Role of vascular endothelial growth factor (VEGF) in endothelial cell protection against cytotoxic agents

Castilla, María Ángeles; Caramelo, Carlos; Gazapo, Rosa; Martı́n, Olga; González-Pacheco, Francisco R.; Tejedor, Alberto; Bragado, Rafael; Arroyo, Μ.

doi:10.1016/s0024-3205(00)00693-7

Cited by 50 publications

(34 citation statements)

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“…VEGF exerts multiple effects on endothelial cells, acting as a mitogen (31,32), promoting cell survival (33,34), and protecting cells from injury (35,36). Taken together with prior evidence for survival-promoting and protective effects of VEGF on neurons, our findings suggest that VEGF regulates a similarly broad range of functions in neurons.…”

Section: Discussionsupporting

confidence: 64%

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

Jin

Zhu

Sun

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

1,382

989

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Section: Discussionsupporting

confidence: 64%

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

Jin

Zhu

Sun

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

1,382

989

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“…Studies have shown that higher expression of VEGF in tumor cells is associated with the development of drug resistance [18][19][20]. The present study showed that in the colon tumor cells of control, untreated group, the expression of VEGF gene was markedly higher than that in normal, healthy control mice.…”

Section: Discussionsupporting

confidence: 44%

Combination of capecitabine and ludartin inhibits colon cancer growth in mice

Huang¹,

Zhong²,

Dan³

et al. 2018

Trop. J. Pharm Res

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“…*p < 0.05 and **p < 0.01 relative to untreated cells. proteins such as EPO and VEGF have also been associated with cytoprotective properties (Castilla et al, 2000;Maiese et al, 2004). It was therefore of interest that the majority of genes upregulated by quercetin were HIF-1 regulated as this may contribute to the cytoprotective properties of this flavonoid.…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells

Radreau

Rhodes

Mithen

et al. 2009

Experimental Eye Research

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Keywords: quercetin flavonoid antioxidant diet lens HIF-1a hypoxia VEGF a b s t r a c t Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and to investigate in detail the mechanisms underlying the responses. FHL-124 cells were treated with quercetin (10 mM) and changes in gene expression were measured by microarray. It was found that 65% of the genes with increased expression were regulated by the hypoxia-inducible factor-1 (HIF-1) pathway. Quercetin (10 and 30 mM) induced a time-dependent increase in HIF-1a protein levels. Quercetin (30 mM) was also responsible for a rapid and long-lasting translocation of HIF-1a from the cytoplasm to the nucleus. Activation of HIF-1 signaling by quercetin was confirmed by qRT-PCR which showed upregulation of the HIF-1 regulated genes EPO, VEGF, PGK1 and BNIP3. Analysis of medium taken from FHL-124 cells showed a sustained dose-dependent increase in VEGF secretion following quercetin treatment. The quercetin-induced increase and nuclear translocation of HIF-1a was reversed by addition of excess iron (100 mM). These results demonstrate that quercetin activates the HIF-1 signaling pathway in human lens epithelial cells.

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Role of vascular endothelial growth factor (VEGF) in endothelial cell protection against cytotoxic agents

Cited by 50 publications

References 0 publications

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

Combination of capecitabine and ludartin inhibits colon cancer growth in mice

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells

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