Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery

Li, Sixuan; Zhang, Hongquan; Wei, Xiaofan

doi:10.3390/life11090965

Cited by 11 publications

(8 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diversity of these DUB families highlights the complexity of deubiquitination and its potential involvement in cancer progression. Not unlike most post-translational modification, ubiquitination is also associated with many cell functions, including cell cycle progression, apoptosis, gene transcription, DNA repair, and signal transduction, which regulate cell development and differentiation and tumorigenesis ( 35 , 36 ). Therefore, components in the ubiquitin pathway have been proposed as potential targets for treatment strategies for diseases and cancer ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination

Zhang,

Wang,

Yang

et al. 2024

Transl Gastroenterol Hepatol

View full text Add to dashboard Cite

Background Transmembrane protein 43 ( TMEM43 ), a member of the TMEM subfamily, is encoded by a highly conserved gene and widely expressed in most species from bacteria to humans. In previous studies, TMEM43 has been found to play an important role in a variety of tumors. However, the role of TMEM43 in cancer remains unclear. Methods We utilized the RNA sequencing (RNA-seq) and The Cancer Genome Atlas (TGCA) databases to explore and identify genes that may play an important role in the occurrence and development of hepatocellular carcinoma (HCC), such as TMEM43 . The role of TMEM43 in HCC was explored through Cell Counting Kit-8 (CCK-8) cloning, flow cytometry, and Transwell experiments. The regulatory relationship between TMEM43 and voltage-dependent anion channel 1 ( VDAC1 ) was investigated through coimmunoprecipitation (co-IP) and western blot (WB) experiments. WB was used to study the deubiquitination effect of ubiquitin-specific protease 7 ( USP7 ) on TMEM43 . Results In this study, we utilized the RNA-seq and TGCA databases to mine data and found that TMEM43 is highly expressed in HCC. The absence of TMEM43 in cancer cells was shown to inhibit tumor development. Further research detected an important regulatory relationship between TMEM43 and VDAC1 . In addition, we found that USP7 affected the progression of HCC by regulating the ubiquitination level of TMEM43 through deubiquitination. Conclusions Our study demonstrated that USP7 participates in the growth of HCC tumors through TMEM43/VDAC1 .Our results suggest that USP7/TMEM43/VDAC1 may have predictive value and represent a new treatment strategy for HCC.

show abstract

Section: Discussionmentioning

confidence: 99%

TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination

Zhang,

Wang,

Yang

et al. 2024

Transl Gastroenterol Hepatol

View full text Add to dashboard Cite

show abstract

“… 21 There have been numerous reports showing that members of DUBs are highly elevated in various cancer cells and tissues at different stages of cancer. 22 , 23 This suggests that DUBs could be used as drug targets for cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma

Zhang¹,

Liu²,

Li³

et al. 2022

JIR

View full text Add to dashboard Cite

“… 79 Ubiquitin specific peptidase 27 (USP27), a novel therapeutic molecule, targets Cyclin E and retards the migration and metastasis of cancer cells. 80 , 81 Its expression in AD regulates synaptic plasticity and memory formation, 82 with induction of cell cycle activation in a Drosophila tauopathy model of AD. 83 However, deficiency of Cyclin E reduced spine volume and synapses and potentiated the memory impairment 84 key factors in AD pathogenesis.…”

Section: Overlapping Biological Molecules Between Glioma and Alzheime...mentioning

confidence: 99%

Therapeutic Potential of Nanomedicine in Management of Alzheimer’s Disease and Glioma

Anwar¹,

Naqvi²,

Sheikh³

et al. 2023

IJN

View full text Add to dashboard Cite

Neoplasm (Glioblastoma) and Alzheimer’s disease (AD) comprise two of the most chronic psychological ailments. Glioblastoma is one of the aggressive and prevalent malignant diseases characterized by rapid growth and invasion resulting from cell migration and degradation of extracellular matrix. While the latter is characterized by extracellular plaques of amyloid and intracellular tangles of tau proteins. Both possess a high degree of resistance to treatment owing to the restricted transport of corresponding drugs to the brain protected by the blood–brain barrier (BBB). Development of optimized therapies using advanced technologies is a great need of today. One such approach is the designing of nanoparticles (NPs) to facilitate the drug delivery at the target site. The present article elaborates the advances in nanomedicines in treatment of both AD as well as Gliomas. The intention of this review is to provide an overview of different types of NPs with their physical properties emphasizing their importance in traversing the BBB and hitting the target site. Further, we discuss the therapeutic applications of these NPs along with their specific targets. Multiple overlapping factors with a common pathway in development of AD and Glioblastoma are discussed in details that will assist the readers in developing the conceptual approach to target the NP for an aging population in the given circumstances with limitations of currently designed NPs, and the challenges to meet and the future perspectives.

show abstract

Roles and Mechanisms of Deubiquitinases (DUBs) in Breast Cancer Progression and Targeted Drug Discovery

Cited by 11 publications

References 131 publications

TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination

TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination

USP35 is a Potential Immunosuppressive Factor in Skin Cutaneous Melanoma

Therapeutic Potential of Nanomedicine in Management of Alzheimer’s Disease and Glioma

Contact Info

Product

Resources

About