Romantic Surfaces: A Systematic Overview of Stable, Biospecific, and Antifouling Zwitterionic Surfaces

Baggerman, Jacob; Smulders, Maarten M. J.; Zuilhof, Han

doi:10.1021/acs.langmuir.8b03360

Cited by 107 publications

(135 citation statements)

References 87 publications

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“…A good bioactive antifouling layer balances two objectives, namely, maximizing immobilization of bioreceptors and minimizing the nonspecific adsorption of proteins . However, a significant amount of immobilized bioreceptors itself increases the nonspecific adsorption of proteins, due to fouling nature of bioreceptors on their own, as well as due to the changes in antifouling brush structure .…”

Section: Introductionmentioning

confidence: 99%

Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Kuzmyn

Nguyen

Zuilhof

et al. 2019

Adv Materials Inter

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Hierarchical bioactive surfaces are created by visible‐light‐induced surface‐initiated living radical polymerization employing tris[2‐phenylpyridinato‐C2,N]iridium(III) as a photocatalyst. The hierarchical antifouling diblock copolymer structures consist of N‐(2‐hydroxypropyl)‐methacrylamide (first block) and carboxybetaine methacrylate (second block). The living nature of the polymerization is shown by a linear increase in layer thickness (as measured by atomic force microscopy) and reinitiation of the polymerization to create a patterned second block of polymer. The chemical structure of the brushes is confirmed by X‐ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy measurements. The block copolymer brushes demonstrate excellent antifouling properties when exposed to single‐protein solutions or to bovine serum. The second carboxybetaine block of the hierarchical antifouling structures can effectively be biofunctionalized with an anti‐fibrinogen antibody. The coated surfaces show a high affinity and specificity to fibrinogen, while preventing nonspecific adsorption from other proteins in bovine serum.

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Section: Introductionmentioning

confidence: 99%

Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Kuzmyn

Nguyen

Zuilhof

et al. 2019

Adv Materials Inter

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“…Therefore, grafting hydrogels as coatings on various substrates can provide required characteristics and maintain the supporting strength of substrates. Among these hydrogels, zwitterionic polymers or polyampholytes [19,22,24], show good antifouling properties due to charge balance and strong hydration of the ionized groups [25]. As a consequence, the lack of early electrostatic attraction between surfaces and proteins will lead to lower adsorption in the end.…”

Section: Chapter 2 Antifouling Polymer Coatingsmentioning

confidence: 99%

“…Zwitterionic materials have an important role in antifouling applications for their high fouling resistance [19] and long-term stability [22,24]. The growing interest in zwitterionic materials for antifouling purposes [60,61] has stimulated work both on zwitterionic SAMs [62,63] and polymers [64].…”

Section: Zwitterionic and Charge-balanced Ampholytic Polymersmentioning

confidence: 99%

“…Similar to zwitterionic materials [22,23], the polyampholytic hydrogels studied here, have both positive and negative charges. These systems have excellent resistance to fouling and attachment of biomolecules at charge balance condition, where the net charge is zero [24,25]. When exposed to different chemical environments, for instance, bulk pH variations, their surface charge and swelling show response to the pH changes, which indicates that a manipulation of such coatings for surface interaction related functions is possible.…”

Section: Introductionmentioning

confidence: 99%

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Surface characterization and manipulation of polyampholytic hydrogel coatings

Tai

2019

Linköping Studies in Science and Technology. Dissertations

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This thesis is dedicated to building up fundamental knowledge about polyampholytic hydrogels, which are developed in our group for anti-fouling purposes. Charge-balanced polymers, where positive and negative charges balance each other, have emerged as interesting candidates for many applications in materials science. We have prepared charge-balanced materials by forming thickness gradients of oppositely charged polyelectrolytes, and use these as model systems for a systematic investigation of the materials and their responses to environmental changes. These hydrogel gradients were sequentially grafted from substrates via surface-initiated photografting and photopolymerization (SIPGP) of cationic and anionic polyelectrolytes. At some thickness ratios, these form a charge-balanced system where the net surface charge is zero, and with certain similarity to zwitterionic systems. The surface charge of the hydrogels is the principal parameter regulating non-specific protein adsorption, and among other things, we demonstrate that the position of the fouling-resistant charge-neutral region can be manipulated upon pH changes. The chemical compositions of the hydrogel gradients were characterized by microscopic infrared spectroscopy. Optical analysis by spectroscopic ellipsometry and imaging surface plasmon resonance were used to monitor the swelling of the hydrogel films, and protein adsorption onto these in real-time. Surface forces, i.e. the interactions with the hydrogels from an intermolecular perspective, which are related mainly to electrostatic and steric forces, were probed by direct force measurement using atomic force microscopy. Force curves were used to determine the surface charge distribution over the hydrogels, and to indicate the correlation between surface charge and protein adsorption. In the later work, hydrogel gradients were patterned as arrayed spots. Their thicknesses and surface roughness provide further information about the polymer structure and provides a basis for relating ellipsometric swelling profiles to thicknesses as obtained by atomic force microscopy. Finally, it is demonstrated how charged hydrogel films can be used as spacers to tune the optimum distance between silver nanoparticles and fluorophores for metal-enhanced fluorescence (MEF). The aim of this work is to understand polyampholytic hydrogels from various perspectives: surface charges and their distribution, the polymer structure, and surface interactions. The knowledge and experience obtained contribute to the general understanding of zwitterionic materials, and to the development of anti-fouling coatings, optical sensing platforms and other applications of charge-balanced hydrogels.

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“…Among them, zwitterionic polymers are attractive materials for superhydrophilic coatings [ 11 , 12 ]. Polysulfobetaine is a type of zwitterionic polymer.…”

Section: Introductionmentioning

confidence: 99%

Superhydrophilic Coating with Antibacterial and Oil-Repellent Properties via NaIO4-Triggered Polydopamine/Sulfobetaine Methacrylate Polymerization

et al. 2020

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Superhydrophilic coatings have been widely used for the surface modification of membranes or biomedical devices owing to their excellent antifouling properties. However, simplifying the modification processes of such materials remains challenging. In this study, we developed a simple and rapid one-step co-deposition process using an oxidant trigger to fabricate superhydrophilic surfaces based on dopamine chemistry with sulfobetaine methacrylate (SBMA). We studied the effect of different oxidants and SBMA concentrations on surface modification in detail using UV–VIS spectrophotometry, dynamic light scattering, atomic force microscopy, X-ray photoelectron spectroscopy, and surface plasmon resonance. We found that NaIO4 could trigger the rate of polymerization and the optimum ratio of dopamine to SBMA is 1:25 by weight. This makes the surface superhydrophilic (water contact angle < 10°) and antifouling. The superhydrophilic coating, when introduced to polyester membranes, showed great potential for oil/water separation. Our study provides a complete description of the simple and fast preparation of superhydrophilic coatings for surface modification based on mussel-inspired chemistry.

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Romantic Surfaces: A Systematic Overview of Stable, Biospecific, and Antifouling Zwitterionic Surfaces

Cited by 107 publications

References 87 publications

Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Bioactive Antifouling Surfaces by Visible‐Light‐Triggered Polymerization

Surface characterization and manipulation of polyampholytic hydrogel coatings

Superhydrophilic Coating with Antibacterial and Oil-Repellent Properties via NaIO4-Triggered Polydopamine/Sulfobetaine Methacrylate Polymerization

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