Role of viral infection in sudden hearing loss

Chen, Xin; Fu, Yaoyao; Zhang, Tianyu

doi:10.1177/0300060519847860

Cited by 96 publications

(81 citation statements)

References 51 publications

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“…Three possible pathophysiological mechanisms for sudden hearing loss are classically described: a microcirculatory disorder, inapparent viral infection, and a localized immune process [ 11 ]. Our patient had an autoimmune disease and presented with a severe viral infection with probable mechanisms of aggression to the microcirculation.…”

Section: Discussionmentioning

confidence: 99%

A 67-Year-Old Woman with Sudden Hearing Loss Associated with SARS-CoV-2 Infection

Lamounier¹,

Gonçalves²,

Ramos³

et al. 2020

Am J Case Rep

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Patient: Female, 67-year-old Final Diagnosis: SARS-CoV-2 Symptoms: Cough • fever • hearing Loss Medication: — Clinical Procedure: Intensive Care Unit (ICU) Specialty: Otolaryngology Objective: Unusual clinical course Background: Few reports have described the association between coronavirus disease 2019 (COVID-19) and sudden hearing loss. The precise pathophysiological mechanism causing this symptom is unknown. This report describes a case of sudden hearing loss in a patient with COVID-19 pneumonia due to SARS-CoV-2 infection. Case Report: A 67-year-old woman with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as confirmed by reverse transcription-polymerase chain reaction (RT-PCR) testing from nasopharyngeal and oropharyngeal swabs, was examined. She experienced sudden hearing loss in her right ear and disabling tinnitus. She underwent combined corticosteroid therapy (oral and intratympanic), resulting in an isolated improvement of 250 kHz in the right ear (from 60 dB, the threshold became 15 dB) and of 4, 6, and 8 kHz in the left ear (from 35 dB, 20 dB, and 35 dB, the thresholds became 15 dB, 5 dB and 20 dB, respectively). Conclusions: Although rare, hearing loss appears to be a possible sequela to SARS-CoV-2 infection and deserves attention because it is a medical emergency requiring immediate clinical treatment. Additional studies are needed to assess the pathophysiological mechanisms involved in and the long-term characteristics of this type of hearing loss.

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Section: Discussionmentioning

confidence: 99%

A 67-Year-Old Woman with Sudden Hearing Loss Associated with SARS-CoV-2 Infection

Lamounier¹,

Gonçalves²,

Ramos³

et al. 2020

Am J Case Rep

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show abstract

“…There were not yet reports of earache, loss of hearing, facial paralysis, or dizziness during the survey design. We included these symptoms, because they can accompany other well-studied viral diseases [ 22 – 24 ].…”

Section: Methodsmentioning

confidence: 99%

Symptomatology of COVID-19 from the otorhinolaryngology perspective: a survey of 223 SARS-CoV-2 RNA-positive patients

Salepçi

Türk

Ozcan

et al. 2020

Eur Arch Otorhinolaryngol

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Purpose To determine prevalence, severity, duration, and time from onset to diagnosis of general and Otorhinolaryngologic symptoms related to COVID-19 in whole disease spectrum: from mild to critical patients. Methods All adult patients with positive SARS-CoV-2 RNA found in nasopharyngeal and oropharyngeal swabs between March 10 and April 21, 2020 were surveyed by the authors for new onset symptoms during disease course. Demographic features, general symptoms, and Otorhinolaryngological symptoms were evaluated and compared by disease severity. Results Of 223 included patients, 18.4% had mild, 61.4%; moderate, 14.3%; severe, and 5.8%; critical disease. Median age was 51 (range 20-93), 113 (50.7%) were male and 110 (49.3%) were female. The most common general symptoms were fatigue, cough, and fever with respective frequencies of 71.3%, 54.3%, and 50.7%. The most common Otorhinolaryngologic symptoms were taste loss, smell loss, and sore throat with respective frequencies of 34.5%, 31.8%, and 26%. Fatigue, fever, and dyspnea were more common in severe-critical patients compared to mild-moderate patients (p = 0.029, p = 0.016, and p < 0.001, respectively). Only smell loss was more common in mild-moderate group (p = 0.003). Prevalence of other symptoms did not differ between groups. Symptom durations and onset time to diagnosis varied. Conclusion When compared to the previous studies, while general symptoms were less common, Otorhinolaryngologic symptoms were more common in our study population. Considering high infection risks, Otorhinolaryngologists should be aware of COVID-19 patients presenting with Otorhinolaryngologic complaints.

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“…18 The virus also invades the cochlear nerve, causing neuritis, and soft tissues of the cochlea, causing cochleitis. 19 SARS-CoV-2 infection has now been identified in patients with SSNHL who have clinically relevant reductions in highfrequency pure-tone thresholds and transiently evoked otoacoustic emission amplitudes (►Fig. 1).…”

Section: Sars-cov-2 Infection and Sudden Sensorineural Hearing Lossmentioning

confidence: 99%

A Liaison between Sudden Sensorineural Hearing Loss and SARS-CoV-2 Infection

2020

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Role of viral infection in sudden hearing loss

Cited by 96 publications

References 51 publications

A 67-Year-Old Woman with Sudden Hearing Loss Associated with SARS-CoV-2 Infection

A 67-Year-Old Woman with Sudden Hearing Loss Associated with SARS-CoV-2 Infection

Symptomatology of COVID-19 from the otorhinolaryngology perspective: a survey of 223 SARS-CoV-2 RNA-positive patients

A Liaison between Sudden Sensorineural Hearing Loss and SARS-CoV-2 Infection

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