Roles and regulation of the mucus barrier in the gut

Cornick, Steve; Tawiah, Adelaide; Chadee, Kris

doi:10.4161/21688370.2014.982426

Cited by 397 publications

(330 citation statements)

References 171 publications

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“…It keeps intestinal microbial flora separated from the epithelium and is involved in immune functions such as antigen presentation and tolerance [42]. Recently, the compromised mucus barrier role in pathogenesis of inflammatory bowel disease was highlighted [43].…”

Section: Discussionmentioning

confidence: 99%

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

El-Galil¹,

ElGhamrawy²

2015

J Cytol Histol

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Section: Discussionmentioning

confidence: 99%

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

El-Galil¹,

ElGhamrawy²

2015

J Cytol Histol

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“…The transmembrane mucins (MUC1, MUC4, MUC13 and MUC16) don’t play a role in mucus production. Under normal physiological conditions, goblet cells continually produce mucins, however, factors such as cytokines, toxins, microbes and microbial product can negative or positively regulate this process [23]. Disruption of this process has been associated with GI diseases.…”

Section: Introductionmentioning

confidence: 99%

Epithelial Barrier Function in Gut-Bone Signaling

Rios‐Arce

Collins

Schepper

et al. 2017

Advances in Experimental Medicine and Biology

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The intestinal epithelial barrier plays an essential role in maintaining host homeostasis. The barrier regulates nutrient absorption as well as prevents the invasion of pathogenic bacteria in the host. It is composed of epithelial cells, tight junctions, and a mucus layer. Several factors, such as cytokines, diet, and diseases can affect this barrier. These factors have been shown to increase intestinal permeability, inflammation, and translocation of pathogenic bacteria. In addition, dysregulation of the epithelial barrier can result in inflammatory diseases such as inflammatory bowel disease. Our lab and others have also shown that barrier disruption can have systemic effects including bone loss. In this chapter, we will discuss the current literature to understand the link between intestinal barrier and bone. We will discuss how inflammation, aging, dysbiosis and metabolic diseases can affect intestinal barrier-bone link. In addition, we will highlight the current suggested mechanism between intestinal barrier and bone.

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“…This viscous and complex mucus network is determinant against pathogens dissemination. Indeed, commensal and environmental microbes are immobilized in mucus via mucin binding which prevents reaching and damaging the underlying epithelium [17]. Johansson et al have shown that transgenic mice without protein mucin type 2 (MUC2 −/− ) develop rapidly intestinal inflammation and cancers which can partially explain the importance of mucus against pathogens invasion [18].…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

The role of mucus in cell-based models used to screen mucosal drug delivery

Lechanteur

Neves

Sarmento

2018

Advanced Drug Delivery Reviews

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The increasing interest in developing tools to predict drug absorption through mucosal surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro techniques for drug permeability assessment are less laborious, cheaper and address the concerns of using laboratory animals. Simultaneously, in vitro barrier models that thoroughly simulate human epithelia or mucosae may provide useful data to speed up the entrance of new drugs and new drug products into the clinics. Nevertheless, standard cell-based in vitro models that intend to reproduce epithelial surfaces often discard the role of mucus in influencing drug permeation/absorption. Biomimetic models of mucosae in which mucus production has been considered may not be able to fully reproduce the amount and architecture of mucus, resulting in biased characterization of permeability/absorption. In these cases, artificial mucus may be used to supplement cell-based models but still proper identification and quantification are required. In this review, considerations regarding the relevance of mucus in the development of cell-based epithelial and mucosal models mimicking the gastro-intestinal tract, the cervico-vaginal tract and the respiratory tract, and the impact of mucus on the permeability mechanisms are addressed. From simple epithelial monolayers to more complex 3D structures, the impact of the presence of mucus for the extrapolation to the in vivo scenario is critically analyzed. Finally, an overview is provided on several techniques and methods to characterize the mucus layer over cell-based barriers, in order to intimately reproduce human mucosal layer and thereby, improve in vitro/in vivo correlation.

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Roles and regulation of the mucus barrier in the gut

Abstract: These authors equally contributed to this work.

Cited by 397 publications

References 171 publications

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

The Effect of N. Acetylcysteine and Ginger on Acetic Acid Induced Colitis in Adult Male Albino Rat: Histological, Immunohistochemical and Morphometric Study

Epithelial Barrier Function in Gut-Bone Signaling

The role of mucus in cell-based models used to screen mucosal drug delivery

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