Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Ni, Yu‐Qing; Lin, Xiao; Zhan, Jicheng; Liu, You‐Shuo

doi:10.14336/ad.2019.0402

Cited by 47 publications

(28 citation statements)

References 139 publications

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“…LncRNAs frequently reported to regulate to cell apoptosis, angiogenesis and inflammation by has been be involved in post-stroke neuroprotection ( Liang et al, 2020 ). LncRNAs also played a pivotal role in the regulation of vascular smooth muscle cells phenotype, functions, perhaps in the development of vascular aging related heart diseases ( Ni et al, 2020 ). Regulation of cell apoptosis, angiogenesis and inflammation by lncRNAs has been frequently reported to be involved in post-stroke neuroprotection ( Qian et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients

Song

Wang²,

Hou³

et al. 2021

Front. Aging Neurosci.

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Delirium is a common serious complication that often occurs after major surgery. The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and mRNAs in patients of postoperative delirium (POD). Microarray analysis was performed on the peripheral blood samples to identify differentially expressed (DE) lncRNAs and mRNAs in 4 POD patients and 4 non-POD volunteers. DE lncRNAs and mRNAs were validated by quantitative reverse transcription PCR (RT-qPCR). Bioinformatic analyses were performed to identify the critical biological functions and signaling pathways involved in POD. A total of 1195 DE lncRNAs and 735 DE mRNAs were identified between the POD and non-POD groups. Verified by the RT-qPCR, we identified 14 DE lncRNAs that may relate to the pathogenesis of POD. These 14 DE lncRNAs play important regulatory roles in “glutamate and 5-hydroxytryptamine,” “synaptotagmin 7,” “transient receptor potential channel,” “interleukin-2 production.” There was a regulatory relationship between lncRNA ENST00000530057 and synaptotagmin (Syt) 7 mRNA. The mRNA level of PCLO was up-regulated in POD group. This study showed abundant DE lncRNAs and mRNAs in POD that might help in deciphering the disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients

Song

Wang²,

Hou³

et al. 2021

Front. Aging Neurosci.

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“…It has been shown that miRNA-233 transforms SMCs from contractile phenotype to synthetic phenotype and promotes VC (82). Other miRNAs with similar effects include miRNA-712, miRNA-714, and miRNA-762 (83). In contrast, miRNA-26a inhibits the differentiation of SMCs, and miRNAs that regulate similar effects of phenotypic transformation by targeting SMAD1 and SMAD4 include miRNA-29a/b and miRNA-125b (83,84).…”

Section: Exosomal Mirnas Regulate Vcmentioning

confidence: 99%

A narrative review of exosomes in vascular calcification

Zheng¹,

Liao²,

Xiong³

et al. 2021

Ann Transl Med

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Vascular calcification (VC) is the abnormal deposition of calcium, phosphorus, and other minerals in the vessel wall and can be commonly observed in diabetes, chronic kidney disease, and chronic inflammatory disease. It is closely associated with mortality from cardiovascular events. Traditionally, calcification is considered as a degenerative disease associated with the aging process, while increasing evidence has shown that the occurrence and development of calcification is an active biological process, which is highly regulated by multiple factors. The molecular mechanisms of VC have not yet been fully elucidated. Exosomes, as important transporters of substance transport and intercellular communication, have been shown to participate in VC. The regulation of VC by exosomes involves a number of complex biological processes, which occur through a variety of interaction mechanisms. However, the specific role and mechanism of exosomes in the process of VC are still not fully understood and require further study. This review will briefly describe the roles of exosomes in the process of VC including in the promotion of extracellular mineral deposits, induction of phenotypic conversion of vascular smooth muscle cells (VSMCs), transport of microRNA between cells, and regulation on autophagy and oxidative stress, with the aim of providing novel ideas for the clinical diagnosis and treatment of VC.

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“…Vascular aging involves phenotypic and structural changes in the vascular wall, which consist mainly of endothelial cells and vascular smooth muscle cells. Studies have found the involvement of various exosomal miRNAs and long non-coding RNAs in EC proliferation, inflammation, angiogenesis, senescence, and apoptosis [ 92 ]. For instance, cardiomyocyte-derived exosomal miR-17, miR-19, and miR-126 promoted the proliferation and migration of ECs, whereas miR-92a, miR-24, and miR-21 inhibited the processes [ 93 ].…”

Section: Other Age-related Pathologiesmentioning

confidence: 99%

“…Exosomal miR-125a and miR-106b-5p promote and inhibit angiogenesis, respectively [ 95 ]. Exosomes play a critical role in transferring signaling molecules between ECs and VSMCs and thereby modulate vascular aging [ 92 ].…”

Section: Other Age-related Pathologiesmentioning

confidence: 99%

Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies

Saheera

Potnuri²,

Krishnamurthy

2020

Cells

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Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell–cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections.

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Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Cited by 47 publications

References 139 publications

Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients

Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients

A narrative review of exosomes in vascular calcification

Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies

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