Room-temperature-operated organic-based acetone gas sensor for breath analysis

Chuang, Ming Yen; Lin, Yu Ting; Tung, Ting Wei; Chang, Liang Yu; Zan, Hsiao Wen; Meng, Hsin Fei; Lu, Chia Jung; Tao, Yu‐Tai

doi:10.1016/j.snb.2017.12.168

Cited by 73 publications

(27 citation statements)

References 51 publications

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“…Hence, this sensor can be used to detect the presence of type-2 diabetic mellitus and type-1 diabetes, respectively. 5,6 Since the developed sensor showed enhanced acetone sensing characteristics at room temperature, the sensing performance of the developed sensor was compared with the sensing performance of commercially purchased Co 3 O 4 nanoparticles (ESI (S1) †). Better sensing response of the Co 3 O 4 thin lm than the commercially purchased Co 3 O 4 nanoparticles revealed the signicant role of microstructural properties, 22,57-62 morphology 63-69 and synthesis methods [70][71][72][73] in deciding the overall sensing performance.…”

Section: View Article Onlinementioning

confidence: 99%

“…Since acetone acts as a fat metabolic nature, the concentration dependence on the exhaled breath is correlated to the fat loss. 5 If the patient's exhaled breath contains more than 1.71 ppm of acetone, it indicates the presence of type-2 diabetic mellitus. 5 On the other hand, the threshold level of exhaled acetone indicating type-1 diabetes is 2.19 ppm.…”

Section: Introductionmentioning

confidence: 99%

“…5 If the patient's exhaled breath contains more than 1.71 ppm of acetone, it indicates the presence of type-2 diabetic mellitus. 5 On the other hand, the threshold level of exhaled acetone indicating type-1 diabetes is 2.19 ppm. 6 DKA is one of the lethal diseases among the different age groups having type-1 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

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Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

et al. 2019

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Section: View Article Onlinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

et al. 2019

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“…[ 21 ] Moreover, as acetone possess fat metabolic nature its concentration dependence on the exhaled breath can also be correlated to the fat loss. [ 22 ] If the exhaled breath analysis shows the presence of more than 1.71 ppm of acetone, then the patient is suffering from type‐2 diabetic mellitus, while 2.19 ppm of acetone in exhaled breath is the indication of type‐1 diabetes. [ 22,23 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 22 ] If the exhaled breath analysis shows the presence of more than 1.71 ppm of acetone, then the patient is suffering from type‐2 diabetic mellitus, while 2.19 ppm of acetone in exhaled breath is the indication of type‐1 diabetes. [ 22,23 ]…”

Section: Introductionmentioning

confidence: 99%

SAM Functionalized ZnO Nanowires for Selective Acetone Detection: Optimized Surface Specific Interaction Using APTMS and GLYMO Monolayers

Singh

Kaur

Drera

et al. 2020

Adv Funct Materials

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In modern days, self‐assembled monolayer (SAM) functionalized surfaces represent an interesting tool for the development of ultrasensitive and selective sensing platforms for the detection of chemical substances such as biomolecules and gases. The ability of SAM to generate different functional groups on a single surface such as zinc oxide (ZnO) can be used to immobilize biomolecules and detect different analytes such as gases, proteins, etc. Herein, SAM functionalized ZnO NW‐based sensors are developed for acetone exhaled breath analysis. ZnO NWs are synthesized using a vapor–liquid–solid mechanism and their functionalization is done with two different SAMs, i.e., (3‐aminopropyl)trimethoxysilane (APTMS) and 3‐glycidoxypropyltrimethoxysilane (GLYMO). The enhancement in the electron depletion layer resistance (and also width) due to the capturing of electrons from the ZnO NWs surface by APTMS and GLYMO molecules is found to be the major reason in their superior sensing performances. The amine (–NH2) groups of APTMS monolayer enhance the sensors selectivity toward acetone due to their reactions with acetone molecules, which produce imine in addition to water molecules. Moreover, after the functionalization with APTMS SAMs, the detection limits of the sensors are improved from 6 to 0.5 ppm, which makes these devices potential candidates for acetone exhaled breath analysis.

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Prospects and Challenges of MXenes as Emerging Sensing Materials for Flexible and Wearable Breath‐Based Biomarker Diagnosis

Hermawan

Amrillah

Riapanitra

et al. 2021

Adv Healthcare Materials

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A fully integrated, flexible, and functional sensing device for exhaled breath analysis drastically transforms conventional medical diagnosis to non-invasive, low-cost, real-time, and personalized health care. 2D materials based on MXenes offer multiple advantages for accurately detecting various breath biomarkers compared to conventional semiconducting oxides. High surface sensitivity, large surface-to-weight ratio, room temperature detection, and easy-to-assemble structures are vital parameters for such sensing devices in which MXenes have demonstrated all these properties both experimentally and theoretically. So far, MXenes-based flexible sensor is successfully fabricated at a lab-scale and is predicted to be translated into clinical practice within the next few years. This review presents a potential application of MXenes as emerging materials for flexible and wearable sensor devices. The biomarkers from exhaled breath are described first, with emphasis on metabolic processes and diseases indicated by abnormal biomarkers. Then, biomarkers sensing performances provided by MXenes families and the enhancement strategies are discussed. The method of fabrications toward MXenes integration into various flexible substrates is summarized. Finally, the fundamental challenges and prospects, including portable integration with Internet-of-Thing (IoT) and Artificial Intelligence (AI), are addressed to realize marketization.

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Room-temperature-operated organic-based acetone gas sensor for breath analysis

Cited by 73 publications

References 51 publications

Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

SAM Functionalized ZnO Nanowires for Selective Acetone Detection: Optimized Surface Specific Interaction Using APTMS and GLYMO Monolayers

Prospects and Challenges of MXenes as Emerging Sensing Materials for Flexible and Wearable Breath‐Based Biomarker Diagnosis

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Room-temperature-operated organic-based acetone gas sensor for breath analysis

Cited by 73 publications

References 51 publications

Development of an acetone sensor using nanostructured Co3O4 thin films for exhaled breath analysis

Development of an acetone sensor using nanostructured Co3O4 thin films for exhaled breath analysis

SAM Functionalized ZnO Nanowires for Selective Acetone Detection: Optimized Surface Specific Interaction Using APTMS and GLYMO Monolayers

Prospects and Challenges of MXenes as Emerging Sensing Materials for Flexible and Wearable Breath‐Based Biomarker Diagnosis

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Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis

Development of an acetone sensor using nanostructured Co₃O₄ thin films for exhaled breath analysis