Role of VEGF in Kidney Development, Microvascular Maintenance and Pathophysiology of Renal Disease

Kim, Byung Soo; Goligorsky, Michael S.

doi:10.3904/kjim.2003.18.2.65

Cited by 26 publications

(3 citation statements)

References 110 publications

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“…The final effect of unfavorable processes is progression to renal fibrosis. Due to advancing fibrotic changes and loss of endothelial cells, podocytes, and tubular epithelial cells, the production of VEGF is decreased and the process progresses to the advanced stages of chronic kidney disease [15].…”

Section: Discussionmentioning

confidence: 99%

Disturbances in angiogenesis and vascular maturation in the skin are associated with diabetic kidney disease in type 1 diabetes

Adamska

Piłaciński

Zozulińska‐Ziółkiewicz

et al. 2019

Clinical Diabetology

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Introduction. The skin, as one of the most accessible tissues, is frequently used for investigations of microcirculation and angiogenesis. The aim of this study was to assess the relationship between the dermal microvessel density (MVD) and maturity and the presence of diabetic kidney disease (DKD) in adults with type 1 diabetes (T1D). Skin as the most accessible organ served as a model for the study of angiogenesis. Materials and methods. 148 consecutive T1D patients (87 men), median age of 41 [interquartile range (IQR): 31-49] years and diabetes duration of 21 (17-30) years, participated in the study. The patients were under the care of the

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Section: Discussionmentioning

confidence: 99%

Disturbances in angiogenesis and vascular maturation in the skin are associated with diabetic kidney disease in type 1 diabetes

Adamska

Piłaciński

Zozulińska‐Ziółkiewicz

et al. 2019

Clinical Diabetology

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“…VEGF is said to be upregulated in early stages of renal damage including acute glomerulonephritis and early diabetic nephropathy. Exogenous VEGF appears to enhance this process and VEGF has been shown to induce tubular proliferation in metanephric organ culture experiments and has a tubule protective effect [11].…”

Section: Discussionmentioning

confidence: 99%

Expression of vascular endothelial growth factor (VEGF) in IgA nephropathy

Gomathi

Adayalam

2019

Trop J Pathol Microbiol

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Background: Vascular endothelial growth factor (VEGF) is an important mediator involved in maintaining normal kidney function. Loss of normal or controlled secretion of VEGF following damage to the visceral epithelial cells could lead to alterations in endothelial cell function.This study was carried out to evaluate expression of VEGF in IgA nephropathy in order to look for potential diagnostic markers and predictive markers for progression towards CKD. Methods: This retrospective record based cross sectional study was carried out on a total of 16 whole renal cell biopsy specimens. Following the diagnosis of IgA nephropathy, immunohistochemical techniques were used to evaluate the VEGF expression. The expression of VEGF was graded and evaluated specific for the type of IgA nephropathy. Results: VEGF expression was positive in 6 specimens (37.5%). The type of glomerular involvement showing VEGF positivity was mesangial proliferative glomerulonephritis, minimal change disease (12.5%), post infectious glomerulonephritis (6.25%) and focal-segmental glomerulosclerosis (6.25%). All the specimens which showed VEGF positivity were showing well-defined areas with positive cells (25-50%). Conclusion: Considering the high magnitude of VEGF expression, the present study has potentiated the need for evaluating the statistical significance in attributing VEGF to IgA nephropathy in a larger volume of specimens.

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“…Furthermore, the decellularized scaffold retained 64% of VEGH compared to the native kidney. This growth factor is crucial for kidney bioengineering as it plays a role in angiogenesis and renal podocyte development 24 .…”

Section: Proteomic Analysis Of the Extracellular Matrixmentioning

confidence: 99%

Evaluating different methods for kidney recellularization

Luque-Badillo,

Monjaras-Avila,

Adomat

et al. 2024

Preprint

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This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation is the best option, but there aren't enough organs available. The researchers used tissue engineering to evaluate the possibility for creating kidneys for transplantation. They used pig kidneys, removing cells through a process called decellularization while preserving the organ's microarchitecture. The researchers then perfused pig kidney cells and human red blood cells to the empty kidney structure to recreate it. The methodologies used, showed promising results, suggesting a hopeful method to address the organ shortage. This proof-of-concept lays the foundation for potentially applying this technology to human kidneys, which could significantly improve outcomes for ESRD patients by providing more transplantable organs.

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Role of VEGF in Kidney Development, Microvascular Maintenance and Pathophysiology of Renal Disease

Cited by 26 publications

References 110 publications

Disturbances in angiogenesis and vascular maturation in the skin are associated with diabetic kidney disease in type 1 diabetes

Disturbances in angiogenesis and vascular maturation in the skin are associated with diabetic kidney disease in type 1 diabetes

Expression of vascular endothelial growth factor (VEGF) in IgA nephropathy

Evaluating different methods for kidney recellularization

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