Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14

Abstract

Roquefornine A, a sesterterpenoid with an unprecedented 5/6/5/5/6-membered pentacyclic system, was characterized from Penicillium roqueforti YJ-14.

Discovery of two ent-atisane diterpenoid lactones with AChE inhibitory activity from the roots of Euphorbia fischeriana

“…Finally, the absolute configuration of C-3 in 2 was assigned using the induced ECD data of the Rh 2 (OCOCF 3 ) 4 complex (Snatzke's method). 30,31 Based on the empirical bulkiness rule related to chiral secondary alcohols, the negative Cotton effect at 350 nm of the complex in this experiment, on the basis of the inherent contribution being subtracted, indicated a 3 R -configuration (Fig. 5), and the ECD calculation also revealed the same conclusion (Fig.…”

Bipoladien A, a Sesterterpenoid Containing an Undescribed 5/8/5/7 Carbon Skeleton from Bipolaris maydis

“…Sesterterpenoids, consisting of five isoprene building blocks, are widely distributed in marine organisms, terrestrial fungi, higher plants, insects, etc. − Compared with other terpenoids, sesterterpenoids only occupy a small part of the enormous family . In recent years, a variety of sesterterpenoids with intriguing skeletons have been discovered, such as norcolquhounoid A and aspterpenacid A. , Moreover, many sesterterpenoids exhibit good bioactivities, such as asperterpenoid A showed inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B and 14- epi -colquhounoid D exhibited immunosuppressive activity, etc. , Our group is also committed to discovering sesterterpenoids with novel structures from fungal sources, such as niduterpenoids A and B, and bipolarolides A–G, etc. , …”

Penaloidines A and B: two unprecedented pyridine alkaloids from Penicillium sp. KYJ-6

“…In our previous work, we reported several sesterterpenoids and isoprenoid epoxycyclohexenones with a new skeleton from Penicillium sp., which was separated from Aconitum vilmorinianum Kom. [16][17][18] It is part of our work to continue searching for structurally intriguing and biologically active natural products from Penicillium fungi. In addition, Illigera, a small vine belonging to the Hernandiaceae family, was also a previous research topic of our group.…”