Roles of glutamate and GABA of the Kölliker-Fuse nucleus in generating the cardiovascular chemoreflex

Mirzaei-Damabi, Nafiseh; Hatam, Masoumeh; Yeganeh, Fahimeh; Ketabchi, Farzaneh; Nasimi, Ali

doi:10.1007/s00424-020-02422-0

Cited by 8 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…L. rennini, produces γ-aminobutyric acid (GABA), even with coexisting lactic acid and common salt in the medium (Hanya et al, 2012). GABA has essential roles in cardiovascular and cerebral blood pressure, promotes the balance of amino acid metabolism in human health, and regulates immune function (Mirzaei-Damabi et al, 2020). In addition, the results indicated that P. brenneri was also dominant in Dajiang samples.…”

Section: Discussionmentioning

confidence: 92%

Microbial Communities and Physicochemical Characteristics of Traditional Dajiang and Sufu in North China Revealed by High-Throughput Sequencing of 16S rRNA

Liang

Xie

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

The process of soybean fermentation has been practiced for more than 3,000 years. Although Dajiang and Sufu are two popular fermented soybean products consumed in North China, limited information is available regarding their microbial composition. Hence, the current study sought to investigate, and compare, the physicochemical indicators and microbial communities of traditional Dajiang and Sufu. Results showed that the titratable acidity (TA), and salinity, as well as the lactic acid, and malic acid contents were significantly higher in Sufu samples compared to Dajiang. Furthermore, Sufu samples contain abundant sucrose and fructose, while the acetic acid content was lower in Sufu compared to Dajiang samples. Moreover, the predominant bacterial phyla in Dajiang and Sufu samples were Firmicutes and Proteobacteria, while the major genera comprise Bacillus, Lactobacillus, Tetragenococcus, and Weissella. Moreover, Dajiang samples also contained abundant Pseudomonas, and Brevundimonas spp., while Halomonas, Staphylococcus, Lysinibacillus, Enterobacter, Streptococcus, Acinetobacter, and Halanaerobium spp. were abundant in Sufu samples. At the species level, Bacillus velezensis, Tetragenococcus halophilus, Lactobacillus rennini, Weissella cibaria, Weissella viridescens, Pseudomonas brenneri, and Lactobacillus acidipiscis represented the major species in Dajiang, while Halomonas sp., Staphylococcus equorum, and Halanaerobium praevalens were the predominant species in Sufu. Acetic acid and sucrose were found to be the primary major physicochemical factor influencing the bacterial communities in Dajiang and Sufu, respectively. Furthermore, Bacillus subtilis is strongly correlated with lactic acid levels, L. acidipiscis is positively correlated with acetic acid levels, while Staphylococcus sciuri and S. equorum are strongly, and positively, correlated with malic acid. Following analysis of carbohydrate and amino acid metabolism in all samples, cysteine and methionine metabolism, as well as fatty acid biosynthesis-related genes are upregulated in Dajiang compared to Sufu samples. However, such as the Staphylococcus, W. viridescens, and P. brenneri, as potentially foodborne pathogens, existed in Dajang and Sufu samples. Cumulatively, these results suggested that Dajiang and Sufu have unique bacterial communities that influence their specific characteristics. Hence, the current study provides insights into the microbial community composition in Dajiang and Sufu samples, which may facilitate the isolation of functional bacterial species suitable for Dajiang and Sufu production, thus improving their production efficiency.

show abstract

Section: Discussionmentioning

confidence: 92%

Microbial Communities and Physicochemical Characteristics of Traditional Dajiang and Sufu in North China Revealed by High-Throughput Sequencing of 16S rRNA

Liang

Xie

et al. 2021

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…However, many studies have shown that sevoflurane affects the cardiovascular system by modulating NMDA receptors. Mirzaei‐Damabi et al found that the glutamate in the Kölliker–Fuse nucleus plays a role in generating the cardiovascular chemoreflex 47 . In their study, microinjection of the NMDA receptor antagonist AP5 into Kölliker–Fuse significantly attenuated blood pressure and bradycardia responses.…”

Section: Discussionmentioning

confidence: 82%

“…Mirzaei-Damabi et al found that the glutamate in the Kölliker-Fuse nucleus plays a role in generating the cardiovascular chemoreflex. 47 In their study, microinjection of the NMDA receptor antagonist AP5 into Kölliker-Fuse significantly attenuated blood pressure and bradycardia responses. Another study showed that ethanol may cause hypotension by acting on the glutamatergic NMDA receptor/NO/GABA pathway in the RVLM.…”

