Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury

Wu, Guanggeng; Wen, Xiaoyue; Kuang, Rui; Lui, KoonHei Winson; He, Bo; Li, Ge; Zhu, Zhaowei

doi:10.1007/s10571-023-01442-5

Cited by 11 publications

(2 citation statements)

References 80 publications

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“…Macrophages also play an indispensable role in Schwann cell-mediated nerve regeneration after PNI [12,22]. Macrophages are actively recruited by repair Schwann cells and infiltrate into the injured nerve, where they are critical for the efficient removal of degenerated myelin debris through phagocytosis, creating a positive environment for axonal regrowth [23,24] (Figure 1F).…”

Section: Discussionmentioning

confidence: 99%

“…However, aging significantly impacts this Schwann cell response, leading to decreased de-differentiation potential, impaired remyelination gene programs, and reduced trophic support [11,21]. In addition to Schwann cells, macrophages also play an essential role in PNI [12,22]. Following nerve injury, macrophages are rapidly activated and recruited to the site of damage, performing crucial functions through phagocytosis of myelin debris and secretion of cytokines, chemokines, and growth factors that support Schwann cell de-differentiation, proliferation, and remyelination [18,23,24].…”

Section: Introductionmentioning

confidence: 99%

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GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice

Su,

Huang,

Thomas

et al. 2024

IJMS

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Peripheral nerve injuries (PNIs) represent a significant clinical challenge, particularly in elderly populations where axonal remyelination and regeneration are impaired. Developing therapies to enhance these processes is crucial for improving PNI repair outcomes. Glutamate carboxypeptidase II (GCPII) is a neuropeptidase that plays a pivotal role in modulating glutamate signaling through its enzymatic cleavage of the abundant neuropeptide N-acetyl aspartyl glutamate (NAAG) to liberate glutamate. Within the PNS, GCPII is expressed in Schwann cells and activated macrophages, and its expression is amplified with aging. In this study, we explored the therapeutic potential of inhibiting GCPII activity following PNI. We report significant GCPII protein and activity upregulation following PNI, which was normalized by the potent and selective GCPII inhibitor 2-(phosphonomethyl)-pentanedioic acid (2-PMPA). In vitro, 2-PMPA robustly enhanced myelination in dorsal root ganglion (DRG) explants. In vivo, using a sciatic nerve crush injury model in aged mice, 2-PMPA accelerated remyelination, as evidenced by increased myelin sheath thickness and higher numbers of remyelinated axons. These findings suggest that GCPII inhibition may be a promising therapeutic strategy to enhance remyelination and potentially improve functional recovery after PNI, which is especially relevant in elderly PNI patients where this process is compromised.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice

Su,

Huang,

Thomas

et al. 2024

IJMS

View full text Add to dashboard Cite

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The Exosome‐Mediated Bone Regeneration: An Advanced Horizon Toward the Isolation, Engineering, Carrying Modalities, and Mechanisms

Zhu,

Wang,

Wang

et al. 2024

Adv Healthcare Materials

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Exosomes, nanoparticles secreted by various cells, composed of a bilayer lipid membrane, and containing bioactive substances such as proteins, nucleic acids, metabolites, etc., have been intensively investigated in tissue engineering owing to their high biocompatibility and versatile biofunction. However, there is still a lack of a high‐quality review on bone defect regeneration potentiated by exosomes. In this review, we will first introduce the biogenesis and isolation methods of exosomes, More importantly, the engineered exosomes of the current state of knowledge will be discussed intensively in this review. Afterward, the biomaterial carriers of exosomes and the mechanisms of bone repair elucidated by compelling evidence will be presented. Thus, future perspectives and concerns are revealed to help devise advanced modalities based on exosomes to overcome the challenges of bone regeneration. We totally believe this review will attract special attention from clinicians and provide promising ideas for their future works.This article is protected by copyright. All rights reserved

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The amelioration effects of ankaferd blood stopper, platelet gel, and Momordica charantia on peripheral nerve injury in the rats: a stereological and ultrastructural study

Altun,

Önger,

Geuna

et al. 2024

Histochem Cell Biol

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Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury

Cited by 11 publications

References 80 publications

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice

The Exosome‐Mediated Bone Regeneration: An Advanced Horizon Toward the Isolation, Engineering, Carrying Modalities, and Mechanisms

The amelioration effects of ankaferd blood stopper, platelet gel, and Momordica charantia on peripheral nerve injury in the rats: a stereological and ultrastructural study

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