Roles of liposome composition and temperature in distribution of amphotericin B in serum lipoproteins

Wasan, Kishor M.; Brazeau, Gayle A.; Keyhani, Afsaneh; Hayman, A.; López-Berestein, Gabriel

doi:10.1128/aac.37.2.246

Cited by 86 publications

(74 citation statements)

References 18 publications

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“…Outros estudos avaliaram a interação de AB com lipoproteínas e mostraram que a alteração da composição lipídica vascular levou a redução dos efeitos tóxicos de AB-DOC (Wasan et al, 1993;Wasan et al, 1994;Chavanet et al, 1994;Marzzullo et al, 1996), na presença de lipoproteínas a forma livre de AB apresentou-se reduzida e sua concentração foi menor quando as lipoproteínas foram obtidas de soro pós-prandial, demonstrando que a dieta influenciou na quantidade de fármaco livre tóxico (Chavanet et al, 1994). Assim, a associação de AB com diferentes frações do plasma, assim como sua maior solubilização nestas frações, pode ser um fator responsá-vel pela redução da toxicidade do antifúngico.…”

Section: Mecanismos Propostos Para Redução De Toxicidadeunclassified

“…Assim, a associação de AB com diferentes frações do plasma, assim como sua maior solubilização nestas frações, pode ser um fator responsá-vel pela redução da toxicidade do antifúngico. Wasan et al (1993) realizaram diversos experimentos para elucidar a diminuída toxicidade de AmBisome em consideração à associação de AB com lipoproteínas. Seus resultados mostraram que modificações na temperatura e na composição lipídica do lipossoma implicaram alteração na distribuição da AB entre HDL e LDL.…”

Section: Mecanismos Propostos Para Redução De Toxicidadeunclassified

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Eficiência terapêutica das formulações lipídicas de anfotericina B

Filippin

Souza

2006

Rev. Bras. Cienc. Farm.

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Section: Mecanismos Propostos Para Redução De Toxicidadeunclassified

Eficiência terapêutica das formulações lipídicas de anfotericina B

Filippin

Souza

2006

Rev. Bras. Cienc. Farm.

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“…However, the pharmacokinetics, tissue distribution, and extents of nephrotoxic effects of L-AmpB in diabetic rats were unchanged (20). In addition, we have demonstrated that AmpB associates predominantly with high-density lipoproteins (HDL) following a 1-h incubation at 37°C in human serum, and the amount of AmpB associated with HDL increases when AmpB is incorporated into negatively charged liposomes composed of DMPC and DMPG (17 animals were allowed to recover for 48 h after the surgical procedure. Water and rat chow (Ralston Purina Co., St. Louis, Mo.)…”

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Concentrations in serum and distribution in tissue of free and liposomal amphotericin B in rats during continuous intralipid infusion

Wasan

Grossie

López-Berestein

1994

Antimicrob Agents Chemother

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The influences of Intralipid (IL) and 0.45% normal-saline infusions on the concentration in serum and distribution in tissue of amphotericin B (AmpB) and liposomal amphotericin B (L-AmpB) in rats were compared. In animals receiving a continuous IL infusion, concentrations of AmpB in kidneys and lungs were significantly higher, but the concentration of AmpB in serum was significantly lower in animals administered AmpB versus those given L-AmpB. In animals receiving a continuous normal-saline infusion concentrations of AmpB in kidneys and the spleen were significantly higher, but the concentration of AmpB in serum was significantly lower in animals administered AmpB versus those given L-AmpB. These results suggest that the increased total serum cholesterol and high-density lipoprotein cholesterol during the IL infusion decreased the clearance of AmpB from the bloodstream and decreased the L-AmpB concentration in the kidney and lung.Amphotericin B (AmpB) remains one of the most effective and widely used agents in the treatment of systemic fungal infections; however, its use is limited by dose-dependent nephrotoxicity (3). When AmpB is incorporated into liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) (7:3, wt/wt) with a lipid-to-drug ratio of 10:1, wt/wt, it is as effective as, but less toxic than, Fungizone (which consists of AmpB and desoxycholate in a 5:4, wt/wt, ratio) in experimental animal models (9, 10) and patients (8) with systemic fungal infections. However, the mechanisms that result in the enhanced therapeutic index of liposomal AmpB (L-AmpB) are not fully understood.Previous pharmacokinetic and tissue distribution studies have described AmpB's disposition in the body as having a central compartment and two peripheral compartments (2).AmpB and L-AmpB have a large volume of distribution in humans as a result of high accumulation within tissues, and AmpB has a long terminal half-life, 15 days (2), probably due to the slow release of the drug from tissue sites.We have demonstrated a smaller area under the serum AmpB concentration-time curve, greater volume of distribution at steady state, and faster systemic clearance of AmpB in an induced diabetic murine model which indirectly results in hyperlipidemia and hyperlipoproteinemia versus normolipidemic rats (20). Furthermore, we observed a lower distribution of AmpB in kidney and liver tissues and smaller nephrotoxic effects of AmpB in diabetic rats. However, the pharmacokinetics, tissue distribution, and extents of nephrotoxic effects of L-AmpB in diabetic rats were unchanged (20). In addition, we have demonstrated that AmpB associates predominantly with high-density lipoproteins (HDL) following a 1-h incubation at 37°C in human serum, and the amount of AmpB associated with HDL increases when AmpB is incorporated into negatively charged liposomes composed of DMPC and DMPG (17).

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“…Судьба лекарств, снабжённых наносистемами транспорта, в кровотоке определяется их взаимодействием с компонентами крови, клетками тканей-мишеней и здоровых тканей [3][4][5][6]. Для опухолевых тканей и областей воспаления характерен "эффект повышенной проницаемости и удерживания" (enhanced permeability and retention, EPR) [7].…”

Section: Introductionunclassified

The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment

Sanzhakov

et al. 2016

BIOMED KHIM

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The use of targeted transport systems for drug delivery is a promising approach to improve pharmacokinetics of drug substances, accumulation in the lesion. In this study we have obtained and characterized the pharmaceutical composition of doxorubicin in colloidal nanoparticles equipped with targeted conjugates based on folic acid and biotin with dodecylamine. The inclusion of the address fragments into colloidal nanopartical was carried out without surface and drug substance modification The accumulation of anthracycline antibiotic doxorubicin in tumor tissue was compared in Lewis lung carcinoma mouse models after intravenous administration of the composition of colloidal nanoparticles with targeted conjugates biotin-dodecylamine and folic acid-dodecylamine or free doxorubicin. It was shown that the doxorubicin accumulation in tumor tissue when administered in drug compositions with targeted fragments are 2 times higher for the folic acid-dodecylamine conjugate and 1.4 times higher for the biotin-dodecylamine conjugate

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Roles of liposome composition and temperature in distribution of amphotericin B in serum lipoproteins

Cited by 86 publications

References 18 publications

Eficiência terapêutica das formulações lipídicas de anfotericina B

Eficiência terapêutica das formulações lipídicas de anfotericina B

Concentrations in serum and distribution in tissue of free and liposomal amphotericin B in rats during continuous intralipid infusion

The in vivo study of the medicinal composition property of doxorubicin as a part of colloidal nanoparticles with the address fragment

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