Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

Matés, José M.; Segura, Juan; Alonso, Francisco; Márquez, Javier

doi:10.1016/j.freeradbiomed.2010.07.028

Cited by 253 publications

(120 citation statements)

References 160 publications

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“…Epidemiological and bio-monitoring studies previously showed that steel manufacturing is associated with production of several pollutants, including dioxins, sulfur oxides, nitrogen oxides, hydrocarbons, carbon monoxide, and transition metals, that may induce ROS generation, DNA damage and genome mutations (Danadevi et al, 2003;Goulart et al, 2005;Cavallo et al, 2008;Matés et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Analysis of plasma indices of redox homeostasis in dairy cows reared in polluted areas of Piedmont (northern Italy)

Spagnuolo

Cigliano

Nebbia

et al. 2012

Science of The Total Environment

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Steel manufacturing is responsible for the emission of pollutants, including dioxins and transition metals, inducing\ud reactive oxygen species generation and DNA damage. Dioxin pollution represents the major cause of milk and\ud dairy product contamination, in Italy, and is associated with oxidative stress-related processes, that may impair\ud health and performance of cows.We evaluated the effect of exposure to different concentrations of pollutants derived\ud from steel manufacturing on blood redox homeostasis of bovine cows. We analyzed two groups of dairy\ud cows (A, B), reared in two different polluted areas, and a control group of cows bred in an industry free area.\ud The extent of exposure to contaminants was defined by measuring dioxin level in bulk milk samples collected\ud from animals of each farm. This level was lower in milk of group A than in group B. Plasma concentrations of\ud retinol, alpha-tocopherol and ascorbate, the total antioxidant capacity, and the activities of superoxide dismutase\ud and glutathione peroxidase were higher in control group than in exposed groups. In particular, retinol and\ud tocopherol levelswere higher in the groupwith lower milk dioxin level. Plasma titers of protein-bound carbonyls\ud (PC), nitro-tyrosine, and hydroperoxideswere lower in control group than in A or B. Hydroperoxides and PC plasmaconcentrationswere\ud increased in the groupwith higher milk concentration of dioxin. Our results demonstrate\ud that, irrespective of the nature of chemicals inducing oxidativemodifications, the extent of damage to plasmaprotein\ud and lipid, is correlatedwith the concentration of dioxin in milk. So, the characterization of blood redox status\ud might be a useful tool for identifying animals exposed to environmental pollutants. Plasma concentrations of\ud retinol, alpha-tocopherol, PC and hydroperoxides could therefore represent good indices of the extent of animal\ud exposure, as they significantly change in groups with different milk concentrations of dioxi

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Section: Discussionmentioning

confidence: 99%

Analysis of plasma indices of redox homeostasis in dairy cows reared in polluted areas of Piedmont (northern Italy)

Spagnuolo

Cigliano

Nebbia

et al. 2012

Science of The Total Environment

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“…Lu and He (2005) studied Cd enrichment in soil by Ricinus communis L. at 10 mg/kg to 400 mg/kg concentrations, results showed that the maximum accumulation appeared at the concentration of 360 mg/kg but not 400 mg/kg. High concentrations could increase the content of heavy metals in tissue compartments of plants, but they weakened the accumulation ability conversely (Matés et al 2010). In our study, the existence of one ion promoted the uptake of the other ion.…”

Section: Biomass and Bioaccumulation Of CD And Pbmentioning

confidence: 99%

Changes of three organic acids in the process of Cd and Pb phytoextraction by Helianthus annuus L.

Niu¹,

Li²,

Sun³

et al. 2012

PLANT SOIL ENVIRON

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In the present study, sunflower was used to enrich the cadmium (Cd) and lead (Pb) in sand culture, and the changes of metals uptake, organic acids, pH, and redox potential were investigated. Results showed that the Cd and Pb accumulation was dissimilar in treatments. In single treatments of Cd or Pb, the amount of glutaric and lactic acids decreased with concentrations; the secretion of glutaric and glycolic acids in 5 mg/L Cd treatments were the highest at the 90 th day. In the mixed treatments of Cd and Pb, glutaric acids in cultures with Cd 5 mg/L + Pb 50 mg/L and Cd 10 mg/L + Pb 100 mg/L were higher than those in other treatments. Both lactic and glycolic acids reached the highest values in Cd 10 mg/L + Pb 100 mg/L treatments at the end of experiment. Besides, the Cd or Pb uptake showed various correlations with pH, redox potential, and organic acids, the reason might be that the presence of Cd or Pb influenced the organic acids exudation, and alterations of rhizosphere, including acidity, redox potential, and organic acids, impacted the bioavailability and phytoextraction of toxic metals conversely.

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“…Among these pollutants, heavy metals cannot be easily detoxified via degradation, resulting in their persistence in the environment. Many of these metals-e.g., Cu(II), Cd(II), Pb(II), Hg(II), Cr(VI), and Ni(II)-are carcinogens and are involved in several diseases, and have long been recognized as major marine pollutants [1,2].…”

Section: Introductionmentioning

confidence: 99%

Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals

2012

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A polydimethylsiloxane microfluidic chip has been developed for the estimation of toxic heavy metals based on measurement of mobility of marine microalgae. The chip is mainly composed of an upstream concentration gradient generator and a downstream perfusion-based chemotatic module. The processes of toxic liquid dilution and diffusion, microalgal culturing, cell stimulation, and online screening can be integrated in this chip, which makes it an attractive approach to simplify toxicity testing procedures. The microalgal motility was adopted as a microfluidic bioassay signal and was evaluated as the percentage of motile cells, curvilinear velocity, average path velocity, and straight line velocity. Two mobile marine microalgae, Platymonas subcordiformis and Platymonas helgolandica var. tsingtaoensis, were confined in the chemotatic module and stimulated by the eight concentration gradients of Cu and Cd generated by the concentration gradient generator. In all cases, a toxic response was detected (i.e., a dose-related inhibition of motility was observed). Only 1.5 h was needed to predict EC 50 values. Thus, the microfluidic chip developed was proved to be useful as a simple and rapid approach in heavy metal detection and might be expanded as a conventional test method in environmental toxicity assessment.

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Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms

Cited by 253 publications

References 160 publications

Analysis of plasma indices of redox homeostasis in dairy cows reared in polluted areas of Piedmont (northern Italy)

Analysis of plasma indices of redox homeostasis in dairy cows reared in polluted areas of Piedmont (northern Italy)

Changes of three organic acids in the process of Cd and Pb phytoextraction by Helianthus annuus L.

Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals

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