Roles of MiR-101 and its Target Gene Cox-2 in Early Diagnosis of Cervical Cancer in Uygur Women

Chen, Lin; Huang, Fei; Zhang, Yajing; Tuokan, Talafu; Kuerban, Gulinaer

doi:10.7314/apjcp.2014.15.1.45

Cited by 23 publications

(14 citation statements)

References 17 publications

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“…The most significant up-to-date findings of miRNAs in cancer concentrate more on the potential of cancer-related miRNAs (oncomiRs) as biomarkers for diagnosis (Lin et al, 2014), prognosis and therapy. Furthermore, therapeutic approaches involving the re-introduction of miRNAs lost in cancer or inhibition of oncogenic miRNAs are rapidly being developed.…”

Section: Micrornas As Potential Biomarkers For Cancer Diagnosis and Pmentioning

confidence: 99%

“…Recently, the findings of miRNAs in body fluids, such as serum, urine and colostrum (Hanke et al, 2010;Link et al, 2010) have strengthened investigations into the use of miRNAs as non-invasive biomarkers of disease and a therapeutic response in a range of cancers including lung cancer, ovarian cancer, colorectal cancer, renal cancer, glioblastoma, prostate cancer and breast cancer (Cortez et al, 2012). In recent times, Lin et al (2014) characterized miRNAs expression profiles in cervical cancer of Uygur women to identify the biomarkers for early diagnosis. Their data showed that the expression of Cox-2 protein level was significantly increased in cervical cancer.…”

Section: Micrornas As Potential Biomarkers For Cancer Diagnosis and Pmentioning

confidence: 99%

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MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Kavitha¹,

Vijayarathna²,

Jothy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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MicroRNAs (miRNAs) are short non-coding RNAs of 20-24 nucleotides that play important roles in carcinogenesis. Accordingly, miRNAs control numerous cancer-relevant biological events such as cell proliferation, cell cycle control, metabolism and apoptosis. In this review, we summarize the current knowledge and concepts concerning the biogenesis of miRNAs, miRNA roles in cancer and their potential as biomarkers for cancer diagnosis and prognosis including the regulation of key cancer-related pathways, such as cell cycle control and miRNA dysregulation. Moreover, microRNA molecules are already receiving the attention of world researchers as therapeutic targets and agents. Therefore, in-depth knowledge of microRNAs has the potential not only to identify their roles in cancer, but also to exploit them as potential biomarkers for cancer diagnosis and identify therapeutic targets for new drug discovery.

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Section: Micrornas As Potential Biomarkers For Cancer Diagnosis and Pmentioning

confidence: 99%

Section: Micrornas As Potential Biomarkers For Cancer Diagnosis and Pmentioning

confidence: 99%

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Kavitha¹,

Vijayarathna²,

Jothy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…The appearance in HUVEC showed no significant difference between Fa-NPs/DNA and NPs/ DNA. The studies of cervical cancer gene diagnosis and therapy in Asia countries have been carried out by several researches and gained excellent results (Kahla et al, 2014;Lin et al, 2014;Ma et al, 2014;Zhao et al, 2014). The results in this study suggesting much higher affinity and selecting capability of the Fa containing gene loaded NPs to cervical cancer cells.…”

Section: In Vitro Gene Delivery Effectmentioning

confidence: 57%

Cervical Cancer Gene Therapy by Gene Loaded PEG-PLA Nanomedicine

Liu¹,

Han²,

Tang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Many microRNAs were confirmed to target COX-2. For example, Lin et al have found that MicroRNA-101 play a critical role in Cervical Cancer in Uygur Women by targeting COX-2, and might be biomarker for early diagnosis (Lin et al, 2014). MicroRNA-146a has been confirmed to target COX-2, and regulate the complex network of the downstream signal transduction.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-146a Enhances Helicobacter pylori Induced Cell Apoptosis in Human Gastric Cancer Epithelial Cells

Liu²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Helicobacter pylori (H. pylori) infection induces apoptosis in gastric epithelial cells, and this occurrence may link to gastric carcinogenesis. However, the regulatory mechanism of H. pylori-induced apoptosis is not clear. MicroRNA-146a has been implicated as a key regulator of the immune system. This report describes our discovery of molecular mechanisms of microRNA-146a regulation of apoptosis in human gastric cancer cells. We found that overexpression of microRNA-146a by transfecting microRNA-146a mimics could significantly enhance apoptosis, and this up-regulation was triggered by COX-2 inhibition. Furthermore, we found that microRNA-146a density was positively correlated with apoptosis rates in H. pylori-positive gastric cancer tissues and intratumoral microRNA-146a density was negatively correlated with lymph node metastasis among H. pylori-positive gastric cancer patients. Understanding the important roles of microRNA-146a in regulating cell apoptosis in H. pylori infected human gastric cancer cells will contribute to the development of microRNA targeted therapy in the future.

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Roles of MiR-101 and its Target Gene Cox-2 in Early Diagnosis of Cervical Cancer in Uygur Women

Cited by 23 publications

References 17 publications

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

MicroRNAs: Biogenesis, Roles for Carcinogenesis and as Potential Biomarkers for Cancer Diagnosis and Prognosis

Cervical Cancer Gene Therapy by Gene Loaded PEG-PLA Nanomedicine

MicroRNA-146a Enhances Helicobacter pylori Induced Cell Apoptosis in Human Gastric Cancer Epithelial Cells

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