Roles of different neurochemical systems in mechanisms underlying the antinociceptive effect of extrahigh-frequency electromagnetic radiation

Abstract

We studied the effect of low-intensity extrahigh-frequency (EHF) electromagnetic radiation (EMR) on the duration of a pain behavioral reaction in rats under conditions of experimental induction of tonic pain (formalin test). The antinociceptive effect of EHF irradiation was modulated by suppression of the activity of a few neurochemical systems resulting from the blockade of receptors of opioid peptides, α-and β-adrenoreceptors, receptors of dopamine and melatonin, as well as from inhibition of serotonin synthesis. We demonstrated that all the respective neurochemical systems are to a certain extent involved in the mechanisms underlying the analgesic action of EHF EMR. Within an early phase of pain stress, functioning of the opioidergic and noradrenergic systems and the effects of melatonin play leading roles, while the activity of the serotonergic system plays such a role within the second (tonic) phase.

Action of red polarized light on the acupuncture point E-36 increases analgesic effect of corvitin

“…Ïðîòå â³äîìî, ùî íèçüêî³í-òåíñèâí³ åëåêòðîìàãí³òí³ ïîëÿ îïòè÷íîãî òà ì³êðîõâèëüîâîãî ä³àïàçîíó ñóòòºâî ïîòåí-ö³þþòü àíàëüãåòè÷íó ä³þ îï³î¿äíèõ ³ íåî-ï³î¿äíèõ àíàëüãåòèê³â [6,8]. Î÷åâèäíî, ôàðìàêîëîã³÷í³ àíàëüãåòèêè ³ âèñîêî÷àñ-òîòí³ íèçüêî³íòåíñèâí³ åëåêòðîìàãí³òí³ ïîëÿ âèÿâëÿþòü ñõîaeó ä³þ íà áîëüîâ³ ïîâåä³í-êîâ³ ðåàêö³¿ ó ãðèçóí³â, âèêîðèñòîâóþ÷è îäí³ é ò³ ñàì³ àíòèíîöèöåïòèâí³ ñèñòåìè ñòîâáóðà ìîçêó [7,12,21]. Ìè ââàaeàºìî, ùî ï³äñèëåííÿ àíàëüãåòè÷íîãî åôåêòó êîðâ³òèíó, êîëè â³í çàñòîñîâóºòüñÿ â êîìá³íàö³¿ ç íèçüêî³íòåíñèâíèì ÏÑ, òàêîae ìîaeå áóòè çóìîâëåíî àêòèâàö³ºþ îäíèõ ³ òèõ ñàìèõ àíòèíîöèöåïòèâíèõ ñèñòåì ñòîâáóðà ìîçêó.…”

"Antalgic Properties of Millimetric Waves on Chronical Pain: Is It Possible to Distinguish between Neuroplastic and Neuropathic Pain? A Report About 2 Fibromyalgia Cases"

“…Studies reporting a loss of effect with naloxone have strongly supported the hypothesis of an "opioid-induced" pathway based on central secretion of endorphins (CNS) triggered in the periphery (skin). In addition to fundamental molecular and cellular work, a large number of animal studies Radzievsky[7], Chuyan and Dzheldubayeva[8], Ziskin[9], and human investigations, have highlighted the potential value of MMWs in the field of pain relief or treatment.…”