, is the second cause of malignancy-related death and the most prevalent cancer in men in many countries. Nowadays, prostate cancer diagnosis is often based on the use of biomarkers, especially prostate-specific antigen (PSA) which can result in enhanced detection at earlier stage and decreasing in the number of metastatic patients. However, because of the low specificity of PSA, unnecessary biopsies and mistaken diagnoses frequently occur. Prostate cancer has various features so prognosis following diagnosis is greatly variable. There is a requirement for new prognostic biomarkers, particularly to differentiate between inactive and aggressive forms of disease, to improve clinical management of prostate cancer. Research continues into finding additional markers that may allow this goal to be attained. We here selected a group of candidate biomarkers including PSA, PSA velocity, percentage free PSA, TGFβ1, AMACR, chromogranin A, IL-6, IGFBPs, PSCA, biomarkers related to cell cycle regulation, apoptosis, PTEN, androgen receptor, cellular adhesion and angiogenesis, and also prognostic biomarkers with Genomic tests for discussion. This provides an outline of biomarkers that are presently of prognostic interest in prostate cancer investigation.

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Role of Vascular Endothelial Growth Factor in Clinically Localized Prostate Cancer Treated with Radiation Therapy

Cited by 3 publications

References 28 publications

Combining antiangiogenic therapy and radiation in nasopharyngeal carcinoma

Combining antiangiogenic therapy and radiation in nasopharyngeal carcinoma

Adipokines and Prostate Cancer

Biomarkers for Evaluation of Prostate Cancer Prognosis

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