Role of vascular endothelial growth factor in the pathogenesis of hepatic steatosis and dyslipidemia

Гуляева, И Л; Булатова, И. А.; Пестренин, Л Д

doi:10.25557/0031-2991.2020.04.31-36

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

2020

DOI: 10.25557/0031-2991.2020.04.31-36

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Role of vascular endothelial growth factor in the pathogenesis of hepatic steatosis and dyslipidemia

И Л Гуляева¹,

И. А. Булатова²,

Л Д Пестренин³

Abstract: Цель исследования - изучение роли васкулоэндотелиального фактора роста в патогенезе неалкогольного стеатоза печени и дислипидемии при метаболическом синдроме. Методика. Обследовано 35 пациентов с неалкогольным стеатозом печени, в том числе 22 женщины и 13 мужчин. Группу контроля составили 12 сопоставимых по полу и возрасту лиц без патологии печени и признаков метаболического синдрома. Наличие жирового гепатоза подтверждали методом ультразвукового исследования. У пациентов с патологией печени рассчитывали индек… Show more

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Cited by 3 publications

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Metabolic fatty liver disease as a risk factor for early renal dysfunction in women of reproductive age

Erbes,

Shulkina,

Smirnova

2024

Perm Medical Journal

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Objective. To study the correlation of adipocytokines with early renal dysfunction indicators in women of reproductive age with obesity and metabolic fatty liver disease. Materials and methods. The study included 100 obese females divided into 2 groups. The 1st group consisted of patients (n=50) diagnosed with metabolic fatty liver disease aged 40,5±2,8, and the 2nd group contained patients (n=50) without metabolic fatty liver disease (MFLD). The level of insulin, cystatin C, resistin, leptin, monocyte chemoattractant protein (MCP-1), vascular endothelial growth factor (VEGF), interleukin 6 (IL 6), tumor necrosis factor α (TNF) were determined in blood serum by enzyme-linked immunosorbent assay (ELISA) method. Albumin-to-creatinine ratio, TNF- α, MCP-1, IL 6, cystatin C, b2-microglobulin, VEGF were determined in morning urine. Results. Increased levels of pro-inflammatory cytokines and endothelial dysfunction were revealed in group 1 in relation to both the comparison and control groups. In patients with MFLD associations of resistin level were the following: with HOMA(r=0,60), alanine aminotransferase (ALT) (r=0,54), aspartate aminotransferase (r=0,71), gamma-glutamyl transpeptidase (r=0,71), high-density lipoprotein (HDL) (r=‒0,54), VEGF (r=0,54), TNF- α (r=0,44), MCP-1 (r=0,57) р0,05. In the 1st and 2nd groups cytokine urinary excretion and renal dysfunction markers were higher than in the control group. Associations of urinary excretion of b2-microglobulin with BMI (r=0,33), НОМА (r=0,34), resistin (r=0,30), uric acid level (r=0,50), creatinine (r=0,34), thyroglobulin (r=0,31), urinary MCP-1(r=0,60), IL 6 (r=0,70) р0,05 were revealed in the 1st group. In group 1 associations of urinary IL 6 with BMI (r=0,35), waist/hip circumference (WC/HC) (r=0,33), uric acid level (r=0,44), urinary MCP-1(r=0,74) were positive, and associations with HDL (r=‒0,44) р0,05. Conclusions. Resistin can be considered as an unfavourable marker of cardiometabolic disturbances in patients with MFLD. The association of subclinical inflammation markers and endothelial dysfunction with the markers of early renal impairment in patients with MFLD which was determined allows to expand the understanding of cardio-renal-metabolic continuum.

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Metabolic fatty liver disease as a risk factor for early renal dysfunction in women of reproductive age

Erbes,

Shulkina,

Smirnova

2024

Perm Medical Journal

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Ultrasound Score of Liver Steatosis Severity in the Diagnosis of Peripheral Arterial Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease

