Role of Vasopressin in the Mitotic Response of Rat Bone Marrow Cells to Haemorrhage

Hunt, Nicholas H.; Perris, A. D.; Sandford, P. A.

doi:10.1677/joe.0.0720005

Cited by 48 publications

(16 citation statements)

References 23 publications

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“…It has been shown that VP stimulates mitogenesis in a number of systems, including mouse Swiss 3T3 cells (Rozengurt et al, 1979), rat bone marrow cells following hemorrhage (Hunt et al, 1977), rat liver cells (Russell & Bucher, 1983), mesangial cell (Ghosh et al, 2001), human osteoblastlike cells (Lagumdzija et al, 2004) and the murine corticotroph tumor cell line, AtT20 (van Wijk et al, 1995). VP has also been shown to increase the number of cells incorporating BrdU in primary cultures of rat anterior pituitary cells (McNicol et al, 1990).…”

Section: Alternative Actions Of Vp In the Pituitary On Mitogenesismentioning

confidence: 99%

The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress

Aguilera

Subburaju

Young

et al. 2008

Progress in Brain Research

132

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Vasopressin (VP) secreted from parvocellular neurons of the hypothalamic paraventricular nucleus (PVN) stimulates pituitary ACTH secretion, through interaction with receptors of the V1b subtype (V1bR) in the pituitary corticotroph, mainly by potentiating the stimulatory effects of corticotrophin releasing hormone (CRH). Chronic stress paradigms associated with corticotroph hyperresponsiveness lead to preferential expression of hypothalamic VP over CRH and upregulation of pituitary V1bR, suggesting that VP has a primary role during adaptation of the hypothalamic pituitary adrenal (HPA) axis to long-term stimulation. However, studies using pharmacological of genetic ablation of V1b receptors have shown that VP is required for full ACTH responses to some stressors, but not for the sensitization of ACTH responses to a novel stress observed during chronic stress. Studies using minipump infusion of a peptide V1 antagonist in long-term adrenalectomized rats have revealed that VP mediates proliferative responses in the pituitary. Nevertheless, only a minor proportion of cells undergoing mitogenesis co-express markers for differentiated corticotrophs or precursors, suggesting that new corticotrophs are recruited from yet undifferentiated cells. The overall evidence supports a limited role of VP regulating acute ACTH responses to some acute stressors and points to cell proliferation and pituitary remodeling as alternative roles for the marked increases in parvocellular vasopressinergic activity during prolonged activation of the HPA axis.

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Section: Alternative Actions Of Vp In the Pituitary On Mitogenesismentioning

confidence: 99%

The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress

Aguilera

Subburaju

Young

et al. 2008

Progress in Brain Research

132

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“…The neurohormone vasopressin and the tetradecapeptide bombesin (1) are also potent mitogens. The former stimulates DNA synthesis in chondrocytes (26), bone marrow cells (18), and Swiss 3T3 mouse fibroblasts (34). The latter, which stimulates hormone secretion (37) and smooth muscle contraction and affects temperature control and behavior in mammals (14,38), shows potent mitogenic activity on Swiss 3T3 fibroblasts (35), in which high-affinity receptors for peptides of the bombesin family were recently demonstrated (45).…”

mentioning

confidence: 99%

Receptor for bombesin with associated tyrosine kinase activity.

Cirillo¹,

Gaudino²,

Naldini³

et al. 1986

Mol. Cell. Biol.

