Roles of Sialyl Glycans in HCoV-OC43, HCoV-HKU1, MERS-CoV and SARS-CoV-2 Infections

Sriwilaijaroen, Nongluk; Suzuki, Yasuo

doi:10.1007/978-1-0716-2635-1_17

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2023

2024

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Cited by 3 publications

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“…However, ACE2 is expressed only at low levels in the brain. SARS-CoV-2 can also bind to cell surface sialic acid glycoproteins and gangliosides, including neurons, which are highly expressed on the surface of all cell types targeted by SARS-CoV-2 [ 11 , 12 ]. These results suggest that sialic acid levels play an important role in SARS-CoV-2 cell entry.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicle-Based SARS-CoV-2 Vaccine

Matsuzaka

Yashiro

2023

Vaccines

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Messenger ribonucleic acid (RNA) vaccines are mainly used as SARS-CoV-2 vaccines. Despite several issues concerning storage, stability, effective period, and side effects, viral vector vaccines are widely used for the prevention and treatment of various diseases. Recently, viral vector-encapsulated extracellular vesicles (EVs) have been suggested as useful tools, owing to their safety and ability to escape from neutral antibodies. Herein, we summarize the possible cellular mechanisms underlying EV-based SARS-CoV-2 vaccines.

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Section: Introductionmentioning

confidence: 99%