Role of zinc in regulating the testicular function Part 3. Histopathological changes induced by dietary zinc deficiency in testes of male albino rats

Hafiez, A. A.; El‐Kirdassy, Z. H. M.; El-Malkh, N. M.; El-Zayat, Emad

doi:10.1002/food.19900340114

Cited by 19 publications

(8 citation statements)

References 8 publications

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“…It is known that dietary zinc deficiency in particular leads to hypogonadism [15]. However, it is observed that previous studies have mainly focused on the relation between the male reproductive system and zinc [1,14,15]. It was shown in a study by Om and Chun [16] that zinc deficiency caused an inhibition on LH and estrogen levels.…”

Section: Discussionmentioning

confidence: 94%

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The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

Sunar

Gormus

Baltacı

et al. 2008

Biol Trace Elem Res

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The objective of the present study is to investigate how low-dose zinc supplementation for 2 weeks in the post-menopausal period influences levels of estrogen and progesterone in the serum. The study registered 32 natural menopause patients, who were allocated to four groups with equal number of patients. Group 1, control group, which was not subjected to any procedure. Group 2, the group that was supplemented with 15 mg/day zinc sulfate for 2 weeks. Group 3, the group that was given hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) for 2 weeks. Group 4, the group that received hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) and zinc sulfate (15 mg/day) for 2 weeks. Blood samples were collected twice from each subject, once at the beginning of the study, and once at the end of the 4-week procedure to determine estrogen (E2) and progesterone levels. Variance analysis was employed in the statistical evaluation of data. Level of significance was set at p < 0.05. No significant difference was found between the estrogen and progesterone levels of groups 1 and 2. Groups 3 and 4 had higher estrogen and progesterone levels than groups 1 and 2 (p < 0.05). Estrogen and progesterone levels in groups 3 and 4 were not different. Results of the study show that low-dose zinc supplementation to post-menopausal women for 2 weeks does not have a significant effect on the concerned parameters.

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Section: Discussionmentioning

confidence: 94%

“…Zinc has a key role in the physiology of the reproductive system [14]. It is known that dietary zinc deficiency in particular leads to hypogonadism [15].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

Sunar

Gormus

Baltacı

et al. 2008

Biol Trace Elem Res

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“…The trace element zinc is speculated to play a critical role in sexual development. Zinc deficiency was found to disrupt testicular tissue [ 40 ], impair spermatogenesis [ 41 ], and reduce testosterone levels [ 42 ], while zinc supplementation improved the sexual behavior of adult male rats in a dose-dependent manner by enhancing testosterone secretion [ 43 ]. Moreover, Prasad et al [ 44 ] reported a positive correlation between cellular zinc concentration and serum testosterone level in healthy men.…”

Section: Discussionmentioning

confidence: 99%

Influence of Cyperus esculentus tubers (Tiger Nut) on male rat copulatory behavior

Allouh

Daradka

Ghaida

2015

BMC Complement Altern Med

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BackgroundCyperus esculentus tubers (tiger nut) are one of the ancient food sources known to humanity. It is traditionally used in the Middle East to stimulate sexual arousal in men. However, there has been no scientific evidence about its assumed aphrodisiac properties. This study aimed to investigate the influence of tiger nut on the copulatory behavior of sexually active male rats.MethodsTwo sets of sexually active male rats -highly active and moderately active- were identified depending on baseline sexual activity. Rats in each set were randomly divided into a control and treated groups. Highly active rats were treated with doses of 1 and 2 g/kg/d of raw tiger nut powder, while moderately active rats were treated with a dose of 2 g/kg/d. After 30 days’ treatment, copulatory behavior and serum hormonal levels were measured and compared between the groups within each experimental set. Phytochemical analyses including liquid chromatography/mass spectrometry and atomic absorption were performed to elucidate the main constituents of tiger nut that may be responsible for altering serum hormones.ResultsTiger nut stimulated sexual motivation in both highly and moderately active rats, indicated by reduced mount and intromission latencies in these rats compared to controls. Furthermore, tiger nut improved sexual performance, indicated by increased intromission frequency and ratio, in treated moderately active rats compared to controls. Serum testosterone levels increased significantly after tiger nut administration. Lastly, phytochemical analyses revealed the presence of quercetin, vitamin C, vitamin E, and mineral zinc in tiger nut.ConclusionsTiger nut has positive effects on the copulatory behavior of adult male rats.

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“…[ 41 ] Dietary Zn deficiency for 4 weeks in the albino rat has been reported to arrest the spermatogenesis process and seminiferous tubule degeneration. [ 42 ] ZDD fed male Balady rabbits for 120 days were reported to have decreasede secretory functions in epididymis as compared with control. [ 43 ] Prostate histopathology showed folded lobules and lobular damage in BPA, ZDD, and BPA + ZDD exposed animals as compared with control.…”

Section: Discussionmentioning

confidence: 99%

Zinc deficient diet increases the toxicity of bisphenol A in rat testis

Sahu

Charaya

Singla

et al. 2020

J Biochem & Molecular Tox

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Zinc (Zn) plays an important role in maintaining the process of spermatogenesis and reproductive health. Bisphenol A (BPA), an endocrine disrupting chemical is known to be a reproductive toxicant in different animal models. The present study was designed to study the effect of two of the utmost determinative factors (Zn deficient condition and influence of toxicant BPA) on germ cell growth and overall male reproductive health in the testis, epididymis, and sperm using (a) biochemical, (b) antioxidant, (c) cellular damage, (d) apoptosis, and (e) protein expression measurements. Rats were divided into Control (normal feed and water), BPA (100 mg/kg/d), zinc deficient diet (ZDD; fed with ZDD), and BPA + ZDD for 8 weeks. Body and organ weights, sperm motility and counts, and sperm head morphology were evaluated. The histology of testes, epididymides, and prostate was investigated. Testicular deoxyribonucleic acid (DNA) damage was evaluated by Halo and Comet assay, apoptosis of sperm and testes were quantified by TUNEL assay. Serum protein electrophoretic patterns and testicular protein expressions such as Nrf-2, catalase, PCNA, and Keap1 were analyzed by Western blot analysis. The results showed that BPA significantly increased the testicular, epididymal, and prostrate toxicity in dietary Zn deficient condition due to testicular hypozincemia, hypogonadism, increased cellular and DNA damage, apoptosis, as well as perturbations in protein expression.

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Role of zinc in regulating the testicular function Part 3. Histopathological changes induced by dietary zinc deficiency in testes of male albino rats

Cited by 19 publications

References 8 publications

The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

Influence of Cyperus esculentus tubers (Tiger Nut) on male rat copulatory behavior

Zinc deficient diet increases the toxicity of bisphenol A in rat testis

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