Role of water quality assessments in hospital infection control: Experience from a new oncology center in eastern India

Bhalchandra, Ramkrishna; Chandy, Mammen; Ramanan, Venkata Raman; Mahajan, Aseem; Soundaranayagam, Jeeva Ratnam; Garai, Subrata; Bhattacharya, Sanjay

doi:10.4103/0377-4929.138745

Cited by 10 publications

(3 citation statements)

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“…Maintaining a good quality of water supply in hospital and community settings (for example through adequate and appropriate levels of chlorination) and checking the water quality microbiologically by sensitive techniques [155]. …”

Section: Prevention Strategiesmentioning

confidence: 99%

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Exner

Bhattacharya

Christiansen

et al. 2017

GMS Hygiene and Infection Control; 12:Doc05

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191

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Section: Prevention Strategiesmentioning

confidence: 99%

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Exner

Bhattacharya

Christiansen

et al. 2017

GMS Hygiene and Infection Control; 12:Doc05

Self Cite

191

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“…Patient rooms are fitted with Pall 0.2-μm water filters in the shower heads and faucets. 6,7 Regular audits for hand hygiene compliance, air and water quality, and sterilization/disinfection are done to ensure that standards are met. Despite these strict measures, our center has seen a considerable number of MDRO bloodstream infections in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…The bone marrow transplant unit is High Efficiency Particle Arrester filtered and positive differential pressure of 2.5 Pascal higher than the ante‐room/corridor is maintained. Patient rooms are fitted with Pall 0.2‐μm water filters in the shower heads and faucets 6,7 . Regular audits for hand hygiene compliance, air and water quality, and sterilization/disinfection are done to ensure that standards are met.…”

Section: Introductionmentioning

confidence: 99%

Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India

Ghosh

Bhattacharya

Goel

et al. 2023

Transplant Infectious Dis

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BackgroundInfections by multidrug‐resistant organisms (MDRO) are a major hurdle in hematopoietic stem‐cell transplants (HSCTs). Conditioning regimens lead to mucosal barrier injury, which in‐turn leads to transmigration of gut bacteria and sepsis. Pre‐transplant stool and throat surveillance cultures can guide empirical antibiotic policy during the neutropenic period. In this paper, we document colonization with MDRO in pre‐transplant surveillance cultures and the correlation with bloodstream infections in HSCT patients and analyze transplant outcomes with respect to these infections.MethodsA single‐center, retrospective study on HSCT was performed between January 2021 and December 2021. The incidence of bacterial infections, percentage of MDROs, correlation with pre‐transplant stool/throat surveillance cultures, and their impact on overall 100‐day and post‐100‐day to 6‐month post‐transplant survival were analyzed.ResultsSixty‐four patients were included in the study. Pre‐transplant stool surveillance cultures were positive for MDRO in 85.9% of patients. Almost half (48.5%) of the isolates were positive for carbapenemase‐producing genes (mainly New Delhi metallo‐beta‐lactamase‐1 [NDM‐1] and oxacillinase‐48 [OXA‐48]). Eighteen patients (18/64, 28%) had a positive blood culture for MDRO in the peri‐engraftment neutropenic period. Correlation between surveillance and blood cultures was seen in 61% (11/18) of patients. All‐cause mortality was 14.1% (9/64) and 25% (16/64) in patients at 100 days and 6 months post‐HSCT, respectively. The 100‐day and post‐100‐day all‐cause mortality rates were higher in patients with Gram‐negative MDRO bloodstream infections (p < .012 and <.008, respectively).ConclusionMDRO infections can adversely affect HSCT outcomes. Pre‐transplant stool and throat surveillance cultures may guide empirical antibiotic policy and lead to favorable transplant outcomes. image

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Infections in Hematopoietic Stem Cell Transplantation (HSCT) Patients

George

Bhattacharya

2021

Organ and Tissue Transplantation

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Infections in patients with hematopoietic stem cell transplantation (HSCT) continue to remain a formidable challenge for transplanters, caregivers, and patients. The problem has been exacerbated in recent years due to the emergence of multidrug-resistant (MDR) pathogens especially among bacteria. Despite the many obvious developments in diagnostic technology and infection control practices, morbidity, mortality, and cost of care remains high due to infections in the setting of HSCT. Molecular methods in diagnosis of pathogens, improvement in infection prevention and control practices, and better use of antimicrobial therapy and prophylaxis based on pharmacokinetic-pharmacodynamic considerations and immunizations have improved outcome among HSCT patients, but a lot more remains to be achieved. Some unanswered queries persist, for example, the value of surveillance microbiology-based empirical antimicrobial therapy; the absence of decolonization therapy for MDR Gram-negative bacilli; and the role of host microbiome in influencing predilection, course, or outcome in infections. The current chapter provides a summary of the existing literature and attempts to elicit the standard of practice in the management of patients with regard to infections in the HSCT scenario.

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Role of water quality assessments in hospital infection control: Experience from a new oncology center in eastern India

Cited by 10 publications

References 0 publications

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India

Infections in Hematopoietic Stem Cell Transplantation (HSCT) Patients

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