Кузнецова

Долгушина

Pospelov

et al. 2023

Arhivʺ vnutrennej mediciny

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Неалкогольная жировая болезнь печени (НАЖБП) является широко распространенным заболеванием, тесно ассоциированным с ожирением и метаболическими нарушениями. В диагностике неалкогольной жировой болезни печени большое внимание уделяется неинвазивным инструментальным маркерам. Целью настоящего исследования было изучение взаимосвязи значений ультразвуковой шкалы стеатоза Hamaguchi с распространенностью атеросклероза периферических артерий, а также оценка диагностической ценности Hamaguchi score в отношении наличия стенозов сонных артерий и артерий нижних конечностей. Материалы и методы. Всем участникам проводили дуплексное сканирование артерий каротидного бассейна и артерий нижних конечностей, абдоминальное ультразвуковое исследование. Резуль таты. В исследовании приняло участие 175 пациентов, среди них 72 мужчины и 103 женщины. Медиана возраста пациентов составила 50 лет. Сочетанный атеросклероз сонных артерий и артерий нижних конечностей выявлен у 76 (43,4 %) пациентов. Медиана выраженности стеатоза печени по шкале Hamaguchi составила 2 балла. В группе пациентов с сочетанным атеросклерозом сонных артерий и артерий нижних конечностей были отмечены достоверно более высокие значения Hamaguchi score (р=0,026). По данным логистического регрессионного анализа увеличение балла по шкале Hamaguchi на одну единицу ассоциировалось с увеличением относительного риска выявления сочетанного атеросклероза двух бассейнов (сонные артерии и артерии нижних конечностей) в 1,192 раза (95 % ДИ 1,023-1,387). По данным ROC-анализа увеличение значений шкалы Hamaguchi более 2 баллов позволяло диагностировать сочетанные стенозы каротидных артерий и артерий нижних конечностей с чувствительностью 52,6 % и специфичностью 63,6 % (AUC=0,596; p=0,024). Заключение. У пациентов с неалкогольной жировой болезнью печени значения шкалы Hamaguchi более 2 баллов позволяет диагностировать сочетанные стенозы каротидных артерий и артерий нижних конечностей с чувствительностью 52,6 % и специфичностью 63,6 %. Ключевые слова: неалкогольная жировая болезнь печени; атеросклероз периферических артерий; шкала Hamaguchi Конфликт интересовАвторы заявляют, что данная работа, её тема, предмет и содержание не затрагивают конкурирующих интересов

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The importance of vascular endothelial growth factor and polymorphism of the VEGF a gene (g634c) in the development of steatosis, fibrosis and cirrhosis of the liver patients in the city of Perm

Булатова

Shevlyukova

Щекотова

et al. 2023

jour

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Introduction. Chronic liver diseases are a significant medical problem all over the world. To date, there is a need to develop a set of laboratory tests, including genetic ones, to determine the risk of development and progression of steatosis, fibrosis and cirrhosis of the liver of various etiologies. Aim: To investigate the serum concentration of vasculoendothelial growth factor (VEGF) and the frequency of occurrence of VEGFA gene polymorphism genotypes in the region -634G/C (rs2010963) in patients with steatosis, fibrosis and cirrhosis of the liver in the Perm Region. Materials and methods: 258 people were examined, including 52 patients with non-alcoholic liver steatosis, 95 patients with chronic hepatitis C and liver fibrosis, 46 people with cirrhosis of the liver of viral (HCV) and alcoholic etiology and 65 practically healthy individuals. The serum concentration of VEGF was determined by enzyme immunoassay. Polymorphisms of the VEGFA gene in region -634G/C were analyzed by polymerase chain reaction. Result: The development of steatosis, fibrosis and cirrhosis of the liver is accompanied by endothelial damage with activation of neoangiogenesis due to hyperproduction of VEGF (p=0.001, p=0.0001 and p=0.001, respectively) in the blood serum. Elevated serum VEGF values in patients confirmed the presence of endothelial dysfunction in liver pathology. The study of the single nucleotide polymorphism of the VEGFA gene (G634C) showed a higher incidence of recessive allele C in patients with steatosis and cirrhosis in 54.81% (p=0.01) and 48.9% (p=0.04) of cases than in the control group -37.69%, which suggested the presence of an association of the carrier of allele C of this polymorphism in the form of genotypes CC or GC with a risk of developing steatosis and cirrhosis of the liver. Conclusion. Determination of the genetic marker VEGFA in the region -634G/C allows us to assess the increased risk of developing chronic liver diseases when exposed to various etiological factors.

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Role of vascular endothelial growth factor in the pathogenesis of hepatic steatosis and dyslipidemia

Cited by 3 publications

References 0 publications

Metabolic fatty liver disease as a risk factor for early renal dysfunction in women of reproductive age

Metabolic fatty liver disease as a risk factor for early renal dysfunction in women of reproductive age

Ultrasound Score of Liver Steatosis Severity in the Diagnosis of Peripheral Arterial Atherosclerosis in Patients with Nonalcoholic Fatty Liver Disease

The importance of vascular endothelial growth factor and polymorphism of the VEGF a gene (g634c) in the development of steatosis, fibrosis and cirrhosis of the liver patients in the city of Perm

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