Roles of singlet oxygen and dissolved organic matter in self-sensitized photo-oxidation of antibiotic norfloxacin under sunlight irradiation

Niu, Xi-Zhi; Busetti, Francesco; Langsa, Markus Heryanto; Croué, Jean-Philippe

doi:10.1016/j.watres.2016.10.002

Cited by 124 publications

(46 citation statements)

References 50 publications

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“…By the control experiment it was observed that no significant mineralization was achieved in dark (supplementary content, Figure S4) and this found is in agreement with the literature [37].…”

Section: Table 1 33 Treatment Efficiency Evaluationsupporting

confidence: 92%

Antibiotics mineralization by electrochemical and UV-based hybrid processes: evaluation of the synergistic effect

Silva

Heberle

Santos

et al. 2018

Environmental Technology

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Antibiotics are not efficiently removed in conventional wastewater treatments. In fact, different advanced oxidation process (AOPs), including ozone, peroxide, UV radiation, among others, are being investigated in the elimination of microcontaminants. Most of AOPs proved to be efficient on the degradation of antibiotics, but the mineralization is on the one hand not evaluated or on the other hand not high. At this work, the UV-based hybrid process, namely Photo-assisted electrochemical oxidation (PEO), was applied, aiming the mineralization of microcontaminants such as the antibiotics Amoxicillin (AMX), Norfloxacin (NOR) and Azithromycin (AZI). The influence of the individual contributions of electrochemical oxidation (EO) and the UV-base processes on the hybrid process (PEO) was analysed. Results showed that AMX and NOR presented higher mineralization rate under direct photolysis than AZI due to the high absorption of UV radiation. For the EO processes, a low mineralization was found for all antibiotics, what was associated to a mass-transport limitation related to the low concentration of contaminants (200 µg/L). Besides that, an increase in mineralization was found, when heterogeneous photocatalysis and EO are compared, due to the influence of UV radiation, which overcomes the mass-transport limitations. Although the UV-based processes control the reaction pathway that leads to mineralization, the best results to mineralize the antibiotics were achieved by PEO hybrid process. This can be explained by the synergistic effect of the processes that constitute them. A higher mineralization was achieved, which is an important and useful finding to avoid the discharge of microcontaminants in the environment.

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Section: Table 1 33 Treatment Efficiency Evaluationsupporting

confidence: 92%

Antibiotics mineralization by electrochemical and UV-based hybrid processes: evaluation of the synergistic effect

Silva

Heberle

Santos

et al. 2018

Environmental Technology

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“…(Ge et al, 2010) (Wei et al, 2013. When further photodegraded, the FQs and their intermediates may suffer from piperazinyl reactions (Yan and Song, 2014) (Wei et al, 2013) (Niu et al, 2016. It is noteworthy that the piperazinyl reactions have been reported in some advanced oxidation processes (AOP) of FQs (Dodd et al, 2005;Martin et al, 2015;Michael et al, 2013;Paul et al, 2007;Zhang and Huang, 2005).…”

Section: Pathways For Apparent Photolysis and Aqueous Hydroxyl-radicamentioning

confidence: 99%

“…The environmental photochemical transformation of individual FQs is now reported in the literature (Ge et al, 2010;Ge et al, 2015;Porras et al, 2016;Sturini et al, 2010;Wei et al, 2013). For example, FQs, such as ciprofloxacin (Ge et al, 2010), danofloxacin (Sturini et al, 2012), norfloxacin (Niu et al, 2016), marbofloxacin and enrofloxacin (Sturini et al, 2010), have been found to follow apparent first-order photodegradation kinetics. Although dissociation of FQs was not fully considered, these previous studies laid a solid foundation for further insight into the phototransformation kinetics.…”

Section: Introductionmentioning

confidence: 98%

Exploring the aquatic photodegradation of two ionisable fluoroquinolone antibiotics – Gatifloxacin and balofloxacin: Degradation kinetics, photobyproducts and risk to the aquatic environment

