During the ascent phase of a missile, a challenging problem occurs that blocks the construction of a high-precision attitude control scheme, which directly affects accurate modeling including disturbances: non-linearities of an actuator, rapidly time-varying parameters, un-modeled dynamics, etc. In order to improve the control performance, an active disturbance rejection control (ADRC) scheme, considering non-linear dynamics of the actuator and wind disturbance during the ascent phase, is proposed in this paper. An expand state observer (ESO) is planned to estimate and compensate the actuator’s non-linear dynamics, flight model uncertainties, and wind disturbance. Therefore, the complex non-linear time-varying control problem is simplified into a linear time-invariant control problem. The pitch attitude control system is controlled by the cascade method and ADRC controllers are designed for actuator close loop and attitude control loop, respectively. The simulation results show that ADRC has strong robustness under different dead-zones and external disturbances of the actuator. On the other hand, ADRC can effectively suppress the external atmospheric disturbance. Compared with the traditional gain-scheduling control scheme, the ADRC scheme can significantly reduce the overloading of the system and shows remarkable performance for tracking as well as wind resistance.