2012
DOI: 10.1128/iai.00434-12
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Roles of Chaperone/Usher Pathways of Yersinia pestis in a Murine Model of Plague and Adhesion to Host Cells

Abstract: Yersinia pestis and many other Gram-negative pathogenic bacteria use the chaperone/usher (CU) pathway to assemble virulence-associated surface fibers termed pili or fimbriae. Y. pestis has two well-characterized CU pathways: the caf genes coding for the F1 capsule and the psa genes coding for the pH 6 antigen. The Y. pestis genome contains additional CU pathways that are capable of assembling pilus fibers, but the roles of these pathways in the pathogenesis of plague are not understood. We constructed deletion… Show more

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Cited by 11 publications
(9 citation statements)
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“…The chaperone/usher (CU) pathway is a conserved secretion system dedicated to the biogenesis of pili in Gram-negative bacteria (1,(6)(7)(8), including pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Yersinia pestis, Acinetobacter baumannii, and intestinal and extraintestinal pathogenic Escherichia coli (9)(10)(11)(12)(13)(14)(15)(16). Pilus biogenesis by the CU pathway requires two specialized assembly components: a periplasmic chaperone and an integral outer membrane (OM) assembly and secretion platform termed the usher.…”
mentioning
confidence: 99%
“…The chaperone/usher (CU) pathway is a conserved secretion system dedicated to the biogenesis of pili in Gram-negative bacteria (1,(6)(7)(8), including pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Yersinia pestis, Acinetobacter baumannii, and intestinal and extraintestinal pathogenic Escherichia coli (9)(10)(11)(12)(13)(14)(15)(16). Pilus biogenesis by the CU pathway requires two specialized assembly components: a periplasmic chaperone and an integral outer membrane (OM) assembly and secretion platform termed the usher.…”
mentioning
confidence: 99%
“…This system is encoded on a virulence plasmid common to all three human Yersinia pathogens, and contributes two major virulence traits to Yersinia —anti-phagocytic and immunosuppression activities (Plano and Schesser, 2013 ). Several additional protein secretion systems, especially including a chromosomal T3SS, a T2SS, multiple T5SSs, and T6SSs as well as chaperone-usher systems, are predicted in the genomes of pathogenic Yersinia (Yen et al, 2008 ), and the functionality of some of these have been verified experimentally (Haller et al, 2000 ; Venecia and Young, 2005 ; Yen et al, 2007 ; Felek et al, 2008 , 2011 ; Lawrenz et al, 2009 ; Robinson et al, 2009 ; Hatkoff et al, 2012 ; Lenz et al, 2012 ; Pisano et al, 2012 ; Seo et al, 2012 ; Von Tils et al, 2012 ; Lane et al, 2013 ; Walker et al, 2013 ; Nair et al, 2015 ; Wang et al, 2015 ; Figure 1 ).…”
Section: Yersinia Biology and Classical Virulence Traitsmentioning
confidence: 99%
“…The chaperone-usher (C/U) pathway, which relies on SPase processing for all of its substrates, is responsible for the assembly of at least 30 different types of surface fibers that are vital for the initial stage of infection for pathogens such as E. coli, 133,134 Acinetobacter baumannii, 135 Salmonella enterica serovars, 136138 Yersinia species, 139,140 H. influenzae, 141 P. aeruginosa, 142 Bordetella pertussis, 143 K. pneumoniae, 144 and Proteus mirabilis . 145,146 These surface fibers function to provide adhesion to host cells, evade the immune response, and contribute to biofilm formation.…”
Section: A Direct Role For Spase In Gram-negative Virulencementioning
confidence: 99%