Halsall

Chen

et al. 2018

Science of The Total Environment

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Fluoroquinolone antibiotics (FQs) are ubiquitous and ionisable in surface waters. Here we investigate gatifloxacin (GAT) and balofloxacin (BAL), two widely used FQs, and determine the photochemical reactivity of their respective dissociation species that arise at different pH to understand the relevance and pathways of phototransformation reactions. Simulated-sunlight experiments and matrix calculations showed that neutral forms (HFQs) of the two antibiotics had the highest apparent photolytic efficiency and hydroxyl-radical oxidation reactivity. Based on the pH-dependent photochemical reactivities, the solar apparent photodegradation half-lives (t) in sunlit surface waters ranged from 14.5-169min and was 1-2 orders of magnitude faster than hydroxyl-radical induced oxidation (t=20.9-29.8h). The corresponding pathways were proposed based on the identification of key intermediates using HPLC-ESI-MS/MS. The apparent photodegradation induced defluorination, decarboxylation, and piperazinyl oxidation and rearrangement, whereas hydroxyl-radical oxidation caused hydroxylated defluorination and piperazinyl hydroxylation. The photomodified toxicity of GAT and BAL was examined using an Escherichia coli activity assay. E. coli activity was not affected by BAL, but was significantly affected by the photo-modified solutions of GAT, indicating that primary photo-degradates have a comparable or higher antibacterial activity than the parent GAT. In fresh water and seawater this antibacterial activity remained high for up to 24h, even after GAT had undergone significant photodegradation (>1 half-life), indicating the potential impact of this chemical on microbial communities in aquatic systems.

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“…FQs undergo direct photolysis and self-sensitized photooxidation via ROS or by indirect photolysis by hydroxyl radicles [71]. The photo transformation pathways of some antibiotics are still unclear but in addition to hydroxyl radicle oxidation, the photochemical transformation of FQs including ciprofloxacin, danofloxacin, norfloxacin, marbofloxacin, and enrofloxacin, has been reported in the past few years [68,71,152,171,194,214], and interestingly they were found to follow the first order photodegradation kinetics. Photodegradation of these FQs is dependent on factors like acid-base dissociations, the presence of different ionizable groups, and the pH of the surrounding environment.…”

Section: Remediation and Ecological Resiliencementioning

confidence: 99%

Perspectives on the antibiotic contamination, resistance, metabolomics, and systemic remediation

et al. 2021

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Antibiotics have been regarded as the emerging contaminants because of their massive use in humans and veterinary medicines and their persistence in the environment. The global concern of antibiotic contamination to different environmental matrices and the emergence of antibiotic resistance has posed a severe impact on the environment. Different mass-spectrometry-based techniques confirm their presence in the environment. Antibiotics are released into the environment through the wastewater steams and runoff from land application of manure. The microorganisms get exposed to the antibiotics resulting in the development of antimicrobial resistance. Consistent release of the antibiotics, even in trace amount into the soil and water ecosystem, is the major concern because the antibiotics can lead to multi-resistance in bacteria which can cause hazardous effects on agriculture, aquaculture, human, and livestock. A better understanding of the correlation between the antibiotic use and occurrence of antibiotic resistance can help in the development of policies to promote the judicious use of antibiotics. The present review puts a light on the remediation, transportation, uptake, and antibiotic resistance in the environment along with a novel approach of creating a database for systemic remediation, and metabolomics for the cleaner and safer environment.

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Roles of singlet oxygen and dissolved organic matter in self-sensitized photo-oxidation of antibiotic norfloxacin under sunlight irradiation

Cited by 124 publications

References 50 publications

Antibiotics mineralization by electrochemical and UV-based hybrid processes: evaluation of the synergistic effect

Antibiotics mineralization by electrochemical and UV-based hybrid processes: evaluation of the synergistic effect

Exploring the aquatic photodegradation of two ionisable fluoroquinolone antibiotics – Gatifloxacin and balofloxacin: Degradation kinetics, photobyproducts and risk to the aquatic environment

Perspectives on the antibiotic contamination, resistance, metabolomics, and systemic remediation

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