Roles of Cyclic Nucleotides in Platelet Function

Haslam, Richard J.

doi:10.1002/9780470720172.ch7

Cited by 34 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It took a few years to untangle the contributions of the cGMP in platelets. Some early studies showed that different compounds including collagen [ 17 , 18 , 19 ], ADP, epinephrine, and arachidonic acid [ 19 , 20 ] that initiate platelet secretion and aggregation elevated cGMP levels. Accordingly, based on these early studies it was hypothesized that cGMP plays a stimulatory role in platelets [ 17 , 21 , 22 ].…”

Section: Historical Aspects Of Cgmp Functions In Plateletsmentioning

confidence: 99%

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function

Gambaryan

2022

Cells

View full text Add to dashboard Cite

Circulating blood platelets are controlled by stimulatory and inhibitory factors, and a tightly regulated equilibrium between these two opposing processes is essential for normal platelet and vascular function. NO/cGMP/ Protein Kinase G (PKG) pathways play a highly significant role in platelet inhibition, which is supported by a large body of studies and data. This review focused on inconsistent and controversial data of NO/sGC/cGMP/PKG signaling in platelets including sources of NO that activate sGC in platelets, the role of sGC/PKG in platelet inhibition/activation, and the complexity of the regulation of platelet inhibitory mechanisms by cGMP/PKG pathways. In conclusion, we suggest that the recently developed quantitative phosphoproteomic method will be a powerful tool for the analysis of PKG-mediated effects. Analysis of phosphoproteins in PKG-activated platelets will reveal many new PKG substrates. A future detailed analysis of these substrates and their involvement in different platelet inhibitory pathways could be a basis for the development of new antiplatelet drugs that may target only specific aspects of platelet functions.

show abstract

Section: Historical Aspects Of Cgmp Functions In Plateletsmentioning

confidence: 99%

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function

Gambaryan

2022

Cells

View full text Add to dashboard Cite

show abstract

Binding of Adenosine Diphosphate by Human Platelet Membrane

Nachman

1975

Ciba Foundation Symposium 35 ‐ Biochemistry and Pharmacology of Platelets

View full text Add to dashboard Cite

The antithrombotic effect of prostaglandin E₁ immobilized on albuminated polymer matrix

Chandy

Sharma

1984

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

For intravascular implantation, a biofunctional surface seems to retard surface thrombosis upon synthetic materials. Prostaglandins, like PGI2, PGE1, and PGD2, etc., are believed to stimulate membrane-bound adenyl cyclase and thereby raise intracellular levels of c-AMP within platelets, which inhibit platelet adhesion and aggregation. A new procedure is suggested for the immobilization of prostaglandin E1 on an albuminated polymer matrix, through glutaraldehyde coupling. Materials thus prepared show dramatic antiplatelet effects, with regard to platelet adhesion, when compared with albumin-immobilized surfaces. The affinity of various modified surfaces toward platelet adhesion is studied, using washed platelets suspended in Tyrode's solution. Octane contact angle studies are used to develop an understanding of the varied nature of bound substrates at equilibrium on polymer surfaces. These are studied at the solid/liquid interface, which is closest to in vivo conditions. The plasma recalcification time demonstrates the anticoagulant properties of various surfaces. A possible role of PGE1 in reducing platelet activity in the presence and absence of vitamin C is discussed. This technique may be used in the development of non-thrombogenic surfaces on existing biomedical polymers. Simultaneous pharmaceutical modification of the blood with vitamin C may enhance the blood compatibility of the surface.

show abstract

Roles of Cyclic Nucleotides in Platelet Function

Cited by 34 publications

References 41 publications

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function

Binding of Adenosine Diphosphate by Human Platelet Membrane

The antithrombotic effect of prostaglandin E₁ immobilized on albuminated polymer matrix

Contact Info

Product

Resources

About

Roles of Cyclic Nucleotides in Platelet Function

Cited by 34 publications

References 41 publications

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function

Binding of Adenosine Diphosphate by Human Platelet Membrane

The antithrombotic effect of prostaglandin E1 immobilized on albuminated polymer matrix

Contact Info

Product

Resources

About

The antithrombotic effect of prostaglandin E₁ immobilized on albuminated polymer matrix