Roquin Paralogs Add a New Dimension to ICOS Regulation

Bertino, Sarah A.; Craft, Joe

doi:10.1016/j.immuni.2013.03.007

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Roquins in vertebrate humans, invertebrate flies and nematodes exhibit similar subcellular localization: they localize mainly in P-bodies in the cytoplasm, concentrate in stress granules in response to stress, function as RNA-binding proteins, and trigger mRNA decay [ 16 ]. In mice, both Roquin-1 and Roquin-2 can bind nucleic acids and demonstrate functional redundancy [ 35 , 36 ]. Roquins and Regnases can cooperate or act independently to regulate mRNA silencing post-transcriptionally [ 19 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System

Li,

Yang,

Zhang

et al. 2024

IJMS

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The Roquin family is a recognized RNA-binding protein family that plays vital roles in regulating the expression of pro-inflammatory target gene mRNA during the immune process in mammals. However, the evolutionary status of the Roquin family across metazoans remains elusive, and limited studies are found in fish species. In this study, we discovered that the RC3H genes underwent a single round of gene duplication from a primitive ancestor during evolution from invertebrates to vertebrates. Furthermore, there were instances of species-specific gene loss events or teleost lineage-specific gene duplications throughout evolution. Domain/motif organization and selective pressure analysis revealed that Roquins exhibit high homology both within members of the family within the same species and across species. The three rc3h genes in zebrafish displayed similar expression patterns in early embryos and adult tissues, with rc3h1b showing the most prominent expression among them. Additionally, the promoter regions of the zebrafish rc3h genes contained numerous transcription factor binding sites similar to those of mammalian homologs. Moreover, the interaction protein network of Roquin and the potential binding motif in the 3’-UTR of putative target genes analysis both indicated that Roquins have the potential to degrade target mRNA through mechanisms similar to those of mammalian homologs. These findings shed light on the evolutionary history of Roquin among metazoans and hypothesized their role in the immune systems of zebrafish.

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Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System

Li,

Yang,

Zhang

et al. 2024

IJMS

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“…The interactions between T FH cells and B cells could be realized via high expression of chemokine receptor CXCR5 on the surface of T FH and the expression of its ligand CXCL13 in the follicular GC of the B cells, which could result in the migration and location of T FH into the GC [14,15]. Moreover, the expression of costimulatory molecule ICOS on the surface of T FH could further induce the production and function maintenance of T FH cells in participating in the generation of GC and memory B cells via interaction with its ligand ICOS-L. Several studies have shown that downregulation expression of ICOS could result in decreasing number of T FH , thereby affecting the mature and class switching of B cells, suggesting the irreplaceable role of ICOS in T FH function [16][17][18]. Programmed death receptor 1 (PD), which could interact with its ligand PD-L1 to transmit inhibition signaling to affect the T-cell differentiation and Treg production, is another important marker on T FH cells.…”

Section: Discussionmentioning

confidence: 99%

The role of follicular T helper cells in patients with malignant lymphoid disease

Zhou

Zhang

et al. 2017

Hematology

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Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses

Yang

Huang

Wang

et al. 2015

Crit Rev Eukaryot Gene Expr

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Posttranscriptional gene regulation is a rapid and effective way to mediate the expression of inflammatory genes. CCCH-type zinc finger proteins are nucleotide-binding molecules involved in RNA metabolism pathways such as RNA splicing, polyadenylation, and messenger RNA (mRNA) decay. Among these proteins, tristetraproline, Roquins, and Regnase-1/monocyte chemotactic protein-1-induced protein-1 have been recently reported to be responsible for mRNA instability. They bind to mRNAs harboring unique motifs and induce mRNA decay. In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline, Roquins, and Regnase-1. The target mRNAs to be destabilized by those CCCH-type zinc finger proteins also are included. Notably, most target mRNAs encode cytokines and other inflammatory mediators, suggesting the immune regulation role of CCCH zinc finger proteins. Mice carrying a genetic null allele or modification of these genes display severe symptoms of autoimmune diseases. Taken together, data show that CCCH-type zinc finger proteins play a crucial role in regulating immune response by targeting multiple mRNAs, and including decay. Further understanding the functions of these proteins may provide new therapeutic targets for immune-related disorders in the future.

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Roquin Paralogs Add a New Dimension to ICOS Regulation

Cited by 3 publications

References 9 publications

Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System

Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System

The role of follicular T helper cells in patients with malignant lymphoid disease

Emerging Roles of CCCH-Type Zinc Finger Proteins in Destabilizing mRNA Encoding Inflammatory Factors and Regulating Immune Responses

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