To cite this version:Julien Cardin, Dominique Leduc. Determination of refractive index, thickness, and the optical losses of thin films from prism-film coupling measurements. Applied optics, Optical Society of America, 2008, 47 (7) We present a method of analysis of prism-film coupler spectroscopy based on the use of transfer matrix and genetic algorithm, which allows the simultaneous determination of refractive index, thickness, and optical losses of the measured layer.