The Effect of Low Dose Zinc Supplementation to Serum Estrogen and Progesterone Levels in Post-menopausal Women

Abstract

The objective of the present study is to investigate how low-dose zinc supplementation for 2 weeks in the post-menopausal period influences levels of estrogen and progesterone in the serum. The study registered 32 natural menopause patients, who were allocated to four groups with equal number of patients. Group 1, control group, which was not subjected to any procedure. Group 2, the group that was supplemented with 15 mg/day zinc sulfate for 2 weeks. Group 3, the group that was given hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) for 2 weeks. Group 4, the group that received hormone replacement therapy (0.625 mg estrogen + 5 mg medroxyprogesterone acetate/day) and zinc sulfate (15 mg/day) for 2 weeks. Blood samples were collected twice from each subject, once at the beginning of the study, and once at the end of the 4-week procedure to determine estrogen (E2) and progesterone levels. Variance analysis was employed in the statistical evaluation of data. Level of significance was set at p < 0.05. No significant difference was found between the estrogen and progesterone levels of groups 1 and 2. Groups 3 and 4 had higher estrogen and progesterone levels than groups 1 and 2 (p < 0.05). Estrogen and progesterone levels in groups 3 and 4 were not different. Results of the study show that low-dose zinc supplementation to post-menopausal women for 2 weeks does not have a significant effect on the concerned parameters.

Effect of Administration of Zinc and Ginseng on Reproductive Performance and Level of Some Hormones of Local Ewes

“…Studies have shown that zinc deficiency in female animals increases the mortality rate of fetuses and results in low pregnancy rates, meaning that zinc deficiency affects reproductive outcomes in mice [11,12]. The study confirmed the preventive effectiveness of zinc in reducing the overall complication rate for both mother and fetus and that diets deficient in zinc are the cause of a high incidence of miscarriage [13]. As well as the role of the ginseng plant, the results of the current study showed that it has beneficial effects on the reproductive performance of local ewes.…”

Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI

“…Since progestin had little ability to reverse OHT and ICI inhibition of T47D cell growth, the progestin effect is likely related to the ERαY537S and ERαD538G mutations. Consistent with the possibility that serum progestin might influence antiestrogen resistance in women whose breast cancers express the ERαY537S and ERαD538G mutations, progesterone levels in post-menopausal women are 0.6–3 nM 59 60 61 . Moreover, breast cancer cells expressing both ERα and PR, or overexpressing PR alone, may be sensitive to very low concentrations of hormone 17 18 .…”

Zinc’s Association with the CmPn/CmP Signaling Network in Breast Cancer Tumorigenesis

“…However, relevant reports on the relationship between zinc and PRG are not without controversy. One report determined that two weeks’ supplementation with low-dose zinc had no significant effect on serum estradiol and PRG concentration in postmenopausal women [ 80 ]. Another report suggested that zinc may play an inhibitory role in the onset and maintenance of PRG production in a mouse study.…”