Roles of the cholinergic system and vagal innervation in the regulation of GnRH secretion and ovulation: Experimental evidence

Vieyra-Valdez, Elizabeth; Linares-Culebro, Rosa; Rosas-Gavilán, Gabriela; Ramírez-Hernández, Deyra; Domı́nguez-Casalá, Roberto; Morales‐Ledesma, Leticia

doi:10.1016/j.brainresbull.2020.09.009

Cited by 10 publications

(5 citation statements)

References 90 publications

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“…Syncope is commonly observed with high prevalence in the female population, and hypertension is a risk factor in the adult population [57]. The gender effect of syncope can be explained by the effects of vagal innervation on the regulation of GnRH secretion and ovulation [58].…”

Section: Discussionmentioning

confidence: 99%

The Community Pharmacy as a Study Center for the Epidemiological Analysis of the Population Vaccination against SARS-CoV-2: Evaluation of Vaccine Safety and Pharmaceutical Service

Dibenedetto,

Cetrone,

Antonacci

et al. 2024

Pharmacy

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We conducted a monocentric observational study aimed at evaluating the vaccine safety and the pharmaceutical service provided at a community pharmacy (C.PHARM) in the Puglia Region in the period from 29 December 2021 to 12 March 2022 using data from 550 patients of various ages and sexes and with concomitant diseases. We collected anamnestic data, the number of hospitalizations, and any post-vaccination adverse reactions. Interviews using the integrated EQ5 method were also performed to evaluate the quality of the service offered and any therapy preference. As expected, the vaccines were reactogenic after the first dose in the patients with mild–moderate reactions, with younger age and female gender as risk factors. Immune-allergic reactions of a moderate–severe degree were observed in adult females. In the elderly, the vaccination was well tolerated. Comirnaty® showed a favorable O.R. < 1 vs. other vaccines. No cardiovascular events or hospitalizations were observed up to May 2023. Regional data indicate that all treatments during May 2023 were correlated with the viremia. PaxlovidTM was prescribed in 3% of the patients in our center and in 1.46% in the region, and distributed/dispensed on behalf of third parties in accordance with a novel distribution/dispensation protocol of the C.PHARM that resulted in a safe vaccination center providing appropriate patient inclusion during vaccination.

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Section: Discussionmentioning

confidence: 99%

The Community Pharmacy as a Study Center for the Epidemiological Analysis of the Population Vaccination against SARS-CoV-2: Evaluation of Vaccine Safety and Pharmaceutical Service

Dibenedetto,

Cetrone,

Antonacci

et al. 2024

Pharmacy

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“…A rise in LH/FSH ratio is more often due to the development of LH levels rather than a decline in the levels of FSH [ 44 ]. In addition, GnRH also affects the secretion of FSH, which stimulates follicular growth and E2 synthesis [ 45 ]. The increased frequency of GnRH stimulation favors LH production to the detriment of FSH [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Irpex lacteus polysaccharide exhibits therapeutic potential for ovarian fibrosis in PCOS rats via the TGF-β1/smad pathway

Zhou

Chong

et al. 2023

Heliyon

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“…[37][38][39] Moreover, the constructed interactome includes genes/ gene products associated to thermoregulation, such as AVP, 52 IL-1, IL-6, TNF [53][54][55] and leptin, [56][57][58] and enhances the need for future research on sympathetic and vagal innervation and their involvement in the development and persistence of the syndrome. 59 Of note, our work is limited to the investigation of wild-type genes.…”

Section: Infertility and Pcos Interactomementioning

confidence: 99%

Polycystic οvary syndrome revisited: An interactions network approach

Geronikolou

Pavlopoulou

Cokkinos

et al. 2021

Eur J Clin Investigation

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The polycystic ovary syndrome (PCOS) has genetic, epigenetic, metabolic and reproductive aspects. [1][2][3] The World Health Organization reported an overall prevalence of 3.4% (almost 116 million in 2012) among women worldwide. 4 Yet, the actual prevalence ranges from 2% to 20%, depending on the diagnostic criteria employed, the ethnicity and the screening method used to identify ovulatory and/or androgen dysfunction. The clinical manifestations include ovarian physiology and morphology features, high androgen levels and/or oligo-anovulation.The diagnostic criteria vary depending upon three definitions:• the National Institutes of Health-NIH (1990): oligoanovulation, androgen excess, exclusion of other disorders characterized by menstrual irregularity and hyperandrogenaemia. 5 • the Rotterdam consensus-Rott (2003): oligo/unovulation, excess androgen activity, polycystic ovaries by ultrasound. 6-8 • the Androgen Excess PCOS Society-AES (2006): oligo/ un-ovulation, polycystic ovaries by ultrasound, excess

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Roles of the cholinergic system and vagal innervation in the regulation of GnRH secretion and ovulation: Experimental evidence

Cited by 10 publications

References 90 publications

The Community Pharmacy as a Study Center for the Epidemiological Analysis of the Population Vaccination against SARS-CoV-2: Evaluation of Vaccine Safety and Pharmaceutical Service

The Community Pharmacy as a Study Center for the Epidemiological Analysis of the Population Vaccination against SARS-CoV-2: Evaluation of Vaccine Safety and Pharmaceutical Service

Irpex lacteus polysaccharide exhibits therapeutic potential for ovarian fibrosis in PCOS rats via the TGF-β1/smad pathway

Polycystic οvary syndrome revisited: An interactions network approach

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