Role of vinca alkaloids and their derivatives in cancer therapy

Abstract

Vinca alkaloids and its derivatives like Vincristine, Vinblastine etc. isolated from Catharanthus roseus plants are widely used in the treatment of various types of cancers. Mode of action of Vinca alkaloids (vinblastine, vincristine, vinorelbine) is microtubule-stabilizing agents (MTAs) i.e., arrest the cell cycle via disrupting microtubule dynamics. Vincristine major side effect is neurotoxicity. Hoverer, Vincristine induce neuropathy in mice or rat, used as animal model to study effect of drugs or plants by various authors also reported in review literature. Vinca alkaloids and its derivatives were widely used drugs in combination regimens with cyclophosphamide, doxorubicin, procarbazine, Methotrexate and dacarbazine etc. in various types of cancer. In this review, we also discussed major structure modifications position of chemically synthesized vincristine and vinblastine derivatives required for potential anticancer activities. Anticancer mechanism and some major patents on vinca alkaloids derivatives also reported in this review article. The study of Vinca alkaloids and its derivatives a class of an antimitotic compounds, found essential role in anticancer therapies.

Biosynthesis of anticancer phytochemical compounds and their chemistry

“…(Milano et al, 2022). Vinblastine and vinorelbine exhibit lower neurotoxicity than vincristine (Verma et al, 2022).…”

Cytotoxic, Antiproliferative and Pro-apoptotic Activities of Spirobisindole Alkaloids from the Philippine Medicinal Plant Voacanga globosa

“…Generally, alkaloids can be further classified into indole, benzylisoquinoline, isoquinoline, purine, pyrrole, and quinolone alkaloids based on associated structural moieties (Lu et al 2012;Rosales et al 2020). Taxol and Vinca alkaloids, including their derivatives, are well-known examples of alkaloids that are now clinically utilized drugs in cancer therapy (Suffness & Wall 2021;Verma et al 2022;Cech & Oberlies 2023). Recently, biologically active spirobisindole alkaloids globospiramine (1), deoxyvobtusine (2), and deoxyobtusine lactone (3) from the medicinal plant Voacanga globosa have been isolated.…”

Formulating co-loaded nanoliposomes with gallic acid and quercetin for enhanced cancer therapy

“…Protocols that are based on combined therapeutic agents have less substantial adverse effects than conventional treatments based on high doses of a single chemotherapeutic agent [ 3 ]. Since the earliest known anticancer medication originated from natural resources such as Vinca alkaloids, which were extracted from the Catharanthus roseus plant, increasing attention was directed toward investigating the cytotoxicity of variable phytomedicines [ 4 ]. Favorable pharmacokinetics and wide therapeutic indices motivate the inspection of herbal medicines for their anticancer characteristics [ 5 ].…”