Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice

Yuan, Erdong; Lian, Yingyi; Li, Qiuhua; Lai, Zhaoxiang; Sun, Lin; Lai, Xingfei; Chen, Ruohong; Wen, Shuai; Zhu, Junquan; Zhang, Wenji; Sun, Shili

doi:10.1016/j.fshw.2022.03.032

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…In our previous study, we identified CA as the predominant flavonoid in Shibi tea and established a method to prepare CA from Shibi tea [ 30 ]. We also investigated for the first time that Shibi tea and CA alleviated alcoholic gastric injury by attenuating HCl/EtOH-induced oxidative stress in the stomach and inhibiting the NF-kB signaling pathway to suppress the expression of inflammatory factors in vivo [ 17 ]. However, the mitigating effects of EST and CA on liver injury have not yet been studied.…”

Section: Discussionmentioning

confidence: 99%

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Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

et al. 2022

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Liver injury is a significant public health issue nowadays. Shibi tea is a non-Camellia tea prepared from the dried leaves of Adinandra nitida, one of the plants with the greatest flavonoid concentration, with Camellianin A (CA) being the major flavonoid. Shibi tea is extensively used in food and medicine and has been found to provide a variety of health advantages. The benefits of Shibi tea and CA in preventing liver injury have not yet been investigated. The aim of this study was to investigate the hepatoprotective effects of extract of Shibi tea (EST) and CA in mice with carbon tetrachloride (CCl4)-induced acute liver injury. Two different concentrations of EST and CA were given to model mice by gavage for 3 days. Treatment with two concentrations of EST and CA reduced the CCl4-induced elevation of the liver index, liver histopathological injury score, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Western blotting and immunohistochemical analysis demonstrated that EST and CA regulated the oxidative stress signaling pathway protein levels of nuclear factor E2-related factor 2 (Nrf2)/heme-oxygenase-1 (HO-1), the expression of inflammatory cytokines, the phosphorylated nuclear factor-kappaB p65 (p-NF-κB)/nuclear factor-kappaB p65 (NF-κB) ratio, the phospho-p44/42 mitogen-activated protein kinase (p-MAPK), and the apoptosis-related protein levels of BCL2-associated X (Bax)/B cell leukemia/lymphoma 2 (Bcl2) in the liver. Taken together, EST and CA can protect against CCl4-induced liver injury by exerting antioxidative stress, anti-inflammation, and anti-apoptosis.

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Section: Discussionmentioning

confidence: 99%

“…Shibi tea was obtained from Zhengqi Agricultural Development Co., Ltd. in Yingde, and from Taihongyuan Agriculture Co., Ltd. in Xinyi, Maoming, Guangdong, China. The EST was prepared and the component analysis of EST was realized in our previous study [ 17 ]. CA (HPLC ≥ 98%) was obtained according to our previous study [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

et al. 2022

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“…SPF grade male KM mice (20 ± 2) g, (6)(7)(8) weeks were obtained from Liaoning Changsheng Biotechnology Laboratory and given unlimited access to food and water at 23 ℃ ± 2 ℃ with humidity set at 50% ± 10% for 12 h of light/dark cycle. According to previous studies, Bellayneh et al found that the flavonoid extracts (200 mg/kg and 400 mg/kg) from Solanum incanum L. (Solanaceae) leaves and roots had anti-gastric ulcer effects on albino mice, and found no significant side effects in mice through acute toxicity studies [45].…”

Section: Animal and Experiments Designmentioning

confidence: 99%

“…Therefore, search for safe and effective, especially extracting natural resources from plants as alternative drugs, still attracts a large number of researchers [7]. Examples of effective anti-ulcer agents identified from plant extracts include Adinandra nitida and camellianin A [8], Osyris quadripartite [9], and Cyperus conglomeratus [10] against the progression of acute gastric ulcer in mice.…”

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale flowers flavonoids enriched extract protects against acute ethanol-induced gastric ulcers via AMPK/PI3K signaling pathways

Zhang,

Xie,

Farag

et al. 2024

Food Science and Human Wellness

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Gastric ulcer is a widespread disease caused by various etiologies. Dendrobium officinale flowers exert several health benefits owing to their rich flavonoid content. In this study, protective effects and possible action mechanisms of D. officinale flowers' flavonoid enriched extract (DOFF) were assessed against gastric ulcer. The result of sodium nitrite-aluminum nitrate colorimetry showed that 52.34% of the total extractive was flavonoid, and ultra-high performance liquid chromatography time of flight mass spectrometer (UPLC-Q-TOF/MS) revealed the presence of 28 components in DOFF of which 14 belonged to flavonoids. In addition, in vivo assay revealed DOFF potential in reducing the formation of ethanol-induced gastric mucosal lesions, with drop-in ulcer index from 64.3 to 32.0. Similar results were revealed in human gastric mucosal epithelia cells (GES-1), with cells' viability to increase from 27.2% to 61.6% post DOFF administration. To analyzied the protect effect of DOFF, we used western blotting and immunofluorometric assay to revealed the expression levels of key proteins in cell pathways. The results showed that DOFF (320 μg/mL) could increase the level of oxidation marker protein (HO-1), apoptosis regulatory protein (Bcl-2) and autophagy marker (LC3β) by 50.84%, 43.85%, and 59.21% compared with ethanol-treated group respectively. Further analyzed of the mitochondrial activity and apoptosis pathway, we found that DOFF appeared to mitigate against ethanol-induced gastric mucosal injury via AMPK/mTOR/ULK1 and PI3K/AKT autophagy signaling pathways.

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“…Gastric ulcer is an in ammatory necrotic disease, which usually occurs in the inner wall of gastric mucosa or deep-seated ulcer, above 10% of people in the world suffer from this disease. Meanwhile, excessive alcohol ingestion is considered to be a major causative factor, resulting in the gastric mucosal epithelial cell apoptosis and destroy the mucosal protective layer 11 . Moreover, acetaldehyde and reactive oxygen species (ROS) were generated from alcohol consumption, leading to the impairment of antioxidant enzyme activity and the reduction of the antioxidant defenses 12 .…”

Section: Introductionmentioning

confidence: 99%

Comprehensive investigation on physicochemical properties, flavor profile, and anti-gastric ulcer potentialities of fermented oyster products

Liu

Yang

et al. 2022

Preprint

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Molecular sensory science and alcoholic gastric ulcer model were employed to explore the quality and gastroprotection of different fermented oyster products. The fermented oyster hydrolysates (OYF) were rich in amino acids and fatty acids. Lysine, leucine, and valine increased after fermentation, while UFAs exhibited a downward trend. The structure of different fermented oyster products was evaluated by FT-IR and UV, which were mainly manifested in the changes of protein and lipid. “Grass,” “acidic,” “milky,” “fishy,” and “metallic” were identified as the key sensory attributes. Forty-five volatiles were identified by gas chromatography-mass spectrometry. 4-Hexen-1-ol, hexanoic acid, 2-pentenyl-furan, and acetic acid contributed for the aroma profile after fermentation. Moreover, OYF could alleviate oxidative stress, reduce the expression of pro-inflammatory cytokines (TNF-α, IL-β, and NF-κB protein) and increase defense factors. The research demonstrates the relation of quality and bioactivities in OYF and provides a reference for the intensive processing of oyster industry.

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Roles of Adinandra nitida (Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice

Cited by 7 publications

References 37 publications

Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Dendrobium officinale flowers flavonoids enriched extract protects against acute ethanol-induced gastric ulcers via AMPK/PI3K signaling pathways

Comprehensive investigation on physicochemical properties, flavor profile, and anti-gastric ulcer potentialities of fermented oyster products

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