Roll compaction process modeling: Transfer between equipment and impact of process parameters

Souihi, Nabil; Reynolds, Gavin K.; Tajarobi, Pirjo; Wikström, Håkan; Haeffler, Gunnar; Josefson, Mats; Trygg, Johan

doi:10.1016/j.ijpharm.2015.02.042

Cited by 40 publications

(16 citation statements)

References 24 publications

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“…Numerous experimental studies were conducted in order to evaluate the density distribution of roll compacted ribbons using destructive and non-destructive methods. The studies were conducted on pharmaceutical powders using laboratory roll compactors integrated with fixed side seals (cheek plates), evaluating the density distribution by ultrasonic [3], micro-indentation [4], X-ray tomography [3,4], near infrared chemical imaging [5,6] and pressure gauges [7,8]. Results showed non-uniformity along the ribbon's width with lower densification at the edges and higher at the middle of the produced ribbon.…”

Section: Introductionmentioning

confidence: 99%

Effect of roll compactor sealing system designs: A finite element analysis

et al. 2016

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In the pharmaceutical industry, the roll compaction is part of the dry granulation process, densifying fine powders into ribbons that will be later milled to produce granules with good flowability for subsequent die compaction process. Roll compactors are constructed with a sealing system, limiting the loss of powder from the sides. However, the sealing system may result in unwanted non-uniformity of the ribbon's properties. In this work, a 3D Finite Elements Method (FEM) modeling is used to analyze the roll compaction process and the effect of sealing system designs on the compacted ribbon's density distribution. A density dependent Drucker-Prager Cap (DPC) constitutive model for microcrystalline cellulose (Avicel PH-101) was calibrated and implemented in Abaqus/Explicit. Two different FEM models were investigated, one with a fixed side sealing called cheek plates and another where the side sealing is integrated with the bottom roll called rimmed-roll. Both numerical and experimental results clearly show the non-uniform roll pressure and density distribution for the cheek plates assembly, whereas the rimmed-roll shows an overall more uniformly distributed resultant pressure and density distribution. These results demonstrate the capability of FEM modeling to provide insight and help achieving a better understanding of the roll compaction process.

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Section: Introductionmentioning

confidence: 99%

Effect of roll compactor sealing system designs: A finite element analysis

et al. 2016

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“…The patterned ribbons have a flat side while in the other side have a pattern consisting of half cylinders with a radius of 0.35 mm that intersect at 60° and 120°. This shape is created during the roll compaction process to increase the friction coefficient between the powder and the roll [2].…”

Section: Resultsmentioning

confidence: 99%

Non-destructive density measurements of pharmaceutical products by THz imaging

Garcia-Wernersson

Rodilla

Diaz-Bolado

et al. 2016

2016 41st International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

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In this paper, measurements with a THz imaging system at 346 GHz together with electromagnetic simulations have demonstrated the capability of THz sensing for the non-destructive density determination of intermediate products in the pharmaceutical industry. The results confirm the ability of THz imaging to detect density changes in pharmaceutical samples by measuring the phase variation of the wave transmitted through the sample.

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“…Equation 3.1 and Equation 3.2 were used to determine the pressures gradients experienced by the materials in the nip (no-slip) and slip regions during roller compactions (Johanson, 1965, Reynolds et al, 2010. The equations were solved to determine the nip angle (α) where the boundary condition between the material and the rolls changes from a slip condition to a nip condition (see Figure 3.4) (Reynolds et al, 2010, Souihi et al, 2015. By using Equation 3.3 and Equation 3.4, the δE and ϕw values for each material were used to determine parameters A and υ.…”

Section: Johanson Modelmentioning

confidence: 99%

The effect of roller compaction and tableting stresses on pharmaceutical tablet performance

et al. 2019

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For tablets made by roller compaction the relationships between formulation composition, manufacturing conditions and in-vitro performance were examined. Two filler materials with different characteristics were studied. During tablet production, two main stresses are experienced by a material. The first stress occurs during granulation and the second stress during tableting. These stresses were investigated in terms of the tablet properties and disintegration behaviour. Roller compaction granulation, a continuous dry granulation process, was used to produce granules. The granules were then compacted using varying tableting stresses. The tablets were characterised by their porosity and tensile strength (i.e. compactibility), and were also examined using X-ray to determine the internal tablet structure. The tablet internal structure indicated that the final tablet compactibility was dependent on the RC stress used, which governs the consequent granular properties. The granular material is then affected by the tableting stress used Publications Journal papers:  The effect of roller compaction and tableting stresses on pharmaceutical tablet performance, A

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Roll compaction process modeling: Transfer between equipment and impact of process parameters

Cited by 40 publications

References 24 publications

Effect of roll compactor sealing system designs: A finite element analysis

Effect of roll compactor sealing system designs: A finite element analysis

Non-destructive density measurements of pharmaceutical products by THz imaging

The effect of roller compaction and tableting stresses on pharmaceutical tablet performance

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