Roles of mechanosensitive ion channels in immune cells

Xia, Kexin; Chen, Xiaolin; Wang, Wenyan; Liu, Qianwen; Zhao, Mai; Ma, Jiacheng; Jia, Hao

doi:10.1016/j.heliyon.2023.e23318

Heliyon

2024

DOI: 10.1016/j.heliyon.2023.e23318

|View full text |Cite

Roles of mechanosensitive ion channels in immune cells

Kexin Xia,

Xiaolin Chen,

Wenyan Wang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

Nagase,

Nagase

2024

Hypertens Res

View full text Add to dashboard Cite

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

Nagase,

Nagase

2024

Hypertens Res

View full text Add to dashboard Cite

Functional Role of Piezo1 in the Human Eosinophil Cell Line AML14.3D10: Implications for the Immune and Sensory Nervous Systems

Hwang,

Song,

Choi

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Mechanosensitive ion channels, particularly Piezo channels, are widely expressed in various tissues. However, their role in immune cells remains underexplored. Therefore, this study aimed to investigate the functional role of Piezo1 in the human eosinophil cell line AML14.3D10. We detected Piezo1 mRNA expression, but not Piezo2 expression, in these cells, confirming the presence of the Piezo1 protein. Activation of Piezo1 with Yoda1, its specific agonist, resulted in a significant calcium influx, which was inhibited by the Piezo1-specific inhibitor Dooku1, as well as other nonspecific inhibitors (Ruthenium Red, Gd3+, and GsMTx-4). Further analysis revealed that Piezo1 activation modulated the expression and secretion of both pro-inflammatory and anti-inflammatory cytokines in AML14.3D10 cells. Notably, supernatants from Piezo1-activated AML14.3D10 cells enhanced capsaicin and ATP-induced calcium responses in the dorsal root ganglion neurons of mice. These findings elucidate the physiological role of Piezo1 in AML14.3D10 cells and suggest that factors secreted by these cells can modulate the activity of transient receptor potential 1 (TRPV1) and purinergic receptors, which are associated with pain and itch signaling. The results of this study significantly advance our understanding of the function of Piezo1 channels in the immune and sensory nervous systems.

show abstract

TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Koskimäki,

Tojkander

2024

Sensors

View full text Add to dashboard Cite

Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes. These proteins have various subtype-specific functions, serving, for example, as sensors for pain, pressure, pH, and mechanical extracellular stimuli. The sensing of extracellular cues by TRPV4 triggers Ca2+-influx through the channel, subsequently coordinating numerous intracellular signaling cascades in a spatio-temporal manner. As TRPV channels play such a wide role in various cellular and physiological functions, loss or impaired TRPV protein activity naturally contributes to many pathophysiological processes. This review concentrates on the known functions of TRPV4 sensor proteins and their potential as a therapeutic target.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Roles of mechanosensitive ion channels in immune cells

Cited by 3 publications

References 54 publications

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

Functional Role of Piezo1 in the Human Eosinophil Cell Line AML14.3D10: Implications for the Immune and Sensory Nervous Systems

TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Contact Info

Product

Resources

About