Section: Grin2b Genementioning

confidence: 92%

Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane

Zhao

Huang

Zhong

et al. 2022

The Journal of Clinical Pharma

View full text Add to dashboard Cite

The susceptibility of different individuals to anesthetics varies widely, and sevoflurane is no exception. We hypothesized that polymorphisms in genes involved in pharmacokinetics and pharmacodynamics may explain this variation. A total of 151 individuals undergoing otorhinolaryngology surgery were included. The influence of genetic polymorphisms on sevoflurane sensitivity were investigated through SNaPshot technology. Individuals carrying KCNK2 rs6686529 G > C, MTRR rs3733784 TT, rs2307116 GG, or rs1801394 AA polymorphisms had a higher sensitivity to the sedative effect of sevoflurane than those without those polymorphisms. The univariate linear regression analysis indicated that MTRR rs3733784 TT, rs2307116 GG, and rs1801394 AA were potentially significant predictors of higher sensitivity to the sedative effect of sevoflurane. Moreover, CYP2E1 rs3813867 G > C and rs2031920 C > T, GABRG1 rs279858 T > C, KCNK3 rs1275988 CC, GRIN2B rs1806201 GG, MTRR rs2307116 G > A, and rs1801394 A > G were associated with a higher sensitivity to the cardiovascular effect of sevoflurane. Our results suggested that 9 single nucleotide polymorphisms in genes involved in metabolizing enzymes, transport proteins, target proteins of sevoflurane and folate metabolism may help to explain individual differences in the susceptibility to the sedative or cardiovascular effect of sevoflurane.

show abstract

“…230,231 GABA is an important neurotransmitter with roles in the regulation of the central nervous system, psychosocial system, cardiovascular disease, and renal function. [232][233][234][235] A recent clinical study demonstrated that the serum level of GABA can be used as a biomarker for the diagnosis and treatment of osteoporosis as its level is significantly reduced in women with osteoporosis. 236 GABA can stimulate osteoblastogenesis by upregulating osteogenesis-related genes via activating GABAB receptors and inhibiting the activity of inflammatory cytokines (IL-6 and CRP) and reactive oxygen species (ROS).…”

Section: F I G U R Ementioning

confidence: 99%

“…are the main bacteria involved in this process 230,231 . GABA is an important neurotransmitter with roles in the regulation of the central nervous system, psychosocial system, cardiovascular disease, and renal function 232‐235 . A recent clinical study demonstrated that the serum level of GABA can be used as a biomarker for the diagnosis and treatment of osteoporosis as its level is significantly reduced in women with osteoporosis 236 …”

Section: Gm‐derived Metabolites and Bone Metabolismmentioning

confidence: 99%

Gut microbiota and bone metabolism

Chen

Liu

et al. 2021

The FASEB Journal

View full text Add to dashboard Cite

Osteoporosis is the most common metabolic skeletal disease. It is characterized by the deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even bone fractures. Accumulating evidence has indicated that there is an inextricable relationship between the gut microbiota (GM) and bone homeostasis involving host–microbiota crosstalk. Any perturbation of the GM can play an initiating and reinforcing role in disrupting the bone remodeling balance during the development of osteoporosis. Although the GM is known to influence bone metabolism, the mechanisms associated with these effects remain unclear. Herein, we review the current knowledge of how the GM affects bone metabolism in health and disease, summarize the correlation between pathogen‐associated molecular patterns of GM structural components and bone metabolism, and discuss the potential mechanisms underlying how GM metabolites regulate bone turnover. Deciphering the complicated relationship between the GM and bone health will provide new insights into the prevention and treatment of osteoporosis.

show abstract

Roles of glutamate and GABA of the Kölliker-Fuse nucleus in generating the cardiovascular chemoreflex

Cited by 8 publications

References 40 publications

Microbial Communities and Physicochemical Characteristics of Traditional Dajiang and Sufu in North China Revealed by High-Throughput Sequencing of 16S rRNA

Microbial Communities and Physicochemical Characteristics of Traditional Dajiang and Sufu in North China Revealed by High-Throughput Sequencing of 16S rRNA

Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane

Gut microbiota and bone metabolism

Contact Info

Product

Resources

About