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The neuropeptide bombesin is known for its potent mitogenic activity on murine 3T3 fibroblasts and other cells. Recently it has been implicated in the pathogenesis of small cell lung carcinoma, in which it acts through an autocrine loop of growth stimulation. Phosphotyrosine (P-Tyr) antibodies have been Many recent reports on proliferative growth factors provide evidence that peptides already known for their hormonal or neurotransmitter nature can act as mitogens. Two mammalian members of the tachykinin family, substance P and substance K, which are present in sensory neurons, specifically stimulate DNA synthesis in cultured arterial smooth muscle cells and human skin fibroblasts (32). The neurohormone vasopressin and the tetradecapeptide bombesin (1) are also potent mitogens. The former stimulates DNA synthesis in chondrocytes (26), bone marrow cells (18), and Swiss 3T3 mouse fibroblasts (34). The latter, which stimulates hormone secretion (37) and smooth muscle contraction and affects temperature control and behavior in mammals (14, 38), shows potent mitogenic activity on Swiss 3T3 fibroblasts (35), in which high-affinity receptors for peptides of the bombesin family were recently demonstrated (45).Bombesin and bombesinlike peptides have been detected in various normal mammalian tissues (28,40,42), together with specific cell surface receptors (21, 27). These peptides have also been shown to behave as growth factors for normal human bronchial epithelial cells (44) and for human small cell lung carcinoma, in which they appear to act in an autocrine circuit stimulating growth (6). Furthermore, high levels of bombesinlike immunoreactivity were reported in rat mammary (13) human lung (10, 29), and human thyroid (25) tumors. The broad tissue specificity of this peptide and its mitogenic activity on different cell types suggest a role for bombesin in growth control of both normal and transformed cells. oncogenes (16,17). Bombesin, like the tachykinins and vasopressin, stimulates polyphosphoinositide breakdown (2). It has also recently been shown that bombesin induces rapid and transient expression of c-fos and c-myc protooncogenes (A. P. Palumbo, P. Rossino, and P. M. Comoglio, Exp. Cell Res., in press).To assess whether the mitogenic effect of bombesin involves a receptor-linked protein tyrosine kinase activity, we used purified antibodies capable of recognizing phosphotyrosine (P-Tyr) residues in proteins (5, 31, 46) (P-Tyr antibodies). These antibodies have been used to detect tyrosine protein kinases associated with growth factor receptors through identification of the autophosphorylated receptor and its cellular substrates in mitogen-stimulated cells (7a, 9, 11, 12, 43). The present investigation demonstrates that bombesin specifically stimulates the phosphorylation on tyrosine of a membrane protein of Mr 115,000 (p115). Immunoprecipitates of this protein, made with P-Tyr antibodies from bombesin-stimulated cells, displayed a bombesindependent tyrosine kinase activity and bound labeled bombesin in a specific...

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“…Both vasopressin and oxytocin have replaced interleukin-2 (the T-cell growth factor) for y-interferon production by Lyt 2+ mouse lymphocytes (17). Although the neurohypophyseal peptides are not directly mitogenic for peripheral lymphocytes [(17) and personal observationsl, vasopressin stimulates DNA synthesis in bone marrow cells (18). Recently the role of several neuropeptides in the control of cell proliferation has been suggested (19).…”

mentioning

confidence: 99%

The Neuroendocrine Thymus: Coexistence of Oxytocin and Neurophysin in the Human Thymus

Geenen

Legros

Franchimont

et al. 1986

Science

187

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Immunoreactive oxytocin and neurophysin were identified and measured by radioimmunoassay in human thymus extracts. Serial dilutions of extracts paralleled the appropriate standard curves. Thymus-extracted oxytocin and neurophysin eluted in the same positions as reference preparations on Sephadex G-75. Authenticity of oxytocin was confirmed by biological assay and high-performance liquid chromatography analysis. In most instances, thymus contents of oxytocin and neurophysin were far greater than those expected from known circulating concentrations and declined with increasing age. The molar ratio of oxytocin to neurophysin in thymus was similar to that found in the hypothalamo-neurohypophyseal system, which strongly suggested with the other data a local synthesis of oxytocin. These findings indicate the presence of neurohypophyseal peptides in the human thymus and further support the concept of a neuroendocrine function integrated in an immune structure.

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Role of Vasopressin in the Mitotic Response of Rat Bone Marrow Cells to Haemorrhage

Cited by 48 publications

References 23 publications

The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress

The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress

Receptor for bombesin with associated tyrosine kinase activity.

The Neuroendocrine Thymus: Coexistence of Oxytocin and Neurophysin in the Human Thymus

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