Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review

Abdi, Fatemeh; Amjadi, Marjan Akhavan; Zaheri, Farzaneh; Rahnemaei, Fatemeh Alsadat

doi:10.5468/ogs.20205

Cited by 34 publications

(36 citation statements)

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“…There are several reports indicating an inverse relationship between vitamin D (Vit D) status and risk of depressive symptoms [ 7 , 8 ], fibromyalgia [ 9 ], and uterine leiomyomas [ 10 ]. Additionally, low levels of Vit D and calcium can promote dysmenorrhea pain by elevating prostaglandin genesis or decreasing intestinal calcium absorption [ 11 ]. Moreover, a high Vit D intake may mitigate the risk of PMS, by effects on sex steroid hormone and neurotransmitter activities [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Arabnezhad

Mohammadifard

Rahmani

et al. 2022

BMC Complement Med Ther

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Background Vitamin D has an established role in female reproduction. There is also evidence for an association between vitamin D levels and menstrual problems such as premenstrual syndrome (PMS) and dysmenorrhea. Curcumin, is a bioactive polyphenol constituent of turmeric, that can potentially interact with vitamin D receptors and its molecular targets. This study evaluated the effects of curcumin on vitamin D levels in young women with PMS and dysmenorrhea. Methods In this randomized, triple-blind, placebo-controlled trial, women with PMS and dysmenorrhea were divided randomly into experimental and control groups to receive one capsule (500 mg of curcuminoid+ 5 mg piperine, or placebo) daily, from approximately 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Serum vitamin D levels, renal function, and liver enzymes were also measured before and after intervention. Results A total of 76 subjects (38 in each group) were recruited into the trial. Curcumin significantly increased the median (IQR) serum levels of vitamin D [from 12.8 ng/ml (7.0–24.6) to 16.2 ng/ml (6.4–28.8); P = 0.045], compared with placebo [from 18.6 ng/ml (2.2–26.8) to 21.3 ng/ml (5.2–27.1); P = 0.17]. Serum levels of aspartate aminotransferase and direct bilirubin were reduced by the end of trial in the curcumin group (p < 0.05), but did not change significantly in the control group (p > 0.05). Finally, no significant differences in levels of fasting blood glucose were detected between curcumin and placebo groups. Conclusion Curcumin supplementation in women with PMS and dysmenorrhea led to a significant improvement of vitamin D, liver function enzyme test, but did not affect blood glucose. Trial registration The trial was registered on Iranian Registry of Clinical Trials registry (Trial ID: IRCT20191112045424N1 on 23 January 2020; available at https://www.irct.ir).

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Section: Introductionmentioning

confidence: 99%

Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Arabnezhad

Mohammadifard

Rahmani

et al. 2022

BMC Complement Med Ther

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“…A systematic review reported an inverse relation between serum vitamin D/calcium and severity of PD, and reduced severity of PD after vitamin D/calcium intake [12].…”

Section: Discussionmentioning

confidence: 99%

“…Low serum vitamin D was reported during the luteal phase of the menstrual cycle [11], and a systematic review reported vitamin D de ciency in severe PD [12].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Donayeva

Amanzholkyzy

Nurgaliyeva

et al. 2023

Preprint

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Background: The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation. Objective: This study aimed to detect the relation between serum 25(OH)D and primary dysmenorrhea. Methods: Two hundred and five (205) adolescents complaining of primary dysmenorrhea (study group) were compared with matched controls (210 controls), after informed consent following the Helsinki Declaration. After thorough evaluation, and pelvic ultrasound examination, blood samples were collected from the studied adolescents for measuring the serum 25(OH)D and for vitamin D receptor TaqI (rs731236) genotyping. Collected data were analyzed using the Pearson`s correlation to detect the relation between serum 25(OH)D and primary dysmenorrhea (primary outcome). The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with TaqI (rs731236) polymorphism. Results: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17 ± 7.36 versus 17.65 ± 6.36 ng/ml, respectively), (P=0.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D, and visual analogue scale of dysmenorrhea (r=-0.9003, P<0.0001). The studied-dysmenorrhea cases with T/t and t/t genotypes had significantly lower serum 25(OH)D (16.7 ± 8.05 and 14.4 ± 4.1 ng/ml, respectively) compared to controls (18.97 ± 6.7 and 21.4 ± 2.45 ng/ml, respectively), (P=0.02 and 0.004, respectively). The odds of primary dysmenorrhea were significantly higher in T/t and t/t genotypes (OR 1367.2, P<0.0001, and 106.2, P=0.001, respectively). Conclusion: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with T/t and t/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The odds of primary dysmenorrhea were significantly higher in T/t and t/t TaqI genotypes.

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“…It could be assumed that vitamin D and parathyroid hormone play a role in the intensity of systemic physical and mental symptoms of premenstrual syndrome [ 40 ]. Moreover, taking calcium and vitamin D supplements will improve the physical and psychological symptoms of premenstrual syndrome and primary dysmenorrhea [ 16 , 17 ]. We did not measure the calcium level in this study, and its role in the development of symptoms and responses to vitamin D supplementation in patients with primary dysmenorrhea warrants further investigations.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that the serum levels of vitamin D reduce in the luteal phase of the menstrual cycle [ 16 ]. The role of vitamin D deficiency in inducing or exacerbating the symptoms of primary dysmenorrhea has been addressed by some studies [ 17 ]. Vitamin D metabolites (e.g., 25[OH]D and 1,25[OH]2D) reduce the levels of inflammatory cytokines and associated contractile factors (prostaglandin) in the endometrium and incapacitate its biological activity by affecting its receptors in the endometrium [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial

et al. 2021

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Objective: Primary dysmenorrhea is believed to be common and associated with reduced quality of life among menstruating women. Recent studies have shown a possible association between vitamin D deficiency and the severity of primary dysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemic symptoms in patients with primary dysmenorrhea.Methods: This double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years with primary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IU of vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes were pain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), and severity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12).Results: Compared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity (-1.0 and -1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (-1.0 day at weeks 4 and 8, P<0.001), the number of consumed pain-relief medications (-1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (-1.0 score at weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes. Conclusion:Vitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemic symptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.

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Role of vitamin D and calcium in the relief of primary dysmenorrhea: a systematic review

Cited by 34 publications

References 50 publications

Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary dysmenorrhea

Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial

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