Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.

Braciale, T. J.; Yap, K. L.

doi:10.1084/jem.147.4.1236

Cited by 113 publications

(69 citation statements)

References 35 publications

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“…It has also been demonstrated that active infection is not required for the induction of a CTL response to Sendai virus (25). However, sensitization of uninfected targets does not occur with UV-inactivated influenza virus (26), and other investigators suggested that synthesis of early viral proteins is needed for lysis of vaccinia-or ectromelia-infected targets (27,28). Thus, it appears that, in some systems, virus that is passively adsorbed to the cell surface is sufficient for cell lysis by sensitized CTLs whereas, in others, intracellular synthesis of viral proteins may be required.…”

Section: Resultsmentioning

confidence: 99%

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Finberg¹,

Weiner²,

Fields³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

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Section: Resultsmentioning

confidence: 99%

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Finberg¹,

Weiner²,

Fields³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

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“…of BioQuest, Oxnard, Calif.) containing 15 ml of medium (22). The responder to stimulator cell ratio was 10:1.…”

Section: Gtntral Male Balb/c (H-2d) and Cba/h (H-mentioning

confidence: 99%

“…Viruses were assessed for serologic crossreactivity by the microtitration hemagglutination,inhibition test (22). Four HAU of a given virus in a volume of 0.025 ml PBS were added to serial twofold dilutions of each sera in a final volume of 0.025 ml in PBS.…”

Section: Gtntral Male Balb/c (H-2d) and Cba/h (H-mentioning

confidence: 99%

Specificity of cytotoxicity T cells directed to influenza virus hemagglutinin.

Braciale¹

1979

The Journal of Experimental Medicine

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Because the initial realization that T cells comprised a discrete lymphocyte class, there has been a great deal of experimental work directed toward an analysis of the nature of the antigen receptor on T cells and, concomitantly, toward an assessment of the comparative specificity of T and B cells. Perhaps a major advance in understanding the molecular nature of the antigen receptor on T cells has come from studies demonstrating the expression, on the surface of specific T cells, of idiotypie determinants (immunoglobulin heavy chain variable region gene products [Vn]) 1 which are shared with the corresponding antibody (1-3). Although from such observations it might be anticipated that T cells and antibody would have comparable degrees of specificity for antigen, analyses of T-cell specificity have not necessarily fulfilled this expectation (reviewed in reference 4).A major limitation in many analyses of T-cell specificity has been the need to rely on ancillary T-cell activities, i.e., the capacity of T cells to help or suppress humoral responses or exhibit delayed-type hypersensitivity manifestations in order to assess Tcell recognition of antigen. This limitation would appear to be less severe in the case ofcytotoxic T lymphocyte (CTL) responses as antigen recognition by CTLs is directly measured by their capacity to lyse target cells expressing the appropriate antigen (5). Thus an analysis of the fine specificity of CTL recognition could provide useful information on the comparative specificities of T and B cells.Studies on the CTL response to conventional (i.e., non major histocompatibility complex [MHC] encoded) antigen have already yielded some information with regard to CTL specificity. For example, virus-specific CTLs readily distinguish target cells infected with unrelated viruses (6). Furthermore, more recent evidence along these lines suggests that distinct viral antigens are specifically recognized by CTLs (7-1 1). Perhaps more detailed information on CTL specificity has come from the analysis of the CTL response to hapten-modified cells (12)(13)(14)(15). Overall, these studies have demonstrated a high degree of specificity in CTL recognition of hapten-modified cell surfaces; however, it is not clear from these studies whether hapten per se is exclusively

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“…On transfer, virus-specific Tc cells afford protection against lethal influenza virus infection in mice (3,4) by clearing virus from the lungs (5,6). Any vaccine strategy to control influenza virus infection should therefore be designed to induce a long-lasting, crossreactive Tc memory population to protect against any new variants of A strain influenza viruses arising from either antigenic drift or shift.…”

Section: Introductionmentioning

confidence: 99%

Gamma‐irradiated influenza A virus can prime for a cross‐reactive and cross‐protective immune response against influenza A viruses

1988

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Summary A-strain influenza virus A/JAP (H2N2) was tested for its ability to induce cytotoxic T cells (Tc) after being rendered non-infectious by either UV or gamma irradiation. Gamma-irradiated virus proved to be more efficient than U V-inactivated virus in priming for a memory Tc cell response or in boosting memory spleen cells//I vitro. Most importantly, y-inactivated, but not U V-inactivated, A/JAP immunized animals survived lethal challenge with heterologous (A/PC(H3N2), A/WSN(HIN1)) virus as effectively as mice primed with infectious virus.

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Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.

Cited by 113 publications

References 35 publications

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.

Specificity of cytotoxicity T cells directed to influenza virus hemagglutinin.

Gamma‐irradiated influenza A virus can prime for a cross‐reactive and cross‐protective immune response against influenza A viruses

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