Roles of Fluoride on Octacalcium Phosphate and Apatite Formation on Amorphous Calcium Phosphate Substrate

Iijima, Mayumi; Onuma, Kazuo

doi:10.1021/acs.cgd.7b01717

Cited by 54 publications

(46 citation statements)

References 46 publications

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“…Although the present study did not directly demonstrate the presence of ACP in the outermost layer of enamel, its presence is suggested based on the findings that Mg ions are involved in the stability of ACP and that the Mg value was highest at the outermost layer of the Pr-E specimens. This finding is supported by the in-vitro study conducted by Iijima et al 26) , which showed the transformation of ACP to HAp via OCP.…”

Section: Formation Of Mg Present In the Interface Between Pre-eruptivsupporting

confidence: 68%

Acidic Calcium Phosphate Crystals Observed on the Outermost Layer of Human Enamel

Asada

Chiba

Shimoda

et al. 2019

J. Hard Tissue Biology.

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Many studies have been conducted to evaluate the timing of brushing and methods to suppress or halt the progression of acid erosion and initial caries formation, and to restore tooth enamel. However, the analyses in these studies were done from a macroscopic point of view, such as evaluating the change in the hardness of the enamel surface and the change in X-ray permeability, the morphological change due to crystal deposits on the enamel surface has not been elucidated. The purpose of this study was to investigate how crystals on the enamel surface differ when they are in contact with oral cavity liquids such as saliva versus no contact with these liquids. In addition, we assessed the condition of initial caries in which no substantial defect is observable, from the morphological perspective by using elemental analysis and observations with a transmission electron microscope (TEM). We also considered the causes of crystal formation on the enamel surface. As a result, the outermost layer in the pre-eruptive enamel contained a large amount of Mg, which is a stabilizer of amorphous calcium phosphate, suggesting that the layer contains acidic calcium phosphates. It was suggested that tricalcium phosphate, dicalcium phosphate dihydrate, octacalcium phosphate, etc. form a layer on the surface of post-eruptive enamel with no caries and in post-eruptive enamel with caries exposed to saliva in the oral cavity and the layer containing calcium phosphate have higher acid resistance than HAp. The information from this study can be applied to basic clinical research on remineralization therapy and non-invasive treatments of initial caries.

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Section: Formation Of Mg Present In the Interface Between Pre-eruptivsupporting

confidence: 68%

Acidic Calcium Phosphate Crystals Observed on the Outermost Layer of Human Enamel

Asada

Chiba

Shimoda

et al. 2019

J. Hard Tissue Biology.

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“…On the other hand, the low fluoride content of the BioMinF ® (in contrast to the high fluoride content of the utilized fluoride gel), allowed the penetration of BioMinF ® rich content of calcium and phosphate through the porous enamel sub-surface, causing the re-mineralization of the demineralized enamel lesion rather than remineralizing the outer enamel surface, as was observed when using fluoride as a sole remineralizing agent. Moreover, previous research showed that the presence of low concentration of fluoride in the BioMinF ® glass facilitated apatite formation, since fluorapatite forms at about a unit of pH lower than hydroxyapatite, and fluoride is known to catalyze the conversion of brushite, octacalcium phosphate, and amorphous calcium phosphate to apatite [ 27 ]; which may explain the decrease in the roughness of the BioMinF ® glass specimens’ SEM-EDS images, due to the repair action exerted by the BioMinF ® paste [ 13 , 27 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel Fluoride Containing Bioactive Glass Paste is Capable of Re-Mineralizing Early Caries Lesions

et al. 2018

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White-spot-lesions (WSL) are a common complication associated with orthodontic treatment. In the current study, the remineralization efficacy of a BiominF® paste was compared to the efficacy of a fluoride gel. Methods: Orthodontic brackets were bonded to 60 human premolars buccal surfaces, which were covered with varnish, except a small treatment area (3 mm2). All specimens were challenged by a demineralization solution for 4 days. Specimens were assigned into 4 groups: BiominF® paste, Fluoride (4-min application), fluoride (twenty four hours application), and the control (n = 15). After cross-sectioning, enamel slabs having a thickness of approximately 100–120 μm were obtained. A TMR (Transverse Micro Radiography) technique was used to observe the sub-surface enamel lesions’ depth and mineral density, and their response to the remineralization protocols. One way ANOVA was used to analyze the results (α = 0.05). The top and the cross-sectional surfaces were observed using SEM/EDS. Results: Specimens treated with BiominF® paste showed significant decrease in delta z values, however lesion depth showed no significant difference when compared to the other three groups (p < 0.05). SEM/EDS observation showed the formation of crystal like structures on top of enamel demineralized surfaces, when treated with BiominF® paste. In conclusion BiominF® paste can be considered an effective remineralizing agent for white spot Lesions.

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“…reported that Mg ions suppressed the conversion of ACP to HAP. Iijima et al 29) . added fluoride to Ca and P ion solutions, and when the fluoride concentration was increased to 1 ppm or more, the nano-rod hydroxyapatite precipitated directly from the base of ACP plate without going through an OCP step.…”

Section: Continuous Crystal Change Of Calcium Phosphatementioning

confidence: 99%

Electron Microscopic Study on the Formation of Hardened Molds of Calcium Phosphate Crystals Containing Gelatin

Tai

Asada

Chiba

et al. 2019

J. Hard Tissue Biology.

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Fundamental studies on biocompatible materials were conducted using the mechanism of dentin formation as a model. Hydroxyapatite and fluorinated apatite were synthesized in a gelatin solution. Synthesized apatite was pressed under vacuum, and the mechanical strength was investigated. A hardened mold was prepared by adding amorphous calcium phosphate (ACP). Then, changes in the crystals of the hardened mold dipped in distilled water or 1 ppm fluoride solution were observed with a transmission electron microscope. The results showed that the crystal growth of apatite synthesized in 1% gelatin was suppressed. Moreover, small and homogenous granular apatite was formed in the precipitate synthesized with fluorine. Gelatin contributed to the reduction of brittleness of the hardened mold, and thus a high cutting resistance value was obtained. Furthermore, acceleration of crystal growth and aggregation of fine crystals were observed in the hardened mold when ACP was added to the solution.

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Roles of Fluoride on Octacalcium Phosphate and Apatite Formation on Amorphous Calcium Phosphate Substrate

Cited by 54 publications

References 46 publications

Acidic Calcium Phosphate Crystals Observed on the Outermost Layer of Human Enamel

Acidic Calcium Phosphate Crystals Observed on the Outermost Layer of Human Enamel

A Novel Fluoride Containing Bioactive Glass Paste is Capable of Re-Mineralizing Early Caries Lesions

Electron Microscopic Study on the Formation of Hardened Molds of Calcium Phosphate Crystals Containing Gelatin

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